Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization.

Abstract:

:Patients with congenital protein S (PS) deficiency show a hereditary predisposition for thrombosis, and PS deficiency is prevalent among Japanese populations. Diagnosis is based on symptoms of thrombosis and reduced PS activity. Three reagents that use different measurement principles for determining PS activity are available in Japan. This study aimed to confirm the possibility of harmonization of these three reagents to establish a universal standard for PS activity in Japanese populations. Commercial normal plasma and plasma samples obtained from healthy individuals and healthy pregnant women were tested at three facilities using three reagents for measuring PS: STA-Staclot Protein S (STA-PS), HemosIL Protein S (Clotting) (IL-PS), and a total PS assay (SNT-PS). The within-run precision of each reagent was good, as each had a coefficient of variation of ≤ 3.8%. The dilution linearity for each reagent was also good. The correlation coefficient was 0.94 for STA-PS vs. IL-PS, 0.93 for SNT-PS vs. STA-PS, and 0.90 for SNT-PS vs. IL-PS, indicating a good correlation. Although the three reagents available in Japan for measuring PS activity use different measurement methods, each showed good performance, and large differences were not observed between the obtained values. Harmonization among them appears possible.

journal_name

Int J Hematol

authors

Ieko M,Hotta T,Watanabe K,Adachi T,Takeuchi S,Naito S,Yoshida M,Ohmura K,Takahashi N,Morishita E,Tsuda H,Kang D

doi

10.1007/s12185-020-03049-8

subject

Has Abstract

pub_date

2021-01-08 00:00:00

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-020-03049-8

pub_type

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