A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement.

Abstract:

:Philadelphia (Ph) chromosome as a result of t (9; 22) (q34; q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients. Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients. CML cases with fusion transcripts such as e13a3 in which ABL exon 3 rather than exon 2 has fused to BCR are very rare. Such reported cases with the e13a3 transcript show the Ph chromosome on karyotype analysis. We reported an atypical karyotype CML patient with the e13a3 BCR-ABL transcript caused by complex translocation. Fluorescence in situ hybridization (FISH) analysis of the metaphase led to a precise cytogenetical characterization. The patient showed favorable response to imatinib, and achieved major molecular responses.

journal_name

Int J Hematol

authors

Masuko M,Furukawa T,Abe T,Wada R,Maruyama S,Kitajima T,Shibasaki Y,Toba K,Okada M,Aizawa Y

doi

10.1007/s12185-009-0368-4

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

230-234

issue

2

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-009-0368-4

journal_volume

90

pub_type

杂志文章
  • Immunodeficient mouse models of lymphoid tumors.

    abstract::Severe combined immunodeficient (SCID) mice lack functional T- and B-cells and readily accept human xenografts, including hematopoietic malignancies. Accordingly, SCID mice have been used to study the growth and behavior of lymphoid tumors in vivo. The SCID mouse models of disease mimic human diseases and have provide...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02982640

    authors: Imada K

    更新日期:2003-05-01 00:00:00

  • Systemic HD-MTX for CNS prophylaxis in high-risk DLBCL patients: a prospectively collected, single-center cohort analysis.

    abstract::We evaluated the efficacy of systemic high-dose methotrexate (HD-MTX) for CNS prophylaxis in a prospectively recruited cohort of DLBCL patients at high risk of CNS relapse. High-risk CNS relapse was defined as the involvement of ≥ 2 extranodal sites with elevated lactate dehydrogenase (LDH); CNS international prognost...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02653-7

    authors: Lee K,Yoon DH,Hong JY,Kim S,Lee K,Kang EH,Huh J,Park CS,Lee SW,Suh C

    更新日期:2019-07-01 00:00:00

  • Molecular nature of antigens implicated in immune neutropenias.

    abstract::Granulocyte (neutrophil) antibodies can cause autoimmune neutropenia, drug-induced neutropenia, immune neutropenia after bone marrow transplantation, neonatal immune neutropenia, refractoriness to granulocyte transfusions as well as febrile and pulmonary transfusion reactions. In the last decade, considerable progress...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF03165292

    authors: Bux J

    更新日期:2002-08-01 00:00:00

  • A case of double-refractory multiple myeloma with both the IgH-MMSET fusion protein and the congenital abnormality t(11;22).

    abstract::A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02603-3

    authors: Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

    更新日期:2019-06-01 00:00:00

  • Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia.

    abstract::Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-019-02798-5

    authors: Harada-Shirado K,Wang X,Mori H,Fukatsu M,Takahashi H,Shichishima-Nakamura A,Kimura S,Ohkawara H,Yamada S,Ito T,Ikezoe T

    更新日期:2020-03-01 00:00:00

  • A prospective randomized trial of KRN8602 and cytosine arabinoside vs. daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. The KRN8602 Leukemia Study Group.

    abstract::A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

    更新日期:1999-07-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1211-x

    authors: Kato M,Koh K,Kikuchi A,Hanada R

    更新日期:2012-12-01 00:00:00

  • Low expression of FCGRIIB in macrophages of immune thrombocytopenia-affected individuals.

    abstract::Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12185-012-1187-6

    authors: Wu Z,Zhou J,Prsoon P,Wei X,Liu X,Peng B

    更新日期:2012-11-01 00:00:00

  • Ras/MAPK syndromes and childhood hemato-oncological diseases.

    abstract::Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-012-1239-y

    authors: Aoki Y,Matsubara Y

    更新日期:2013-01-01 00:00:00

  • Efficacy and safety of switching to nilotinib in patients with CML-CP in major molecular response to imatinib: results of a multicenter phase II trial (NILSw trial).

    abstract::We evaluated the efficacy and safety of switching to nilotinib in CML-CP patients who had achieved MMR with continuous detectable BCR-ABL1 transcript levels after long-term imatinib treatment. Patients who had achieved MMR, but not deep molecular response (DMR), after > 18 months from the initiation of imatinib receiv...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12185-018-2401-y

    authors: Ishikawa J,Matsumura I,Kawaguchi T,Kuroda J,Nakamae H,Miyamoto T,Matsuoka KI,Shibayama H,Hino M,Hirase C,Kamimura T,Shimose T,Akashi K,Kanakura Y

    更新日期:2018-05-01 00:00:00

  • Oxidative stress response and signaling in hematological malignancies and HIV infection.

    abstract::Hematopoietic cells can be exposed to a wide spectrum of oxidative stresses. Excessive oxidative stress damages biomolecules such as DNA, proteins, and lipids, leading to cellular dysfunction and cell death. Accumulation of such damage provokes noxious effects on individuals, resulting in diseases such as hematopoieti...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Masutani H

    更新日期:2000-01-01 00:00:00

  • Predictors of anxiety and depression in Egyptian thalassemic patients: a single center study.

    abstract::Thalassemic patients are vulnerable to emotional and behavioral problems. Each patient age group exhibits problems unique to that stage of development, and although up to 80 % of thalassemic patients are likely to have psychological disorders, e.g., anxiety and depression, predictors of these disorders remain poorly u...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-013-1322-z

    authors: Yahia S,El-Hadidy MA,El-Gilany AH,Anwar R,Darwish A,Mansour AK

    更新日期:2013-05-01 00:00:00

  • Molecular basis of beta-thalassemia minor in Taiwan.

    abstract::The mutations producing beta-thalassemia minor in 227 Taiwanese were studied using the method of naturally and amplified created restriction sites. beta-Thalassemia minor was caused by one beta-globin gene mutation in most of the cases (225/227); only a few cases were caused by two gene mutation (2/227). The most comm...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Chang JG,Lin CP,Liu TC,Chiou SS,Chen PH,Lee LS,Chen TP

    更新日期:1994-06-01 00:00:00

  • DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia.

    abstract::DNA methylation provides a major epigenetic code (besides histone modification) of the lineage- and development-specific genes (such as regulators of differentiation in the hematopoietic lineages) that control expression of normal cells. However, DNA methylation is also involved in malignancies because aberrant methyl...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/ijh97.04094

    authors: Rüter B,Wijermans PW,Lübbert M

    更新日期:2004-08-01 00:00:00

  • Successful mobilization of peripheral blood stem cells with bortezomib + high-dose cyclophosphamide + G-CSF in a light chain myeloma patient after failure with Total Therapy 2.

    abstract::Autologous stem cell transplantation is considered the best post-induction therapy for multiple myeloma (MM). Therefore, therapy for myeloma should be chosen not only on the basis of efficacy, but also taking into account their impact on the hematopoietic stem cell compartment. We describe the case of a MM patient in ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0354-x

    authors: Giglio G,Romito S,Carrozza F,Musacchio M,Antuzzi G,Gigli R,Magri M,Bavaro P,Di Bartolomeo P,Dell'Isola M,Accorsi P

    更新日期:2009-07-01 00:00:00

  • Neuron-specific enolase in hemophagocytic lymphohistiocytosis: a potential indicator for macrophage activation?

    abstract::To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels incre...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Honda K,Ohga S,Takada H,Nomura A,Ohshima K,Kinukawa N,Mizuno Y,Hara T

    更新日期:2000-07-01 00:00:00

  • Imatinib mesylate in the treatment of chronic myelogenous leukemia.

    abstract::Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogeneti...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/ijh97.04054

    authors: Borthakur G,Cortes JE

    更新日期:2004-06-01 00:00:00

  • MALT lymphoma of the thymus with Sjögren's syndrome: biphasic changes in serological abnormalities over a 4-year period following thymectomy.

    abstract::Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0324-3

    authors: Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

    更新日期:2009-06-01 00:00:00

  • Biology of normal and acute myeloid leukemia stem cells.

    abstract::The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse be...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/IJH97.05144

    authors: Dick JE,Lapidot T

    更新日期:2005-12-01 00:00:00

  • Differential expression of HOX genes upon activation of leukocyte sub-populations.

    abstract::The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-008-0057-8

    authors: Morgan R,Whiting K

    更新日期:2008-04-01 00:00:00

  • Serum stem cell factor levels in patients with aplastic anemia.

    abstract::Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Nimer SD,Leung DH,Wolin MJ,Golde DW

    更新日期:1994-10-01 00:00:00

  • Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-012-1244-1

    authors: Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

    更新日期:2013-01-01 00:00:00

  • Establishment of novel cell lines derived from two patients with chronic myelogenous leukemia in blast crisis; IMS-BC1 and IMS-BC2 which exhibit markedly different sensitivity to apoptosis.

    abstract::We established two novel cell lines, designated as IMS-BC1 and IMS-BC2, from two patients with chronic myelogenous leukemia in blast crisis. The two cell lines were positive for CD13 and CD33 and negative for CD34 and HLA-DR by surface marker analysis. IMS-BC1 had four Philadelphia (Ph1) chromosomes and a breakpoint w...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/s0925-5710(98)00007-3

    authors: Nagamura F,Nagamura-Inoue T,Tojo A,Minamihisamatsu M,Tanabe T,Zaike Y,Tani K,Saisho H,Asano S

    更新日期:1998-04-01 00:00:00

  • CD64 surface expression on neutrophils and monocytes is significantly up-regulated after stimulation with granulocyte colony-stimulating factor during CHOP chemotherapy for patients with non-Hodgkin's lymphoma.

    abstract::The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02983535

    authors: Kakinoki Y,Kubota H,Yamamoto Y

    更新日期:2004-01-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

    abstract::Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.A30615

    authors: Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

    更新日期:2007-04-01 00:00:00

  • Pediatric myeloid/NK cell precursor lymphoma/leukemia expressing T/NK immunophenotype markers.

    abstract::Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-010-0504-1

    authors: Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

    更新日期:2010-04-01 00:00:00

  • Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.

    abstract::A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982029

    authors: Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

    更新日期:2002-02-01 00:00:00

  • Unique association of Waldenström macroglobulinemia with optic neuritis and monoclonal T cell expansion.

    abstract::Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-013-1372-2

    authors: Morita K,Yoshimi A,Masuda A,Ichikawa M,Yatomi Y,Kurokawa M

    更新日期:2013-08-01 00:00:00

  • Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: a large retrospective study.

    abstract::Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...

    journal_title:International journal of hematology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s12185-018-2520-5

    authors: Piccin A,Tagnin M,Vecchiato C,Al-Khaffaf A,Beqiri L,Kaiser C,Agreiter I,Negri G,Kob M,Di Pierro A,Vittadello F,Mazzoleni G,Eisendle K,Fontanella F

    更新日期:2018-12-01 00:00:00

  • Hydroxyurea for hemoglobin E/β-thalassemia: a systematic review and meta-analysis.

    abstract::Hemoglobin E-beta thalassemia (Hb E/β-thalassemia) is a distinct, yet common, type of β-thalassemia, in which the patient co-inherits a β-thalassemia allele from one parent, and a structural variant, Hb E, from the other parent. This co-inheritance leads to remarkable clinical heterogeneity, varying degrees of chronic...

    journal_title:International journal of hematology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s12185-017-2307-0

    authors: Algiraigri AH,Kassam A

    更新日期:2017-12-01 00:00:00