当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Eltrombopag therapy in newly diagnosed steroid non-responsive ITP patients.

Eltrombopag therapy in newly diagnosed steroid non-responsive ITP patients.

Abstract：

:Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterised by isolated thrombocytopenia (peripheral blood platelet count <100 × 10(9)/L) in the absence of other causes or disorders that may be associated with thrombocytopenia. The upfront treatment in newly diagnosed ITP patients is steroids; however, about one-third patients do not respond, and require other treatment, including IVIg, anti-D, or splenectomy. Previous studies have shown decreased platelet production in some ITP patients, aside from the evidence of enhanced platelet destruction. Thrombopoietin receptor agonists (TPO-RA), such as eltrombopag have been shown to provide good response in steroid non-responsive chronic ITP patients. We have studied response to eltrombopag in 25 newly diagnosed steroid non-responsive ITP patients; 80 % patients showed response at the end of 1 month, and 76 % sustained response at the end of 3 months. The platelet count rose from a mean value of 17.5 ± 3.6-152.5 ± 107.9 × 10(9)/L at the end of 1 month. Our results suggest a possible role of eltrombopag in newly diagnosed steroid non-responsive ITP patients. However, our study is limited in that it is a single-centre study, with a small sample size, and lacks a long-term safety profile. Our findings highlight the potential value of a larger prospective study on the upfront use of TPO-RA in patients of ITP.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Tripathi AK,Shukla A,Mishra S,Yadav YS,Yadav DK

doi

10.1007/s12185-014-1533-y

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

413-7

issue

4

eissn

0925-5710

issn

1865-3774

journal_volume

99

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Hematopoietic stem cell transplantation for therapy-related myelodysplastic syndrome and acute leukemia: a single-center analysis of 47 patients.

    abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0640-7

    authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

    更新日期：2010-09-01 00:00:00

  • Pathophysiology and treatment of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS).

    abstract：:The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：

    authors： Kakishita E

    更新日期：2000-06-01 00:00:00

  • Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis.

    abstract：:von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are express...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-008-0065-8

    authors： Nakayama T,Matsushita T,Yamamoto K,Mutsuga N,Kojima T,Katsumi A,Nakao N,Sadler JE,Naoe T,Saito H

    更新日期：2008-05-01 00:00:00

  • Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.

    abstract：:Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-015-1814-0

    authors： Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

    更新日期：2015-08-01 00:00:00

  • Polyphosphate: a link between platelets, coagulation and inflammation.

    abstract：:Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothromb...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-012-1054-5

    authors： Morrissey JH

    更新日期：2012-04-01 00:00:00

  • Reduced risk of bacterial infection in multiple myeloma patients with VAD regimen without intermittent high-dose dexamethasone.

    abstract：:Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0735-1

    authors： Isoda A,Matsumoto M,Nakahashi H,Mawatari M,Manaka A,Sawamura M

    更新日期：2011-01-01 00:00:00

  • Molecular basis of clonal evolution in multiple myeloma.

    abstract：:The treatment outcome of multiple myeloma (MM) is worse than expected from the average numbers of non-synonymous mutations, which are roughly correlated with the prognosis of cancer patients. The refractoriness of MM may be ascribed to the complex genomic architecture and clonal behavior of the disease. In MM, disease...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-020-02829-6

    authors： Furukawa Y,Kikuchi J

    更新日期：2020-04-01 00:00:00

  • Establishment of an HS23 stromal cell-dependent myeloma cell line: fibronectin and IL-6 are critical.

    abstract：:A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0698-2

    authors： Sakai A,Oda M,Itagaki M,Yoshida N,Arihiro K,Kimura A

    更新日期：2010-11-01 00:00:00

  • A combined approach using global coagulation assays quickly differentiates coagulation disorders with prolonged aPTT and low levels of FVIII activity.

    abstract：:Patients with mild/moderate hemophilia (H)A, acquired HA (AHA) and lupus anticoagulants (LA), have prolonged aPTTs with low levels of factor (F)VIII activity, but the differentiation of these disorders is complex and time consuming. We established an approach to quickly differentiate these disorders using comprehensiv...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2108-x

    authors： Matsumoto T,Nogami K,Shima M

    更新日期：2017-02-01 00:00:00

  • CD64 surface expression on neutrophils and monocytes is significantly up-regulated after stimulation with granulocyte colony-stimulating factor during CHOP chemotherapy for patients with non-Hodgkin's lymphoma.

    abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983535

    authors： Kakinoki Y,Kubota H,Yamamoto Y

    更新日期：2004-01-01 00:00:00

  • Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma.

    abstract：:The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene is a favorable progno...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.06087

    authors： Hiraga J,Kinoshita T,Ohno T,Mori N,Ohashi H,Fukami S,Noda A,Ichikawa A,Naoe T

    更新日期：2006-10-01 00:00:00

  • Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia.

    abstract：:Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however,...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-017-2368-0

    authors： Furuyama K,Kaneko K

    更新日期：2018-01-01 00:00:00

  • Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses.

    abstract：:In addition to reduced-intensity conditioning, which has expanded the eligibility for hematopoietic cell transplantation (HCT) to older patients, increased availability of alternative donors, including HLA-mismatched unrelated donors, has increased access to allogeneic HCT for more patients. However, acute graft-versu...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-013-1421-x

    authors： Maeda Y

    更新日期：2013-09-01 00:00:00

  • Clonality analysis of granulocytes and T lymphocytes in healthy females by the PCR-based HUMARA method.

    abstract：:Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Nakahara Y,Suzuki H,Ohashi H,Hatano S,Tomita A,Kinoshita T,Murate T,Saito H,Hotta T

    更新日期：1999-06-01 00:00:00

  • Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.

    abstract：:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1555-5

    authors： Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

    更新日期：2014-06-01 00:00:00

  • Molecular analysis of the t(1;19)(q23;p13) translocation observed in adult leukemias.

    abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

    更新日期：1994-12-01 00:00:00

  • Constitutively activated Rho guanosine triphosphatases regulate the growth and morphology of hairy cell leukemia cells.

    abstract：:Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983784

    authors： Zhang X,Machii T,Matsumura I,Ezoe S,Kawasaki A,Tanaka H,Ueda S,Sugahara H,Shibayama H,Mizuki M,Kanakura Y

    更新日期：2003-04-01 00:00:00

  • Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance.

    abstract：:Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02982545

    authors： Ruscetti FW,Bartelmez SH

    更新日期：2001-07-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract：:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02804-w

    authors： Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期：2020-04-01 00:00:00

  • A 13-24 C-terminal peptide related to PF4 accelerates hematopoietic recovery of progenitor cells in vivo in mice treated with 5-fluorouracil.

    abstract：:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of th...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/s0925-5710(97)00065-0

    authors： Aïdoudi S,Lebeurier I,Amiral J,Quentin G,Caen JP,Han ZC

    更新日期：1997-12-01 00:00:00

  • Treatment patterns and clinical outcomes in patients with chronic immune thrombocytopenia (ITP) switched to eltrombopag or romiplostim.

    abstract：:This observational study aimed to assess real-world treatment patterns and clinical outcomes for patients with chronic immune thrombocytopenia (ITP) currently being treated with eltrombopag or romiplostim after switching from corticosteroids, rituximab, or the alternate thrombopoietin receptor agonist (TPO-RA). The st...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1731-7

    authors： Kuter DJ,Macahilig C,Grotzinger KM,Poston SA,Wang PF,Dawson KL,Ward M

    更新日期：2015-03-01 00:00:00

  • Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children.

    abstract：:The distinction between RAEB, RAEB-T and AML M6a is difficult when erythroblasts in the bone marrow (BM) exceed 50%. We analyzed 19 children (2 RAEB, 13 RAEB-T and 4 AML M6a) enrolled in a prospective pathological central review in Japan and divided them into two groups according to the myeloblasts percentage among no...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-008-0183-3

    authors： Honda Y,Manabe A,Tsuchida M,Zaike Y,Masunaga A,Inoue M,Kobayashi R,Ohtsuka Y,Kikuchi A,Nakahata T,From the MDS Committee, the Japanese Society of Pediatric Hematology.

    更新日期：2008-12-01 00:00:00

  • Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.

    abstract：:Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1244-1

    authors： Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

    更新日期：2013-01-01 00:00:00

  • Molecular remission achieved by interferon therapy in a patient with cytogenetically relapsed chronic myelogenous leukemia after syngeneic bone marrow transplantation.

    abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/0925-5710(96)00486-0

    authors： Yano K,Iijima K,Sao H,Kobayashi M

    更新日期：1996-10-01 00:00:00

  • Relative increase in lymphocytes from as early as 1 month predicts improved response to dasatinib in chronic-phase chronic myelogenous leukemia.

    abstract：:Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1483-9

    authors： Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

    更新日期：2014-01-01 00:00:00

  • Clinical and hematological characteristics of uncommon beta-globin variants in Thailand.

    abstract：:Hemoglobin (Hb) E is the commonest beta-globin variant in Thailand. Other uncommon variants have been rarely reported. We performed direct DNA sequencing of the entire beta-globin gene in cases showing unidentified bands by isolectric focusing electrophoresis or high-performance liquid chromatography. Six different be...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0334-1

    authors： Uaprasert N,Rojnuckarin P,Settapiboon R,Amornsiriwat S,Sutcharitchan P

    更新日期：2009-06-01 00:00:00

  • Treatment with cerivastatin in primary mixed hyperlipidemia induces changes in platelet aggregation and coagulation system components.

    abstract：:Platelet activation, impairment of fibrinolysis, activation of the coagulation pathway, and dyslipidemia are important factors in the pathogenesis and progression of ischemic heart disease, and patients generally need to use an antiplatelet agent. Lipid-lowering cerivastatin, a novel 3-hydroxy-3-methylglutaryl coenzym...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02982799

    authors： Ural AU,Yilmaz MI,Avcu F,Yalcin A

    更新日期：2002-10-01 00:00:00

  • CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement.

    abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

    journal_title：International journal of hematology

    pub_type： 信件

    doi：10.1007/s12185-010-0675-9

    authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

    更新日期：2010-10-01 00:00:00

  • Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin.

    abstract：:B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0741-3

    authors： Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

    更新日期：2011-01-01 00:00:00

  • Myelodysplastic syndrome in a patient with a unique constitutional chromosome abnormality t(2;11) (q31;p13).

    abstract：:We present a case of myelodysplastic syndrome (MDS), which developed into an overt leukemic phase in a 15-year-old female with a rare constitutional abnormality [46,XX,t(2;11) (q31;p13)]. The patient entered complete remission after 3 months of chemotherapy. On chromosome analysis during remission, the t(2;11) (q31;p1...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Hinoda Y,Itoh H,Takahashi T,Adachi M,Tsujisaki M,Imai K,Yachi A

    更新日期：1992-08-01 00:00:00