Diffuse follicular lymphoma variant with a typical diagnostic pattern and an unusually aggressive clinical presentation.

abstract：:According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

journal_title：International journal of hematology

authors： Zoi K,Cross NC

更新日期：2015-03-01 00:00:00

abstract：:A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

journal_title：International journal of hematology

authors： Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

更新日期：2010-10-01 00:00:00

abstract：:Acute graft-versus-host disease (aGVHD) is the major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation. To date, there are no consensus specific plasma biomarkers for aGVHD. We recently identified several candidates differentially expressed in aGVHD patients. Here, we have val...

journal_title：International journal of hematology

authors： Ye H,Lv M,Zhao X,Zhao X,Huang X

更新日期：2012-06-01 00:00:00

abstract：:Platelet activation, impairment of fibrinolysis, activation of the coagulation pathway, and dyslipidemia are important factors in the pathogenesis and progression of ischemic heart disease, and patients generally need to use an antiplatelet agent. Lipid-lowering cerivastatin, a novel 3-hydroxy-3-methylglutaryl coenzym...

journal_title：International journal of hematology

authors： Ural AU,Yilmaz MI,Avcu F,Yalcin A

更新日期：2002-10-01 00:00:00

abstract：:Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...

journal_title：International journal of hematology

authors： Chi HS

更新日期：2002-08-01 00:00:00

abstract：:Granulocyte immunofluorescence and granulocyte agglutination tests are standard methods for detecting human neutrophil antigen (HNA) antibodies (Abs); however, these require a typed panel of neutrophils, which can be time-consuming to develop, and it remains difficult to determine antibody specificity in some cases. W...

journal_title：International journal of hematology

authors： Amakishi E,Irie Y,Nishizawa K,Kamada H,Nakajima F,Matsuyama N,Ishii H,Matsukura H,Yasui K,Hirayama F

更新日期：2015-04-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...

journal_title：International journal of hematology

authors： Baldoni S,Sportoletti P,Del Papa B,Aureli P,Dorillo E,Rosati E,Ciurnelli R,Marconi P,Falzetti F,Di Ianni M

更新日期：2013-08-01 00:00:00

abstract：:Diffuse large-cell lymphoma (DLCL) is a neoplasm that is curable with chemotherapy in an appreciable percentage of patients. However, not all patients are cured and the best drug combination and optimal dose intensity have not yet been established. In an attempt to improve complete response rate and survival with mini...

journal_title：International journal of hematology

authors： Ohnoshi T,Hayashi K,Ueno K,Tada A,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Yoshino T

更新日期：1993-08-01 00:00:00

abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

journal_title：International journal of hematology

authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

更新日期：2015-08-01 00:00:00

abstract：:Thy-1 (CDw90) is a phosphatidylinositol-anchored protein, and is expressed on human pluripotential hematopoietic stem cells. The expression pattern of this antigen on leukemia cells is still controversial. In this study, 72 adult patients with pre-B cell acute lymphoblastic leukemia (pre-B ALL) were examined for the e...

journal_title：International journal of hematology

authors： Takahashi T,Mizutani M,Miwa H,Katayama N,Nishii K,Shikami M,Yamaguchi M,Shiku H,Kamada N,Kita K

更新日期：1998-06-01 00:00:00

abstract：:We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemi...

journal_title：International journal of hematology

authors： Minakata D,Fujiwara SI,Ikeda T,Kawaguchi SI,Toda Y,Ito S,Ochi SI,Nagayama T,Mashima K,Umino K,Nakano H,Yamasaki R,Morita K,Kawasaki Y,Sugimoto M,Yamamoto C,Ashizawa M,Hatano K,Sato K,Oh I,Ohmine K,Muroi K,Ohmo

更新日期：2019-02-01 00:00:00

abstract：:Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September...

journal_title：International journal of hematology

authors： Kitao A,Kawamoto S,Kurata K,Hayakawa I,Yamasaki T,Matsuoka H,Sumi Y,Kakeji Y,Kamesaki T,Minami H

更新日期：2020-05-01 00:00:00

abstract：:In order to better understand the biology of adult T cell leukemia (ATL), we aimed to establish a novel method, which allows the primary growth of ATL cells using a co-culture system with murine bone marrow-derived stromal cells, MS-5. ATL cells grew in close contact with MS-5 layers and formed so-called "cobblestone ...

journal_title：International journal of hematology

authors： Nagai K,Jinnai I,Hata T,Usui T,Sasaki D,Tsukasaki K,Sugahara K,Hishikawa Y,Yamada Y,Tanaka Y,Koji T,Mano H,Kamihira S,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). The treatment paradigm for MDS has changed in recent years with the introduction of hypomethylating agents (HMAs). The present retrospective multicenter study was designed...

journal_title：International journal of hematology

authors： Kim Y,Kim IH,Kim HJ,Park S,Lee KH,Kim SJ,Lee JH,Kim DY,Yoon SS,Kim YK,Jang JH,Park SY,Ahn JS,Cheong CW,Lee JH,Cheong JW,Korean Society of Hematology Acute myeloid Leukemia\/Myelodysplastic Syndrome Working Party.

更新日期：2014-01-01 00:00:00

abstract：:Immunosuppression (IS) therapy with antilymphocyte globulin (ALG) is currently the treatment of choice for patients with aplastic anemia who do not have histocompatible sibling donors or who are not candidates for allogeneic bone marrow transplantation. Thirty-eight patients with aplastic anemia who received ALG-based...

journal_title：International journal of hematology

authors： Feng YH,Yen CJ,Huang WT,Su WC,Chen TY,Tsao CJ

更新日期：2004-02-01 00:00:00

abstract：:We report a case of primary extramedullary plasmacytoma (PEMP), IgA kappa type, with a long clinical history, in a 64-year-old Japanese woman. In this case, PEMP occurred primarily in the jejunum and then recurred in several organs, specifically the spleen and stomach, and in the subcutaneous tissue, over a period of ...

journal_title：International journal of hematology

authors： Homma K,Ihzumi T,Nemoto K,Ohnishi Y

更新日期：1992-10-01 00:00:00

abstract：:Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...

journal_title：International journal of hematology

authors： Wang Z,Shi J,Zhou Y,Ruan C

更新日期：2001-02-01 00:00:00

abstract：:Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

journal_title：International journal of hematology

authors： Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

更新日期：2016-01-01 00:00:00

abstract：:The correlation between infant leukemia and in utero exposure to topoisomerase II (topo-II) inhibitor has been clarified. We examined the in vitro effect of topo-II inhibitor (etoposide) on cleavage of the MLL gene in cord and peripheral blood mononuclear cells (MNCs). Southern blot analysis showed cleavage of the MLL...

journal_title：International journal of hematology

authors： Ishii E,Eguchi M,Eguchi-Ishimae M,Yoshida N,Oda M,Zaitsu M,Fujita I,Miyazaki S,Hamasaki Y,Mizutani S

更新日期：2002-07-01 00:00:00

abstract：:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

journal_title：International journal of hematology

authors： Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

更新日期：2011-12-01 00:00:00

abstract：:A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...

journal_title：International journal of hematology

authors： Sakai A,Oda M,Itagaki M,Yoshida N,Arihiro K,Kimura A

更新日期：2010-11-01 00:00:00

abstract：:Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement o...

journal_title：International journal of hematology

authors： Iyama S,Murase K,Sato T,Hashimoto A,Tatekoshi A,Horiguchi H,Kamihara Y,Ono K,Kikuchi S,Takada K,Kawano Y,Hayashi T,Miyanishi K,Sato Y,Takimoto R,Kobune M,Mori S,Kato J,Yamashita T,Kato J

更新日期：2014-04-01 00:00:00

abstract：:Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...

journal_title：International journal of hematology

authors： Fu H,Xu L,Liu D,Zhang X,Liu K,Chen H,Wang Y,Han W,Han T,Huang X

更新日期：2013-07-01 00:00:00

abstract：:The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluo...

journal_title：International journal of hematology

authors： Oh MY,Chung JS,Song MK,Shin HJ,Lee HS,Lee SM,Lee GW,Lee SE

更新日期：2013-03-01 00:00:00

abstract：:miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reporte...

journal_title：International journal of hematology

authors： Kotaki R,Higuchi H,Ogiya D,Katahira Y,Kurosaki N,Yukihira N,Ogata J,Yamamoto H,Mohamad Alba S,Azhim A,Kitajima T,Inoue S,Morishita K,Ono K,Koyama-Nasu R,Kotani A

更新日期：2017-12-01 00:00:00

abstract：:Allogeneic stem cell transplantation is an established treatment modality for a variety of hematologic malignancies. Unfortunately it carries a high risk of complications and toxicities related to the intensive preparative regimen which is traditionally used for pre-transplant myeloablation and the graft versus host d...

journal_title：International journal of hematology

authors： Giralt S

更新日期：2002-08-01 00:00:00

abstract：:Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...

journal_title：International journal of hematology

authors： Harada-Shirado K,Wang X,Mori H,Fukatsu M,Takahashi H,Shichishima-Nakamura A,Kimura S,Ohkawara H,Yamada S,Ito T,Ikezoe T

更新日期：2020-03-01 00:00:00

abstract：:Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...

journal_title：International journal of hematology

authors： Okuda T,Tashima M,Tohi T,Ogawa K,Sawada H,Okuma M

更新日期：1993-08-01 00:00:00

abstract：:A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...

journal_title：International journal of hematology

authors： Sakamaki H,Ishizawa KI,Taniwaki M,Fujisawa S,Morishima Y,Tobinai K,Okada M,Ando K,Usui N,Miyawaki S,Utsunomiya A,Uoshima N,Nagai T,Naoe T,Motoji T,Jinnai I,Tanimoto M,Miyazaki Y,Ohnishi K,Iida S,Okamoto S,Seriu

更新日期：2009-04-01 00:00:00