Autologous hematopoietic stem cell transplantation for 3 patients with severe juvenile rheumatoid arthritis.

abstract：:Multicenter, prospective study was conducted to evaluate the efficacy of biweekly romiplostim in maintaining platelet ≥ 30 × 10(9)/L for at least 4 weeks. Treatment was started with a weekly injection (1 mcg/kg), and the dose was escalated until a titrated dose was achieved that maintained a platelet 50-200 × 10(9)/L ...

journal_title：International journal of hematology

authors： Park S,Yoon SS,Lee JH,Park JS,Jang JH,Lee JW

更新日期：2016-01-01 00:00:00

abstract：:Severe fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precurs...

journal_title：International journal of hematology

authors： Hübel K,Chemnitz J,Brochhagen HG,Cornely OA

更新日期：2004-04-01 00:00:00

abstract：:Under influence of hematopoietic growth factors, particularly thrombopoietin (TPO), hematopoietic stem cells in the bone marrow go through a process of commitment, proliferation, differentiation, and maturation and become mature megakaryocytes. At this critical point, terminally differentiated megakaryocytes face a ne...

journal_title：International journal of hematology

authors： Li J,Kuter DJ

更新日期：2001-12-01 00:00:00

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00

abstract：:CCR4 is expressed on tumor cells of most patients with adult T-cell leukemia/lymphoma (ATL). Gain-of-function mutations of the CCR4 gene in ATL patients may be associated with alterations at the carboxyl terminus, a finding which led to a high efficacy anti-CCR4 antibody, mogamulizumab. Only a few studies have reporte...

journal_title：International journal of hematology

authors： Sakamoto Y,Fujii K,Murase S,Nakano S,Masaki A,Murase T,Kusumoto S,Iida S,Utsunomiya A,Ueda R,Ishida T,Inagaki H

更新日期：2019-10-01 00:00:00

abstract：:Diffuse large-cell lymphoma (DLCL) is a neoplasm that is curable with chemotherapy in an appreciable percentage of patients. However, not all patients are cured and the best drug combination and optimal dose intensity have not yet been established. In an attempt to improve complete response rate and survival with mini...

journal_title：International journal of hematology

authors： Ohnoshi T,Hayashi K,Ueno K,Tada A,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Yoshino T

更新日期：1993-08-01 00:00:00

abstract：:Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...

journal_title：International journal of hematology

authors： Hosgood HD 3rd,Au WY,Kim HN,Liu J,Hu W,Tse J,Song B,Wong KF,Lee JJ,Chanock SJ,Siu LP,Purdue MP,Shin MH,Yu J,Liang R,Kim HJ,Rothman N,Lan Q

更新日期：2013-06-01 00:00:00

abstract：:Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous...

journal_title：International journal of hematology

authors： Okada K,Asakura S,Yano T,Kishimoto T

更新日期：2018-09-01 00:00:00

abstract：:The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...

journal_title：International journal of hematology

authors： Kang JY,Ha JH,Kang HS,Yoon HK,Kim HJ,Lee S,Lee DG,Jung JI,Kim SC,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...

journal_title：International journal of hematology

authors： Kuan JW,Su AT,Tay SP,Fong IL,Kubota S,Su'ut L,Osato M,Sashida G

更新日期：2020-02-01 00:00:00

abstract：:We report the results of unrelated cord blood transplantation (CBT) in a 12-year-old boy with Philadelphia chromosome- positive chronic myelogenous leukemia in the chronic phase and a high body weight (68.5 kg at transplantation). Only 1 of the 2 units used engrafted. This unit was not human leukocyte antigen (HLA) cl...

journal_title：International journal of hematology

authors： Hung GY,Chiou TJ,Chang CY,Teng HW,Chen PM,Hwanga B

更新日期：2005-08-01 00:00:00

abstract：:In order to better understand the biology of adult T cell leukemia (ATL), we aimed to establish a novel method, which allows the primary growth of ATL cells using a co-culture system with murine bone marrow-derived stromal cells, MS-5. ATL cells grew in close contact with MS-5 layers and formed so-called "cobblestone ...

journal_title：International journal of hematology

authors： Nagai K,Jinnai I,Hata T,Usui T,Sasaki D,Tsukasaki K,Sugahara K,Hishikawa Y,Yamada Y,Tanaka Y,Koji T,Mano H,Kamihira S,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...

journal_title：International journal of hematology

authors： Tomonari A,Iseki T,Ooi J,Takahashi S,Ishii K,Takahashi T,Shindo M,Nagamura F,Uchimaru K,Nagayama H,Shirafuji N,Tojo A,Tani K,Asano S

更新日期：2002-11-01 00:00:00

abstract：:The plasma levels of soluble urokinase-type plasminogen activator receptor (uPAR; CD87) measured by enzyme-linked immunosorbent assay were higher in patients with paroxysmal nocturnal hemoglobinuria (PNH) (5.8 +/- 4.7 ng/ml, mean +/- S.D., n = 9) than in normal donors (2.0 +/- 0.8 ng/ml, mean +/- S.D., n = 15). The hi...

journal_title：International journal of hematology

authors： Ninomiya H,Hasegawa Y,Nagasawa T,Abe T

更新日期：1997-04-01 00:00:00

abstract：:In the original publication of this article, Tables 2, 3 and 4 were published incorrectly. The corrected tables 2, 3 and 4 are given in the following pages. ...

journal_title：International journal of hematology

authors： Ueda Y,Obara N,Yonemura Y,Noji H,Masuko M,Seki Y,Wada K,Matsuda T,Akiyama H,Ikezoe T,Chiba S,Kanda Y,Kawaguchi T,Shichishima T,Nakakuma H,Okamoto S,Nishimura JI,Kanakura Y,Ninomiya H

更新日期：2018-08-01 00:00:00

abstract：:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

journal_title：International journal of hematology

authors： Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

更新日期：2019-06-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is a highly heterogeneous disease with an unpredictable pattern. CVID appears to have an immunologic and clinical phenotype similar to some hereditary humoral immunodeficiencies, including X-linked lymphoproliferative disease (XLP). The differential diagnosis of CVID and XLP is ...

journal_title：International journal of hematology

authors： Aghamohammadi A,Kanegane H,Moein M,Farhoudi A,Pourpak Z,Movahedi M,Gharagozlou M,Zargar AA,Miyawaki T

更新日期：2003-07-01 00:00:00

abstract：:CD4+CD25+Foxp3+ Treg is a functionally distinct subset of mature T cells with broad suppressive activity and has been shown to play an important role in the establishment of immune tolerance after HSCT. Altered cytokine environment in post-HSCT lymphopenia with a relative functional deficiency of IL-2 could hamper the...

journal_title：International journal of hematology

authors： Matsuoka KI

更新日期：2018-02-01 00:00:00

abstract：:Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...

journal_title：International journal of hematology

authors： Masui S

更新日期：2010-04-01 00:00:00

abstract：:Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

journal_title：International journal of hematology

authors： Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

更新日期：2014-03-01 00:00:00

abstract：:We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cel...

journal_title：International journal of hematology

authors： Kageyama T,Takiuchi H,Hasegawa M,Ohyabu H,Horiike S

更新日期：1991-06-01 00:00:00

abstract：:The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. However, some aspect...

journal_title：International journal of hematology

authors： Chen H,Qian S,Shi P,Liu L,Yang F

更新日期：2020-07-01 00:00:00

abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterized by an extreme susceptibility to Epstein-Barr virus (EBV) infection. Patients with XLP mainly present with the 3 clinical manifestations of fulminant infectious mononucleosis, lymphoproliferative disorder, and dysgammaglobulinemia...

journal_title：International journal of hematology

authors： Hoshino T,Kanegane H,Doki N,Irisawa H,Sakura T,Nojima Y,Miyawaki S,Miyawaki T

更新日期：2005-07-01 00:00:00

abstract：:We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, t...

journal_title：International journal of hematology

authors： Kitamura K,Nishiyama T,Ishiyama K,Miyawaki S,Miyazaki K,Suzuki K,Masaie H,Okada M,Ogawa H,Imai K,Kiyoi H,Naoe T,Yokoyama Y,Chiba S,Hata T,Miyazaki Y,Hatta Y,Takeuchi J,Nannya Y,Kurokawa M,Ueda Y,Koga D,Sugiyam

更新日期：2016-01-01 00:00:00

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimeris...

journal_title：International journal of hematology

authors： Hasegawa D,Fukushima M,Hosokawa Y,Takeda H,Kawasaki K,Mizukami T,Nunoi H,Ochiai H,Morio T,Kosaka Y

更新日期：2008-01-01 00:00:00

abstract：:Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...

journal_title：International journal of hematology

authors： Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini F

更新日期：2007-07-01 00:00:00

abstract：:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/P...

journal_title：International journal of hematology

authors： Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa T

更新日期：1993-04-01 00:00:00

abstract：:We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...

journal_title：International journal of hematology

authors： Shah AD,Watts AJ,Mehta AB,Wechalekar AD

更新日期：2010-01-01 00:00:00

abstract：:A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

journal_title：International journal of hematology

authors： Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

更新日期：2007-11-01 00:00:00

abstract：:The XCIND syndrome is named after distinct hypersensitivity to ionizing (X-ray) irradiation, cancer susceptibility, immunodeficiency, neurological abnormality, and double-strand DNA breakage. The disorders comprising XCIND syndrome are usually inherited in an autosomal recessive manner. Ataxia telangiectasia (A-T) is ...

journal_title：International journal of hematology

authors： Mizutani S,Takagi M

更新日期：2013-01-01 00:00:00