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Chromosomal abnormalities and oncogenes.

Abstract：

:The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associated with the chromosomal translocations found in acute myeloid leukemia, such as the AML1/MTG8 in t(8;21) and PML/RAR alpha in t(15;17). The latter is the main mechanism in the gene activations observed in acute lymphoblastic leukemia and lymphoma. Many transcription factor genes are activated by the recombination with the immunoglobulin genes in B cell malignancies or T cell receptor genes in T cell malignancies. We isolated the AML1/EVI-1 fusion gene generated by the t(3;21) translocation, which is usually found in blastic crisis of chronic myelocytic leukemia. The chimeric transcription factor encoded by the fusion gene has dual functions, namely differentiation block and stimulation of proliferation. These findings provide new insight into the molecular mechanism in leukemogenesis by the chimeric transcription factors.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Mitani K

doi

10.1016/0925-5710(96)00440-9

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

81-93

issue

2

eissn

0925-5710

issn

1865-3774

pii

0925571096004409

journal_volume

63

pub_type

杂志文章,评审

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