Role of Lipoprotein Apheresis in Cardiovascular Disease Risk Reduction.

Abstract:

BACKGROUND AND AIM:Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). Management of hypercholesterolemia consists of drug therapies, including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. In patients with familial hypercholesterolemia (FH), lipoprotein apheresis (LA) is utilized to control lipid levels. However, LA is not currently a standard therapy for non-FH. This review summarizes the literature regarding LA therapy in CVD prevention. METHODS:PubMed/MEDLINE databases were searched using the keywords "LA" and "CVD". Citations were individually reviewed for relevance. RESULTS:The efficacy of LA was clearly demonstrated, largely based on evidence from observational studies. In patients who are unresponsive to traditional lipid-lowering medications, LA effectively reduced serum lipoprotein levels and adverse cardiovascular events. CONCLUSION:It was concluded that LA is a safe and effective technique that could be considered in the management of hypercholesterolemia and future risk. Randomized control trials would further support a role for LA as a therapeutic option.

journal_name

Blood Purif

journal_title

Blood purification

authors

Raina R,Young C,Krishnappa V,Chanchlani R

doi

10.1159/000497447

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

301-316

issue

4

eissn

0253-5068

issn

1421-9735

pii

000497447

journal_volume

47

pub_type

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