Microcirculation: Physiology, Pathophysiology, and Clinical Application.

Abstract:

:This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory compromise in states of shock and renal compromise is discussed. Our introduction of hand-held vital microscopes (HVM) to clinical medicine has revealed the importance of the microcirculation as a central target organ in states of critical illness and inadequate response to therapy. Technical and methodological developments have been made in hardware and in software including our recent introduction and validation of automatic analysis software called MicroTools, which now allows point-of-care use of HVM imaging at the bedside for instant availability of functional microcirculatory parameters needed for microcirculatory targeted resuscitation procedures to be a reality.

journal_name

Blood Purif

journal_title

Blood purification

authors

Guven G,Hilty MP,Ince C

doi

10.1159/000503775

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

143-150

issue

1-2

eissn

0253-5068

issn

1421-9735

pii

000503775

journal_volume

49

pub_type

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