Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients.

Abstract:

BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color was assessed using a Mexameter that measures the melanin index (MI) and the erythema index (EI). The upper inner arms (non-sun-exposed site) and the foreheads (sun-exposed site) of HD and PD patients and control subjects were analyzed. RESULTS:MI values on the upper inner arms and on the foreheads of HD and PD patients were significantly higher than in controls. In HD patients, significant correlations were found for serum 5SCD levels with MI and EI on the upper inner arm, and for EI on the forehead. In PD patients, no such correlations were found. CONCLUSIONS:Hyperpigmentation in HD patients results partly from accumulation of pheomelanin in the skin.

journal_name

Blood Purif

journal_title

Blood purification

authors

Murakami K,Nakanishi Y,Wakamatsu K,Yamamoto K,Kohriyama N,Hasegawa M,Tomita M,Nabeshima K,Hiki Y,Asano S,Kawashima S,Ito Y,Fujita Y,Asada H,Nakai S,Sugiyama S,Ito S

doi

10.1159/000230812

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

209-15

issue

3

eissn

0253-5068

issn

1421-9735

pii

000230812

journal_volume

28

pub_type

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