Abstract:
:Elimination of uremic solutes with molecular weights up to 60 kD, without significant loss of albumin is an important therapeutic goal to optimize outcomes in chronic hemodialysis patients. To characterize a newly developed polysulfone dialyzer (APS-650) a comparative analysis was performed with a highly advanced polysulfone dialyzer (F-60S) including 22 stable chronic hemodialysis patients. Diffusive clearances were determined, and albumin loss was calculated. The elimination profile of uremic solutes up to 32.0 kD was assessed in vivo by sieving coefficients, clearances, and reduction ratios of beta(2)-microglobulin (11.8 kD), myoglobin (17.2 kD), prolactin (23.0 kD), and alpha(1)-microglobulin (32.0 kD). Hemocompatibility was tested in serial measurements of total white blood cell count, platelet count, C3a, and neutrophil elastase. No significant albumin loss was detected. Significantly higher sieving coefficients, clearances, and reduction ratios for proteins with molecular weight up to 32.0 kD were demonstrated with the newly developed polysulfone membrane. Both polysulfone membranes were equal concerning hemocompatibility parameters. The APS-650 dialyzer allowed optimized hemodialysis treatment with respect to clearance of medium-sized uraemic solutes by high-flux dialysis.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Klingel R,Ahrenholz P,Schwarting A,Röckel Adoi
10.1159/000063099subject
Has Abstractpub_date
2002-01-01 00:00:00pages
325-33issue
4eissn
0253-5068issn
1421-9735pii
63099journal_volume
20pub_type
杂志文章abstract::Backgound: This study was aimed at evaluating the presepsin and procalcitonin levels to predict adverse postoperative complications and mortality in cardiac surgery patients. METHODS:A total of 122 cardiac surgery patients were enrolled for the study. Presepsin and procalcitonin levels were measured 48 h after the pr...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000494207
更新日期:2019-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1159/000157325
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000322622
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pub_type: 杂志文章,多中心研究
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doi:10.1159/000445424
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journal_title:Blood purification
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1159/000014470
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journal_title:Blood purification
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1159/000287776
更新日期:2010-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000508060
更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000169475
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journal_title:Blood purification
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更新日期:2011-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000350839
更新日期:2013-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000014394
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014316
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00