Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion.

Abstract:

:In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoclonal plasma cell proliferative disorders), we analyzed the pre- and postdialysis levels of kappa- and lambda-chains. In group 1 we observed a significant reduction of FIgLCs (p < 0.01). A similar trend was found in patients of group 2 only for kappa-chains. The FIgLCs removal ratio was significantly higher for kappa- than lambda-chains in the two patient groups. In vitro data showed affinity of macroporous resin to binding FIgLCs. Our results show that the HFR therapy could be effective in removing FIgLCs, particularly kappa-chains in dialysis patients with polyclonal and monoclonal FIgLCs production.

journal_name

Blood Purif

journal_title

Blood purification

authors

Testa A,Dejoie T,Lecarrer D,Wratten M,Sereni L,Renaux JL

doi

10.1159/000316684

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

34-6

issue

1

eissn

0253-5068

issn

1421-9735

pii

000316684

journal_volume

30

pub_type

杂志文章
  • Advanced glycation end products and β(2)-microglobulin as predictors of carpal tunnel syndrome in hemodialysis patients.

    abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338923

    authors: Busch M,Schwenzky A,Franke S,Stein G,Wolf G

    更新日期:2012-01-01 00:00:00

  • Calcimimetics versus vitamin D: what are their relative roles?

    abstract::A strict control of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) is indicated to avoid serious complications linked to osteitis fibrosa and other parathyroid-hormone (PTH)-related bodily disturbances. However, such a control is often achieved only at the price of unacceptably high plasma...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000074922

    authors: Drüeke TB

    更新日期:2004-01-01 00:00:00

  • Dialysate Calcium Levels: Do They Matter?

    abstract:BACKGROUND:Calcium (Ca) is an essential element that plays a critical role in many biological processes. In dialysis patients, the regulation of Ca balance is highly complex, given the absence of kidney function, endocrine disturbances and the use of drugs such as phosphate binders, vitamin D analogues, and calcimimeti...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000494584

    authors: van der Sande FM,Ter Meulen KJA,Kotanko P,Kooman JP

    更新日期:2019-01-01 00:00:00

  • Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

    abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000493178

    authors: Leypoldt JK,Vonesh EF

    更新日期:2019-01-01 00:00:00

  • Severe Secondary Hyperparathyroidism in a Hemodialysis Patient: A Case Report from Mongolia.

    abstract::Secondary hyperparathyroidism (SHPT) occurs in patients with chronic renal failure complicated with renal bone disease and soft tissue/vascular calcification. In dialysis patients with severe SHPT, medical treatment may fail and parathyroidectomy (PTX) is indicated for definitive treatment. Severe hypocalcemia from hu...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000479616

    authors: Adiya S,Damdinsuren K,Dorj C

    更新日期:2017-01-01 00:00:00

  • Intradialytic cytokine gene expression.

    abstract::Along with the numerous technological improvements in molecular biology, polymerase chain reaction, which permits analysis of sequences of a very small amount of biological material, enables evaluation of hemodialysis-induced gene transcription of inflammatory cytokines. Blood samples drawn from 22 hemodialysis patien...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014310

    authors: Roccatello D,Menegatti E,Alfieri V,Rossi D,DeLuca A,Pignone E,Mengozzi G,Cesano G,Formica M,Martina G,Sena LM,Piccoli G

    更新日期:1998-01-01 00:00:00

  • What can we expect from on-line hemodiafiltration?

    abstract::On-line hemodiafiltration (ol-HDF) may improve clinical outcome in ESRD. The supposed mechanism is the improved clearance of uremic toxins by convective transport which is added to the diffusion transport. However, recent marked improvement in the performance of dialyzers has allowed higher removal rate of middle to l...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000346217

    authors: Kawanishi H

    更新日期:2013-01-01 00:00:00

  • When should renal replacement therapy for acute kidney injury be initiated and discontinued?

    abstract:BACKGROUND:Critically ill patients with acute kidney injury (AKI) are at high risk for death and frequently require initiation of renal replacement therapy (RRT). There is wide variation in clinical practice on the indications for and timing of initiation and discontinuation of RRT. Numerous clinical and biochemical fa...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000157325

    authors: Gibney RT,Bagshaw SM,Kutsogiannis DJ,Johnston C

    更新日期:2008-01-01 00:00:00

  • End-stage renal failure patients requiring renal replacement therapy in the intensive care unit: incidence, clinical features, and outcome.

    abstract:AIMS:To study incidence, clinical features, and outcome of critically ill patients with end-stage renal failure (ESRF) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) and to test the validity of severity scoring systems for these patients. METHODS:Data for ESRF patients treated with RRT were...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000069156

    authors: Uchino S,Morimatsu H,Bellomo R,Silvester W,Cole L

    更新日期:2003-01-01 00:00:00

  • In vitro clearance and hemocompatibility assessment of ultrathin nanoporous silicon membranes for hemodialysis applications using human whole blood.

    abstract:BACKGROUND/AIMS:Recent advances in nanotechnology have made it possible to mass-produce ultrathin silicon membranes with pore sizes in the range of nanometers. In this study, we investigate the possibility of employing ultrathin nanoporous silicon membranes with pore diameters of 5 and 20 nm for dialysis of human whole...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000350613

    authors: Ahmadi M,Gorbet M,Yeow JT

    更新日期:2013-01-01 00:00:00

  • Amino acids and keto acids in the treatment of chronic renal failure.

    abstract::Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,评审

    doi:10.1159/000169557

    authors: Jungers P,Chauveau P

    更新日期:1988-01-01 00:00:00

  • The Role of Dialysis Membranes on Intradialytic Selenium Removal and on Selenium Status in Patients Receiving Renal Replacement Therapy.

    abstract:BACKGROUND/AIMS:Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. METHODS:We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethyl...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000441438

    authors: Sonikian M,Dona A,Skarakis J,Trompouki S,Miha T,Karatzas I,Spiliopoulou C

    更新日期:2016-01-01 00:00:00

  • Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients.

    abstract:BACKGROUND:Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. OBJECTIVES:To validate p...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000500423

    authors: Fiorentino M,Tohme FA,Murugan R,Kellum JA

    更新日期:2019-01-01 00:00:00

  • Choosing a treatment modality for the infant, child and adolescent with endstage renal disease.

    abstract::The factors involved in choosing a treatment modality for the infant, child and adolescent with endstage renal disease (ESRD) are different than those utilized when counseling an adult patient. Age at the time ESRD develops, mental status, psychosocial status and the primary renal disease must be taken into considerat...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169450

    authors: Fine RN

    更新日期:1987-01-01 00:00:00

  • Proteome patterns in uremic plasma.

    abstract::In patients with chronic kidney disease (CKD), peptides and proteins circulate at altered concentrations versus in healthy individuals. We have characterized proteome samples from 7 pooled CKD stage 5 patients not yet on dialysis and with no known co-morbidities. We also analyzed pooled plasma samples from 7 healthy a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000178773

    authors: Naseeb U,Shafqat J,Jägerbrink T,Zarina S,Alvestrand A,Jörnvall H,Axelsson J

    更新日期:2008-01-01 00:00:00

  • Comparison of bioimpedance and clinical methods for dry weight prediction in maintenance hemodialysis patients.

    abstract:BACKGROUND:Bioelectrical impedance analysis (BIA) is a promising technique to evaluate dry weight. We compared the dry weight calculated by the three BIA equations Carlo Basile (CB) , Yanna Dou (YD) and the body composition spectroscopy (BCS) with clinical evaluation in maintenance hemodialysis (MHD) patients. METHODS...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000362109

    authors: Jian Y,Li X,Cheng X,Chen Y,Liu L,Tao Z,Zuo L

    更新日期:2014-01-01 00:00:00

  • Effects of hemoadsorption with a novel adsorbent on sepsis: in vivo and in vitro study.

    abstract:BACKGROUND/AIMS:Hemoadsorption may improve outcomes for sepsis by removing circulating cytokines. We tested a new sorbent used for hemoadsorption. METHODS:CTR sorbent beads were filled into columns of three sizes: CTR0.5 (0.5 ml), CTR1 (1.0 ml) and CTR2 (2.0 ml) and tested using IL-6 capture in vitro. Next, rats were ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000381006

    authors: Zhang J,Peng Z,Maberry D,Volpe J,Kimmel JD,Federspiel WJ,Kellum JA

    更新日期:2015-01-01 00:00:00

  • Plasmapheresis for the Treatment of Acute Pancreatitis due to Severe Hypertriglyceridemia.

    abstract::Severe hypertriglyceridemia (HTG) is associated with acute pancreatitis (AP). Treatment options include total plasma exchange (TPE). We report a case of AP due to severe HTG treated with TPE. ...

    journal_title:Blood purification

    pub_type:

    doi:10.1159/000510647

    authors: Ruiz-Rodríguez JC,Chiscano-Camón LS,Palmada C,Pons V,Ferrer R

    更新日期:2020-11-24 00:00:00

  • New polyether sulfone dialyzers attenuate passage of cytokine-inducing substances from pseudomonas aeruginosa contaminated dialysate.

    abstract::The use of bicarbonate dialysate and high-flux and reprocessed dialyzers has raised concerns about the reverse transfer of dialysate contaminants into the blood compartment. This in vitro study was performed to investigate the reverse transfer of soluble Pseudomonas aeruginosa bacterial products across a polyether sul...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014336

    authors: Jaber BL,Gonski JA,Cendoroglo M,Balakrishnan VS,Razeghi P,Dinarello CA,Pereira BJ

    更新日期:1998-01-01 00:00:00

  • Intravenous iron sucrose changes the intraperitoneal homeostasis.

    abstract:BACKGROUND/AIMS:Intravenous iron infusion is the accepted way of supplementation of that compound in uremic patients. The aim of the study was to evaluate whether this treatment affects intraperitoneal homeostasis in patients on peritoneal dialysis. METHODS:Blood and peritoneal dialysate samples were collected from 10...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000210038

    authors: Breborowicz A,Połubinska A,Kupczyk M,Wanic-Kossowka M,Oreopoulos DG

    更新日期:2009-01-01 00:00:00

  • Effects of calcitriol on type 5b tartrate-resistant acid phosphatase and interleukin-6 in secondary hyperparathyroidism.

    abstract:BACKGROUND/AIMS:Secondary hyperparathyroidism (SHP) is characterized by high bone turnover and elevated serum bone remodeling markers. Elevation of serum interleukin-6 (IL-6) levels is also characteristic of end-stage renal disease. This study investigates the effects of intravenous calcitriol on serum bone resorptive ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000094899

    authors: Lu KC,Tseng CF,Wu CC,Yeung LK,Chen JS,Chao TY,Janckila AJ,Yam LT,Chu P

    更新日期:2006-01-01 00:00:00

  • Benefit of glucose-free dialysis solutions on glucose and lipid metabolism in peritoneal dialysis patients.

    abstract:BACKGROUND:Glucose absorbed from conventional peritoneal dialysis (PD) solutions contributes to unfavorable metabolic effects. Its replacement with a glucose-free osmotic agent such as icodextrin (ID) or amino acids (AA) may have some benefit on glucose and lipid metabolism. METHODS:Serum lipids, insulin sensitivity a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000086553

    authors: Martikainen T,Teppo AM,Gronhagen-Riska C,Ekstrand A

    更新日期:2005-01-01 00:00:00

  • Arteriovenous hemodiafiltration associated with continuous arteriovenous hemofiltration: a combined therapy for acute renal failure in the hypercatabolic patient.

    abstract::To increase the efficiency of continuous arteriovenous hemofiltration (CAVH) in cases of severe catabolism, we used a modified CAVH treatment, called arteriovenous hemodiafiltration (AVHDF), in 4 patients. The transport of solutes was increased by providing the infusion of a counter current flow of urea-free solutions...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169454

    authors: Ronco C,Brendolan A,Bragantini L,Chiaramonte S,Fabris A,Feriani M,Dell'Aquila R,Milan M,La Greca G

    更新日期:1987-01-01 00:00:00

  • Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients.

    abstract:BACKGROUND:Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality i...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000366124

    authors: João Matias P,Azevedo A,Laranjinha I,Navarro D,Mendes M,Ferreira C,Amaral T,Jorge C,Aires I,Gil C,Ferreira A

    更新日期:2014-01-01 00:00:00

  • Peritoneal dialysis in Europe: an analysis of its rise and fall.

    abstract::There is a wide variability in the utilization of peritoneal dialysis throughout Europe that cannot be explained by differences in medical factors alone. Over the last years, the utilization of peritoneal dialysis has even changed in individual countries. The main factors of this variation are not medical, but rather ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000089446

    authors: Lameire N,Peeters P,Vanholder R,Van Biesen W

    更新日期:2006-01-01 00:00:00

  • Organ cross talk in the critically ill: the heart and kidney.

    abstract::Heart failure results in significant morbidity and mortality in the United States. Chronic heart failure is often complicated by renal insufficiency. Further, acute decompensated heart failure is often complicated by worsening renal function or the development of diuretic resistance. Heart failure complicated by renal...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000207198

    authors: Kociol R,Rogers J,Shaw A

    更新日期:2009-01-01 00:00:00

  • Ischemic Heart Disease in Patients with End-Stage Kidney Disease.

    abstract:BACKGROUND:It was recently reported that the severity of coronary and carotid atherosclerosis in patients with end-stage kidney disease (ESKD) has improved over the last two decades. However, the frequency of coronary artery events observed at the initiation of dialysis remains high. SUMMARY:Recently, 5 different clin...

    journal_title:Blood purification

    pub_type: 评论,杂志文章

    doi:10.1159/000441582

    authors: Tanaka Y,Joki N,Hase H

    更新日期:2015-01-01 00:00:00

  • Electrocardiographic changes during hemodiafiltration with different potassium removal rates.

    abstract:BACKGROUND/AIMS:Sudden K removal is thought to be implicated in ECG alterations observed during hemodialysis (HD). The effects of the K removal rate on ECG-derived parameters have been investigated. METHODS:Two different hemodiafiltration (HDF) schedules were used for 10 HD patients: the dialysate K concentration was ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000073440

    authors: Severi S,Vecchietti S,Cavalcanti S,Mancini E,Santoro A

    更新日期:2003-01-01 00:00:00

  • Improvements in technology: a path to safer and more effective hemodialysis.

    abstract::Effective dialysis therapy is now understood to encompass both small and large solute removal, using approaches that minimize intradialytic symptoms and maximize patient safety. Achieving the goal of providing effective dialysis for an expanding population of patients with increasingly complex medical problems at a ti...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000167001

    authors: Ward RA,Ronco C

    更新日期:2009-01-01 00:00:00

  • Long-term on-line hemodiafiltration reduces predialysis beta-2-microglobulin levels in chronic hemodialysis patients.

    abstract:BACKGROUND:Hemodiafiltration (HDF) is effective in delaying the surgical need for carpal tunnel syndrome in chronic hemodialysis patients, however, predialysis beta(2)-microglobulin levels were not reduced in most short-term studies. The aim of this study was to assess the effect of long-term and differing frequencies ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000046958

    authors: Lin CL,Yang CW,Chiang CC,Chang CT,Huang CC

    更新日期:2001-01-01 00:00:00