Abstract:
BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS. β2M in serum was determined by a competitive enzyme-linked immunoassay, CML by a competitive enzyme-linked immunosorbent assay and total pentosidine by reverse-phase high-performance liquid chromatography. RESULTS:127 patients (33%) were treated with biocompatible membranes, 174 (45%) with high-flux dialysis. 122 patients (31.7%) had clinical signs of CTS. Significant predictors of CTS were: age, female gender, serum β2M, total protein, dialysis with non-biocompatible high-flux dialysis compared to non-biocompatible low-flux dialysis, Kt/V and serum concentration of CML (OR 2.47 for the 3rd vs. 1st quartile, 95% CI 1.229-4.961, p = 0.011). CONCLUSION:The prevalence of CTS as a possible manifestation of dialysis-related amyloidosis is still high. Serum concentration of CML may be a predictor of CTS besides β2M and malnutrition.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Busch M,Schwenzky A,Franke S,Stein G,Wolf Gdoi
10.1159/000338923subject
Has Abstractpub_date
2012-01-01 00:00:00pages
3-9issue
1eissn
0253-5068issn
1421-9735pii
000338923journal_volume
34pub_type
杂志文章abstract::There is a wide variability in the utilization of peritoneal dialysis throughout Europe that cannot be explained by differences in medical factors alone. Over the last years, the utilization of peritoneal dialysis has even changed in individual countries. The main factors of this variation are not medical, but rather ...
journal_title:Blood purification
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000167011
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000345186
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pub_type: 杂志文章
doi:10.1159/000330891
更新日期:2012-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000046958
更新日期:2001-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000081871
更新日期:2004-01-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169955
更新日期:1990-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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