The Role of Dialysis Membranes on Intradialytic Selenium Removal and on Selenium Status in Patients Receiving Renal Replacement Therapy.

Abstract:

BACKGROUND/AIMS:Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. METHODS:We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethylene vinyl alcohol membrane (group B), 12 patients on hemodiafiltration (HDF; group C) and 16 healthy subjects (control group D). Se was measured in blood before and after dialysis session and in effluent dialysate every hour during session. RESULTS:In all patients together, pre-dialysis serum Se levels were lower than those in control group, but, in a separate analysis, only in standard HD. In all patient groups, there was a net Se removal into dialysate but it was greater in HDF patients who, however, had similar pre-dialysis serum Se levels to those in healthy controls. CONCLUSION:An intradialytic Se loss was found with all 3 membrane types, but it is not the principal factor for Se depletion in HD.

journal_name

Blood Purif

journal_title

Blood purification

authors

Sonikian M,Dona A,Skarakis J,Trompouki S,Miha T,Karatzas I,Spiliopoulou C

doi

10.1159/000441438

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

94-9

issue

1-3

eissn

0253-5068

issn

1421-9735

pii

000441438

journal_volume

41

pub_type

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