Impact of hemodialysis therapy on anemia of chronic kidney disease: the potential mechanisms.

Abstract:

:A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to understand the underlying mechanisms that contribute to the purported benefits of OL-HDF, we examined the potential role and impact of OL-HDF on key stages of anemia and its correction: erythropoiesis of bone marrow, circulating erythrocytes and on anemia therapy. We review evidence that indicates OL-HDF may modulate key processes of anemia and its therapy, including underlying conditions and responses of uremic toxicity and inflammation that aggravate anemia. Our assessment indicates that OL-HDF favorably impacts anemia by not only eliminating putative uremic inhibitors that suppress erythropoiesis, reducing red cell destruction and increasing iron availability, but also by mechanisms restricting underlying inflammation and endothelial dysfunction that are crucial to both CKD and anemia.

journal_name

Blood Purif

journal_title

Blood purification

authors

Bowry SK,Gatti E

doi

10.1159/000329573

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

210-9

issue

3

eissn

0253-5068

issn

1421-9735

pii

000329573

journal_volume

32

pub_type

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