Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant.

Abstract:

BACKGROUND/AIMS:Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. METHODS:We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane and verified its anticoagulation efficiency and its influence on coagulation markers such as activated partial thromboplastin time (aPTT), D-dimer and thrombin-antithrombin complex (TAT) in an animal HD model. RESULTS:All HD sessions with the argatroban dialyzer were completed successfully with either no or minimal fiber clotting. D-dimer was lower in the argatroban group than in the PAN group; TAT and aPTT values were similar in the two groups, which suggests better anticoagulation and a similar influence on the coagulation system. CONCLUSION:HD with the argatroban dialyzer is feasible, safe and simple, and could be used in patients at high risk of bleeding.

journal_name

Blood Purif

journal_title

Blood purification

authors

Zhang Y,Ning J,Veeraragoo P,Li Y,Dai S

doi

10.1159/000336094

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

300-6

issue

4

eissn

0253-5068

issn

1421-9735

pii

000336094

journal_volume

33

pub_type

杂志文章
  • Methylation status of immune response genes promoters in cell-free DNA differs in hemodialyzed patients with diabetic nephropathy according to the intensity of anemia therapy.

    abstract:BACKGROUND:Anemia is a major complication of end-stage renal disease. Hemodialysis itself is regarded as a stimulus activating inflammation. Pro-inflammatory cytokines are able to suppress erythropoiesis. In this pilot study, we analyzed the changes in methylation status of promoters of immune response genes in cell-fr...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000356094

    authors: Korabecna M,Pazourkova E,Horinek A,Mokrejsova M,Tesar V

    更新日期:2013-01-01 00:00:00

  • Leveraging Big Data and Electronic Health Records to Enhance Novel Approaches to Acute Kidney Injury Research and Care.

    abstract::While acute kidney injury (AKI) has been poorly defined historically, a decade of effort has culminated in a standardized, consensus definition. In parallel, electronic health records (EHRs) have been adopted with greater regularity, clinical informatics approaches have been refined, and the field of EHR-enabled care ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000458751

    authors: Sutherland SM,Goldstein SL,Bagshaw SM

    更新日期:2017-01-01 00:00:00

  • Intradialytic cytokine gene expression.

    abstract::Along with the numerous technological improvements in molecular biology, polymerase chain reaction, which permits analysis of sequences of a very small amount of biological material, enables evaluation of hemodialysis-induced gene transcription of inflammatory cytokines. Blood samples drawn from 22 hemodialysis patien...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014310

    authors: Roccatello D,Menegatti E,Alfieri V,Rossi D,DeLuca A,Pignone E,Mengozzi G,Cesano G,Formica M,Martina G,Sena LM,Piccoli G

    更新日期:1998-01-01 00:00:00

  • Ischemic Heart Disease in Patients with End-Stage Kidney Disease.

    abstract:BACKGROUND:It was recently reported that the severity of coronary and carotid atherosclerosis in patients with end-stage kidney disease (ESKD) has improved over the last two decades. However, the frequency of coronary artery events observed at the initiation of dialysis remains high. SUMMARY:Recently, 5 different clin...

    journal_title:Blood purification

    pub_type: 评论,杂志文章

    doi:10.1159/000441582

    authors: Tanaka Y,Joki N,Hase H

    更新日期:2015-01-01 00:00:00

  • Novel insights into the pathobiology of the vascular access - do they translate into improved care?

    abstract::While recent developments have allowed greater insight into the vascular pathobiology and intimal hyperplasia, very few of these advances have led to improved clinical care of hemodialysis vascular accesses. Indeed the most common procedure for the treatment of access stenosis and thrombosis is the same model for the ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000245650

    authors: Diskin CJ

    更新日期:2010-01-01 00:00:00

  • What is the role of controls in an outpatient department on progression of renal disease?

    abstract::Evidence that protein restriction retards the progression of chronic renal failure in man is mostly derived from anecdotic data and retrospective studies with inappropriate controls and inferior methodology for evaluating renal function. Data from a prospective randomized study in Stockholm demonstrate that more frequ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000169562

    authors: Bergström J,Alvestrand A,Bucht H,Gutierrez A

    更新日期:1988-01-01 00:00:00

  • Pathogenesis and management of upper-extremity ischemia following angioaccess surgery.

    abstract::Thirty-four patients with end-stage renal disease requiring hemodialysis developed over the course of 7 years (1987-1994) severe ischemia in the extremity carrying the angioaccess secondary to arterial 'steal'. Seven of these patients were treated with access ligation, 4 with banding reducing the flow through the acce...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170286

    authors: Haimov M,Schanzer H,Skladani M

    更新日期:1996-01-01 00:00:00

  • Acute suppression of parathyroid activity during hemofiltration.

    abstract::Hemofiltration (HF) induces a significant reduction in parathormone (PTH). This effect is related not only to the convective removal of PTH molecules but also to the biological suppression of parathyroid glands by plasma-ionized calcium (iCa) increase. The acute inhibitory effect on parathyroid gland activity, ionized...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170236

    authors: Panichi V,Bianchi AM,Andreini B,Casarosa L,Migliori M,De Pietro S,Ferdeghini M,Palla R

    更新日期:1996-01-01 00:00:00

  • Haemodialysis fluid: composition and clinical importance.

    abstract::Dialysis fluid is produced by the blending of treated water with electrolytes at the patients bed side. Its preparation and composition are important elements of treatment optimisation since many of the constituents play a role in patient well-being. Ideally the composition of the dialysis fluid should match that of p...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000096400

    authors: Hoenich NA,Ronco C

    更新日期:2007-01-01 00:00:00

  • Chronic kidney disease and the transplant recipient.

    abstract::The recent Kidney Disease Outcomes Quality Initiative (K/DOQI) classification of chronic kidney disease (CKD) includes transplant recipients. Although there are important differences between kidney transplant recipients (KTRs) and patients with native kidney disease, the inclusion of KTRs along with other CKD patients...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000067871

    authors: Gill JS,Pereira BJ

    更新日期:2003-01-01 00:00:00

  • Polymorphonuclear oxygen free radical production and complement activation induced by dialysis membranes as assayed in an experimental model.

    abstract::Activation of polymorphonuclear leukocytes with subsequent production of reactive oxygen metabolites has been reported to occur during hemodialysis related to a membrane bioincompatibility. We used an experimental dialysis model to evaluate, by chemiluminescence, the production of reactive oxygen metabolites and, by C...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169604

    authors: Cappelli G,Lucchi L,Bonucchi D,Cenci AM,Montagnani G,De Palma M,Lusvarghi E

    更新日期:1989-01-01 00:00:00

  • Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality?

    abstract::Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical condition...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000360520

    authors: Kanbay M,Solak Y,Gaipov A,Takir M,Weiner DE

    更新日期:2014-01-01 00:00:00

  • The Effect of Increased Frequency of Hemodialysis on Volume-Related Outcomes: A Secondary Analysis of the Frequent Hemodialysis Network Trials.

    abstract::In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and...

    journal_title:Blood purification

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000441966

    authors: Raimann JG,Chan CT,Daugirdas JT,Depner T,Gotch FA,Greene T,Kaysen GA,Kliger AS,Kotanko P,Larive B,Lindsay R,Rocco MV,Chertow GM,Levin NW,Frequent Hemodialysis Network (FHN) Trial Group.

    更新日期:2016-01-01 00:00:00

  • Severe Secondary Hyperparathyroidism in a Hemodialysis Patient: A Case Report from Mongolia.

    abstract::Secondary hyperparathyroidism (SHPT) occurs in patients with chronic renal failure complicated with renal bone disease and soft tissue/vascular calcification. In dialysis patients with severe SHPT, medical treatment may fail and parathyroidectomy (PTX) is indicated for definitive treatment. Severe hypocalcemia from hu...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000479616

    authors: Adiya S,Damdinsuren K,Dorj C

    更新日期:2017-01-01 00:00:00

  • Management of acute decompensated heart failure: renal implications.

    abstract::Heart failure (HF) is a chronic disease process associated with significant morbidity and mortality. Hospitalizations for acute decompensation may be frequent and herald a downward trajectory for the underlying disease state and overall poor prognosis for the patient. While significant advances have been made in the r...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000110558

    authors: Virani SA

    更新日期:2008-01-01 00:00:00

  • Deployment of a New CRRT/PIRRT Device during the COVID-19 Pandemic Emergency: Organizational Challenges and Implementation Results.

    abstract:INTRODUCTION:The coronavirus disease 2019 (COVID-19) pandemic led to increased demand nationwide for dialysis equipment, including supplies and machines. To meet the demand in our institution, our surge plan included rapid mobilization of a novel continuous renal replacement treatment (CRRT) machine named SAMI. The SAM...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000511726

    authors: Yessayan LT,Heung M,Girard FA,Shaikhouni S,Szamosfalvi B

    更新日期:2020-11-10 00:00:00

  • Intestinal-renal syndrome: mirage or reality?

    abstract::The recent interest in the role of the intestine in the cardiovascular stability of uremic patients, specifically on dialysis, but potentially also in chronic kidney disease, must be seen against the background of the recent great interest in the role of the gut in chronic heart failure [Curr Opin Clin Nutr Metab Care...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000321848

    authors: Ritz E

    更新日期:2011-01-01 00:00:00

  • Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients.

    abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000230812

    authors: Murakami K,Nakanishi Y,Wakamatsu K,Yamamoto K,Kohriyama N,Hasegawa M,Tomita M,Nabeshima K,Hiki Y,Asano S,Kawashima S,Ito Y,Fujita Y,Asada H,Nakai S,Sugiyama S,Ito S

    更新日期:2009-01-01 00:00:00

  • High Ferritin Level and Malnutrition Predict High Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study.

    abstract:AIMS:The aim of the study was to clarify the relationship between serum ferritin and infectious risks. METHODS:We evaluated all hospital admissions due to infections, clinical biomarkers and nutrition status in 129 incident Japanese dialysis patients during a median follow-up of 38 months. RESULTS:Kaplan-Meier analys...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000445424

    authors: Kato S,Lindholm B,Yuzawa Y,Tsuruta Y,Nakauchi K,Yasuda K,Sugiura S,Morozumi K,Tsuboi N,Maruyama S

    更新日期:2016-01-01 00:00:00

  • Recovery Time after Hemodialysis Is Inversely Associated with the Ultrafiltration Rate.

    abstract:INTRODUCTION:The present study aimed to determine the variables that are associated with a longer dialysis recovery time (DRT) and to define the relationship that exists between DRT and the ultrafiltration rate (UFR) in prevalent chronic hemodialysis (CHD) patients. METHODS:We studied 210 prevalent CHD of 5 hemodialys...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000492919

    authors: Bossola M,Di Stasio E,Monteburini T,Parodi E,Ippoliti F,Cenerelli S,Santarelli S,Nebiolo PE,Sirolli V,Bonomini M,Antocicco M,Zuccalà G,Laudisio A

    更新日期:2019-01-01 00:00:00

  • Electrocardiographic changes during hemodiafiltration with different potassium removal rates.

    abstract:BACKGROUND/AIMS:Sudden K removal is thought to be implicated in ECG alterations observed during hemodialysis (HD). The effects of the K removal rate on ECG-derived parameters have been investigated. METHODS:Two different hemodiafiltration (HDF) schedules were used for 10 HD patients: the dialysate K concentration was ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000073440

    authors: Severi S,Vecchietti S,Cavalcanti S,Mancini E,Santoro A

    更新日期:2003-01-01 00:00:00

  • Association between vitamin D receptor gene polymorphisms and susceptibility to chronic kidney disease and periodontitis.

    abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of severa...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000109235

    authors: de Souza CM,Braosi AP,Luczyszyn SM,Avila AR,de Brito RB Jr,Ignácio SA,Probst CM,Riella MC,Sotomaior VS,Mira MT,Pecoits-Filho R,Trevilatto PC

    更新日期:2007-01-01 00:00:00

  • The Rise of Expanded Hemodialysis.

    abstract::The low water permeability feature of original cellulosic membranes was considered an advantage in the absence of dialysis equipment that are capable of controlling water removal. The advent of ultrafiltration control systems led to the development and use of high-flux (HF) membranes that allowed improved middle molec...

    journal_title:Blood purification

    pub_type: 社论

    doi:10.1159/000476012

    authors: Ronco C

    更新日期:2017-01-01 00:00:00

  • In vitro clearance and hemocompatibility assessment of ultrathin nanoporous silicon membranes for hemodialysis applications using human whole blood.

    abstract:BACKGROUND/AIMS:Recent advances in nanotechnology have made it possible to mass-produce ultrathin silicon membranes with pore sizes in the range of nanometers. In this study, we investigate the possibility of employing ultrathin nanoporous silicon membranes with pore diameters of 5 and 20 nm for dialysis of human whole...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000350613

    authors: Ahmadi M,Gorbet M,Yeow JT

    更新日期:2013-01-01 00:00:00

  • Significance of Content of the Reticulocyte Hemoglobin in the Management of Renal Anemia.

    abstract::Optimal iron level in hemodialysis patients remains a subject of debate. The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow. CHr is not influenced by any factors that measure direct hemoglobin (Hb) of reticulocytes and...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000496641

    authors: Ogawa C,Tsuchiya K,Nitta K,Maeda K

    更新日期:2019-01-01 00:00:00

  • Angiotensin Converting Enzyme Inhibitor Dialyzability and Outcomes in Older Patients Receiving Hemodialysis.

    abstract:BACKGROUND/AIMS:Some angiotensin converting enzyme (ACE) inhibitors are efficiently removed from circulation by hemodialysis ('high dialyzability'), whereas others are not ('low dialyzability'). In patients receiving hemodialysis, this may influence the effectiveness of ACE inhibitors. METHODS:Using linked healthcare ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000438821

    authors: Weir MA,Fleet JL,Dixon SN,Jain AK,Oliver M,Wald R,McIntyre C,Garg AX

    更新日期:2015-01-01 00:00:00

  • Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.

    abstract::Tranquilizers, analgetics and antidepressants are applied in different ranges in the treatment of patients on hemodialysis. Due to many different pharmacokinetic properties, no perfect rules for dosage in acute or chronic hemodialysis exist. Adequate applicable drugs without adaptation disregarding different states of...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169404

    authors: Forycki Z,Martens F,Thalhofer S,Ibe K

    更新日期:1985-01-01 00:00:00

  • Advanced glycation end products and β(2)-microglobulin as predictors of carpal tunnel syndrome in hemodialysis patients.

    abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338923

    authors: Busch M,Schwenzky A,Franke S,Stein G,Wolf G

    更新日期:2012-01-01 00:00:00

  • Homocysteine as a cardiovascular risk factor.

    abstract:UNLABELLED:Hyperhomocysteinemia (HH), a known risk factor for vascular diseases, is a frequent condition in hemodialysis (HD) patients. HH induces an oxidant stress to the vascular endothelium, causing a failure of vasodilation and an impairment of the antithrombotic properties. Vitamins B(6), B(12) and folic acid are ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000014416

    authors: Biasioli S,Schiavon R

    更新日期:2000-01-01 00:00:00

  • End-stage renal failure patients requiring renal replacement therapy in the intensive care unit: incidence, clinical features, and outcome.

    abstract:AIMS:To study incidence, clinical features, and outcome of critically ill patients with end-stage renal failure (ESRF) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) and to test the validity of severity scoring systems for these patients. METHODS:Data for ESRF patients treated with RRT were...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000069156

    authors: Uchino S,Morimatsu H,Bellomo R,Silvester W,Cole L

    更新日期:2003-01-01 00:00:00