Abstract:
BACKGROUND/AIMS:Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. METHODS:We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane and verified its anticoagulation efficiency and its influence on coagulation markers such as activated partial thromboplastin time (aPTT), D-dimer and thrombin-antithrombin complex (TAT) in an animal HD model. RESULTS:All HD sessions with the argatroban dialyzer were completed successfully with either no or minimal fiber clotting. D-dimer was lower in the argatroban group than in the PAN group; TAT and aPTT values were similar in the two groups, which suggests better anticoagulation and a similar influence on the coagulation system. CONCLUSION:HD with the argatroban dialyzer is feasible, safe and simple, and could be used in patients at high risk of bleeding.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Zhang Y,Ning J,Veeraragoo P,Li Y,Dai Sdoi
10.1159/000336094subject
Has Abstractpub_date
2012-01-01 00:00:00pages
300-6issue
4eissn
0253-5068issn
1421-9735pii
000336094journal_volume
33pub_type
杂志文章abstract::Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000109235
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 评论,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000096390
更新日期:2007-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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doi:10.1159/000169976
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000350613
更新日期:2013-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
doi:10.1159/000104868
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000167011
更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1159/000437410
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00