Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant.

Abstract:

BACKGROUND/AIMS:Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. METHODS:We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane and verified its anticoagulation efficiency and its influence on coagulation markers such as activated partial thromboplastin time (aPTT), D-dimer and thrombin-antithrombin complex (TAT) in an animal HD model. RESULTS:All HD sessions with the argatroban dialyzer were completed successfully with either no or minimal fiber clotting. D-dimer was lower in the argatroban group than in the PAN group; TAT and aPTT values were similar in the two groups, which suggests better anticoagulation and a similar influence on the coagulation system. CONCLUSION:HD with the argatroban dialyzer is feasible, safe and simple, and could be used in patients at high risk of bleeding.

journal_name

Blood Purif

journal_title

Blood purification

authors

Zhang Y,Ning J,Veeraragoo P,Li Y,Dai S

doi

10.1159/000336094

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

300-6

issue

4

eissn

0253-5068

issn

1421-9735

pii

000336094

journal_volume

33

pub_type

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