Abstract:
:Plasma exchange (PE) is an effective therapeutic method used in patients with myasthenia gravis (MG) refractory to common therapy and/or with life-threatening respiratory complications. Except for acetylcholine receptor antibodies (AChRAbs), some other inflammatory mediators possibly activated in MG may also be removed during PE. Serum levels of soluble adhesion molecules (sICAM-1 and sVCAM-1), IL-6 and soluble receptors for IL-2 (sIL-2R), IL-6 (sIL-6R) and TNF alpha (sTNF-R II) were measured in 20 MG patients assigned to treatment with PE. On the basis of the serum levels of AChRAb the patients were subdivided into 2 groups (8 patients with low AChRAb, 12 patients with high AChRAb). Soluble adhesion molecules and cytokines were measured before the first and last PE, at the end of the first PE and in the samples of plasma filtrate obtained during the first PE. Before the first PE patients with MG had higher serum levels of sICAM-1, sVCAM-1, sIL-2R and sTNF-R II than controls. Both after the first PE and during the course of PE, a substantial decrease in serum levels of AChRAb, sICAM-1 and sVCAM-1 was recorded. However, serum levels of sIL-2R and sTNF-R II were not significantly influenced by either a single treatment or during the course of PE. There were high levels of AChRAb, soluble adhesion molecules and soluble cytokine receptors in plasma filtrates too. Patients with high circulating AChRAb had higher serum levels of sICAM-1 and sVCAM-1 than patients with low AChRAb. Increased serum levels of soluble adhesion molecules and soluble cytokine receptors in patients with MG suggest some systemic activation of the immune response which is more pronounced in patients with high circulating AChRAb. PE led to the decrease in serum AChRAb and soluble adhesion molecules due to their effective filtration but, on the other hand, serum levels of soluble cytokine receptors were not influenced by PE, in spite of their effective filtration which is probably counteracted by their increased production, possibly stimulated by the contact of the blood with the synthetic membrane.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Tesar V,Jelínková E,Jirsa M Jr,Bakosová M,Pitha P,Chábová Vdoi
10.1159/000014434subject
Has Abstractpub_date
2000-01-01 00:00:00pages
115-20issue
2eissn
0253-5068issn
1421-9735pii
14434journal_volume
18pub_type
杂志文章abstract::Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,评审
doi:10.1159/000169557
更新日期:1988-01-01 00:00:00
abstract::Activation of polymorphonuclear leukocytes with subsequent production of reactive oxygen metabolites has been reported to occur during hemodialysis related to a membrane bioincompatibility. We used an experimental dialysis model to evaluate, by chemiluminescence, the production of reactive oxygen metabolites and, by C...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169604
更新日期:1989-01-01 00:00:00
abstract::The principles and use of plasmapheresis are often little understood by intensivists. We propose to review the principles, the main indications, and the methods of using this technique. ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000510983
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND/AIMS:There is a clear association between one allele of the interleukin-1 receptor-antagonist gene (IL-1RN) and inflammatory diseases in which IL-1 is implicated. We evaluated patient survival and technique survival of peritoneal dialysis (PD) patients, while analyzing independent risk factors, in a PD progr...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000088988
更新日期:2005-01-01 00:00:00
abstract::Doubt has remained as to whether or not the K/DOQI recommended targets for adequacy of dialysis for peritoneal dialysis patients is appropriate (weekly Kt/V 2 + creatinine clearance 50-60 l/1.73 m(2)). The ADEMEX trial can be interpreted as indicating that lower targets might be acceptable. The HEMO trial, not yet pub...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000067869
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Despite the progression of dialysis techniques, the mortality of hemodialysis (HD) patients is still high in China. Here, a retrospective study was performed to investigate the neglected risk factors of all-cause mortality during maintenance HD (MHD). METHODS:We investigated 117 MHD patients who died betwe...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000497269
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine adsorption and transmembrane clearances (CLTM) of rezafungin, a novel long-acting echinocandin, in continuous venovenous hemofiltration (CVVH). METHODS:A validated ex vivo bovine blood CVVH model using polysulfone and AN69 hemodiafilters was used to evaluate urea and rezafungin CLTM at 3 d...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000489212
更新日期:2018-01-01 00:00:00
abstract::Many organic solutes accumulate in end-stage renal disease (ESRD) and some are poorly removed with urea-based prescriptions for hemodialysis. However, their toxicities have been difficult to assess. We have employed an animal model, the zebrafish embryo, to test the toxicity of uremic serum compared to control. Serum ...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000348456
更新日期:2013-01-01 00:00:00
abstract:AIMS:To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis. METHODS:A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful kid...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000157373
更新日期:2008-01-01 00:00:00
abstract::We conducted a prospective randomized controlled study to confirm our earlier observation that prolonged subcutaneous implantation of peritoneal catheter reduced peritonitis rate when compared to retrospective data from patients with catheters placed by conventional access technique. A total of 60 patients were random...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000014331
更新日期:1998-01-01 00:00:00
abstract::There is a wide variability in the utilization of peritoneal dialysis throughout Europe that cannot be explained by differences in medical factors alone. Over the last years, the utilization of peritoneal dialysis has even changed in individual countries. The main factors of this variation are not medical, but rather ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000089446
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:We estimated the flow of endotoxins (ET) from dialysates into the blood of patients on hemodialysis (HD) using limulus amebocyte lysate (LAL) assays and endotoxin activity (EA) determined by neutrophil respiratory burst activity. METHODS:A cross-sectional study compared groups given ultrapure bicarbonate (n...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000322622
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:Hyperhomocysteinemia (HH), a known risk factor for vascular diseases, is a frequent condition in hemodialysis (HD) patients. HH induces an oxidant stress to the vascular endothelium, causing a failure of vasodilation and an impairment of the antithrombotic properties. Vitamins B(6), B(12) and folic acid are ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000014416
更新日期:2000-01-01 00:00:00
abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000169968
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:Japan's aging population has prominent epidemiological and patient characteristics. The number of hemodialysis patients aged ≥70 years is increasing. Age-adjusted mortality is improving, but some cause-specific mortalities remain unchanged, including infectious disease and malignancy, requiring combativ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000496660
更新日期:2019-01-01 00:00:00
abstract::During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free bio...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000320133
更新日期:2010-01-01 00:00:00
abstract::In the last years, publications have questioned the classical dose of 35 ml/kg, but are those studies strong enough in terms of scientific power in order to change our practice? We will try to settle some recommendations for clinicians. Manipulation of dose, porosity, and combinations have yielded promising findings. ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000227282
更新日期:2009-01-01 00:00:00
abstract::In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoc...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000316684
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Glycated hemoglobin is used to assess diabetic control although its accuracy in dialysis has been questioned. How does it compare to the Continuous Glucose Monitoring System (CGMS) in peritoneal dialysis (PD) patients? METHODS:We conducted a retrospective analysis of 60 insulin-treated diabetic patients o...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000439242
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000338923
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS:Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RES...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000487223
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Plastic cannulas have been used to cannulate arteriovenous fistulas (AVFs) for hemodialysis (HD) in Japan for many years. However, the effect of early cannulation with plastic cannulas on AVF patency is not known. OBJECTIVE:We analyzed the relationship between first cannulation time (FCT) and patency rate...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000503678
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Recent advances in nanotechnology have made it possible to mass-produce ultrathin silicon membranes with pore sizes in the range of nanometers. In this study, we investigate the possibility of employing ultrathin nanoporous silicon membranes with pore diameters of 5 and 20 nm for dialysis of human whole...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000350613
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000230812
更新日期:2009-01-01 00:00:00
abstract::At present the treatment of hepatitis C virus infection (HCV) has improved because of combined treatment with interferon (IFN) and ribavirin. The association of these two drugs has obtained a positive response in 40-50% of naive patients treated. Patients with relapse after monotherapy with IFN also show positive resp...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000046996
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Intravenous iron infusion is the accepted way of supplementation of that compound in uremic patients. The aim of the study was to evaluate whether this treatment affects intraperitoneal homeostasis in patients on peritoneal dialysis. METHODS:Blood and peritoneal dialysate samples were collected from 10...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000210038
更新日期:2009-01-01 00:00:00
abstract::A review is given of the conditions associated with peritoneal membrane failure, and the possible causes. Ultrafiltration failure is the most important manifestation. It is mostly associated with high transport rates of low molecular weight solutes suggesting the presence of a large vascular surface area. Enlargement ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000065202
更新日期:2002-01-01 00:00:00
abstract::Along with the numerous technological improvements in molecular biology, polymerase chain reaction, which permits analysis of sequences of a very small amount of biological material, enables evaluation of hemodialysis-induced gene transcription of inflammatory cytokines. Blood samples drawn from 22 hemodialysis patien...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014310
更新日期:1998-01-01 00:00:00
abstract::In hemodialysis patients, C-reactive protein (CRP), an acute-phase reactant, is a sensitive and independent marker of malnutrition, anemia, and amyloidosis. The aim of the present studies was to evaluate CRP and interleukin 6 levels in plasma samples from long-term hemodialysis patients on different extracorporeal mod...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000014405
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. METHODS:We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethyl...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000441438
更新日期:2016-01-01 00:00:00