Amino acids and keto acids in the treatment of chronic renal failure.

Abstract:

:Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect is obtained are reviewed. The potential advantages of keto acids upon amino acids, the optimal composition of the preparations used, and the best time to start treatment in chronic uremics are discussed. Projection of recent data indicate that a prolongation of renal autonomy of about 4 years instead of a spontaneous duration of 15 months until dialysis can be expected using keto acid treatment if started when plasma creatinine reaches 500 mumol/l.

journal_name

Blood Purif

journal_title

Blood purification

authors

Jungers P,Chauveau P

doi

10.1159/000169557

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

299-314

issue

5

eissn

0253-5068

issn

1421-9735

journal_volume

6

pub_type

临床试验,杂志文章,评审
  • Application of speckle-tracking echocardiography in detecting coronary artery disease in patients with maintenance hemodialysis.

    abstract:BACKGROUND:Satisfactory and noninvasive diagnostic tools for coronary artery disease (CAD) are not available in hemodialysis patients. We aimed to elucidate a reliable tool to diagnose CAD in these patients. METHODS:102 hemodialysis patients received 2D speckle-tracking echocardiography with left ventricular (LV) stra...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000323536

    authors: Liu YW,Su CT,Wang SP,Yang CS,Huang JW,Hung KY,Chen JH,Tsai WC

    更新日期:2011-01-01 00:00:00

  • The Role of Dialysis Membranes on Intradialytic Selenium Removal and on Selenium Status in Patients Receiving Renal Replacement Therapy.

    abstract:BACKGROUND/AIMS:Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. METHODS:We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethyl...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000441438

    authors: Sonikian M,Dona A,Skarakis J,Trompouki S,Miha T,Karatzas I,Spiliopoulou C

    更新日期:2016-01-01 00:00:00

  • Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration.

    abstract::During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free bio...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000320133

    authors: Borrelli S,Minutolo R,De Nicola L,Zamboli P,Iodice C,De Paola A,De Simone E,Zito B,Guastaferro P,Nigro F,Apperti V,Iulianiello G,Credendino O,Iacono G,Di Serafino A,D'Apice L,Saviano C,Sarti A,Capuano M,Genualdo R,

    更新日期:2010-01-01 00:00:00

  • Heart rate variability in peritoneal dialysis patients: what is the role of residual renal function?.

    abstract:BACKGROUND:The relationship between heart rate variability (HRV) and residual renal function (RRF) has not been elucidated previously. METHODS:In this cross-sectional study, HRV was evaluated in 71 peritoneal dialysis patients. Patients were divided into RRF decline group, RRF stable group and anuric group. RESULTS:R...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338184

    authors: Tang W,Li LX,Pei J,Wang T

    更新日期:2012-01-01 00:00:00

  • A 15-year-old girl with severe hemolytic Wilson's crisis recovered without transplantation after extracorporeal circulation with the Prometheus system.

    abstract:BACKGROUND:Wilson's disease (WD) can present in a fulminant form with hepatocellular dysfunction, hemolysis and multiorgan failure (Wilson's crisis). We present a previously healthy young woman with severe WD whose WD severity score was 13. A score >11 indicates a poor chance of survival and liver transplantation will ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000218090

    authors: Aagaard NK,Thomsen KL,Holland-Fischer P,Jørgensen SP,Ott P

    更新日期:2009-01-01 00:00:00

  • A case of McLeod syndrome with chronic renal failure.

    abstract::A 50-year-old man with the rare McLeod syndrome, associated with glomerular lesion to the end stage of chronic renal failure and death, is reported. McLeod syndrome is an X-linked recessive disorder on the basis of abnormal expression of the Kell blood group antigens and absence of erythrocyte surface Kx antigen. Most...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014353

    authors: Jeren-Strujić B,Jeren T,Thaller N,Zivković Z,Raos V

    更新日期:1998-01-01 00:00:00

  • Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion.

    abstract::In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoc...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000316684

    authors: Testa A,Dejoie T,Lecarrer D,Wratten M,Sereni L,Renaux JL

    更新日期:2010-01-01 00:00:00

  • Con-Current versus Counter-Current Dialysate Flow during CVVHD. A Comparative Study for Creatinine and Urea Removal.

    abstract:BACKGROUND:Dialysate fluid connection to the membrane in continuous dialysis may affect solute clearance. Although circuit connections are routinely made counter-current to blood flow in intermittent dialysis, no study has assessed the effect of this dialysate fluid flow direction on removal of small solutes creatinine...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000441270

    authors: Baldwin I,Baldwin M,Fealy N,Neri M,Garzotto F,Kim JC,Giuliani A,Basso F,Nalesso F,Brendolan A,Ronco C

    更新日期:2016-01-01 00:00:00

  • Effects of Multidisciplinary Team Care Based on 5E's Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial.

    abstract:BACKGROUND:The number of patients with peritoneal dialysis (PD) in China has been increasing year after year, but there are still some challenge in the management of PD patients, and the efficient and effective method has yet to be developed. Multidisciplinary team (MDT) is to create a standardized, individualized, and...

    journal_title:Blood purification

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000496823

    authors: Luo Y,Huang Y,Chen X,Meng G,Zhang Y

    更新日期:2019-01-01 00:00:00

  • Methylation status of immune response genes promoters in cell-free DNA differs in hemodialyzed patients with diabetic nephropathy according to the intensity of anemia therapy.

    abstract:BACKGROUND:Anemia is a major complication of end-stage renal disease. Hemodialysis itself is regarded as a stimulus activating inflammation. Pro-inflammatory cytokines are able to suppress erythropoiesis. In this pilot study, we analyzed the changes in methylation status of promoters of immune response genes in cell-fr...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000356094

    authors: Korabecna M,Pazourkova E,Horinek A,Mokrejsova M,Tesar V

    更新日期:2013-01-01 00:00:00

  • Enhanced functional performance characteristics of a new polysulfone membrane for high-flux hemodialysis.

    abstract::Elimination of uremic solutes with molecular weights up to 60 kD, without significant loss of albumin is an important therapeutic goal to optimize outcomes in chronic hemodialysis patients. To characterize a newly developed polysulfone dialyzer (APS-650) a comparative analysis was performed with a highly advanced poly...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000063099

    authors: Klingel R,Ahrenholz P,Schwarting A,Röckel A

    更新日期:2002-01-01 00:00:00

  • Initiation Condition of Hemodialysis Is Independently Associated with All-Cause Mortality in Maintenance Hemodialysis Patients: A Retrospective Study.

    abstract:BACKGROUND:Despite the progression of dialysis techniques,  the mortality of hemodialysis (HD) patients is still high in China. Here, a retrospective study was performed to investigate the neglected risk factors of all-cause mortality during maintenance HD (MHD). METHODS:We investigated 117 MHD patients who died betwe...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000497269

    authors: Wang C,Yang Y,Yuan F,Li HQ,He LY,Liu D,Liu YX,Zhou A,Chen X,Liu FY,Peng YM,Liu H

    更新日期:2019-01-01 00:00:00

  • Anticoagulation of diethyl citrate and its comparison with sodium citrate in an animal model.

    abstract:AIMS:To improve the side effects caused by sodium citrate (Na(3)Cit), the anticoagulant effects of diethyl citrate (Et(2)Cit) were investigated. METHODS:The in vitro anticoagulant effects and dissociation capacity of the chelate of Et(2)Cit with calcium ions were compared with those of Na(3)Cit in rabbits. RESULTS:Th...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000330891

    authors: Chen Z,Chen B,Yao XQ,Gui BS,Ou Y,Ouyang JM

    更新日期:2012-01-01 00:00:00

  • Impact of acute renal failure on the relationship between N-terminal pro-B-type natriuretic peptide and hemodynamic parameters.

    abstract:BACKGROUND:We studied the influence of acute renal failure (ARF) on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hemodynamic parameters. METHODS:The echocardiographic parameters and NT-proBNP levels were compared between 26 mechanically ventilated patients with ARF requiring conti...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322259

    authors: Balik M,Jabor A,Otahal M,Waldauf P,Pavlisova M

    更新日期:2011-01-01 00:00:00

  • Pulsatile flow improves renal function in high-risk cardiac operations.

    abstract::The effects of pulsatile perfusion on microcirculation and renal function in high-risk patients were evaluated in this study. Pulsatile roller pumps with a pulsatile control module and membrane oxygenator were used in a clinical setting. 40 patients undergoing elective cardiac surgery with a high risk of either having...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000085174

    authors: Kocakulak M,Aşkin G,Kuçukaksu S,Tarcan O,Pişkin E

    更新日期:2005-01-01 00:00:00

  • The Rise of Expanded Hemodialysis.

    abstract::The low water permeability feature of original cellulosic membranes was considered an advantage in the absence of dialysis equipment that are capable of controlling water removal. The advent of ultrafiltration control systems led to the development and use of high-flux (HF) membranes that allowed improved middle molec...

    journal_title:Blood purification

    pub_type: 社论

    doi:10.1159/000476012

    authors: Ronco C

    更新日期:2017-01-01 00:00:00

  • Defective interleukin-10 synthesis by peripheral blood mononuclear cells among hemodialysis patients.

    abstract:BACKGROUND:Interleukin-10 (IL-10), a potent regulatory monokine produced by activated mononuclear cells, provides an efficient autocrine mechanism for controlling proinflammatory cytokine synthesis. We hypothesized that defective synthesis of IL-10 could contribute to the inflammatory state in hemodialysis (HD) patient...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000066958

    authors: Perianayagam MC,Jaber BL,Guo D,King AJ,Pereira BJ,Balakrishnan VS

    更新日期:2002-01-01 00:00:00

  • End-stage renal failure patients requiring renal replacement therapy in the intensive care unit: incidence, clinical features, and outcome.

    abstract:AIMS:To study incidence, clinical features, and outcome of critically ill patients with end-stage renal failure (ESRF) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) and to test the validity of severity scoring systems for these patients. METHODS:Data for ESRF patients treated with RRT were...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000069156

    authors: Uchino S,Morimatsu H,Bellomo R,Silvester W,Cole L

    更新日期:2003-01-01 00:00:00

  • Homocysteine as a cardiovascular risk factor.

    abstract:UNLABELLED:Hyperhomocysteinemia (HH), a known risk factor for vascular diseases, is a frequent condition in hemodialysis (HD) patients. HH induces an oxidant stress to the vascular endothelium, causing a failure of vasodilation and an impairment of the antithrombotic properties. Vitamins B(6), B(12) and folic acid are ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000014416

    authors: Biasioli S,Schiavon R

    更新日期:2000-01-01 00:00:00

  • Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

    abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000493178

    authors: Leypoldt JK,Vonesh EF

    更新日期:2019-01-01 00:00:00

  • Chronic kidney disease stages are appropriate at all ages.

    abstract::Chronic kidney disease (CKD) is associated with multiple detrimental consequences to the cardiovascular and musculoskeletal systems. The effects of CKD are even more significant when they begin in childhood as they affect growth and (neuro-) development as well. The division into stages of CKD serves as a guideline fo...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000321850

    authors: Goilav B,Kaskel FJ

    更新日期:2011-01-01 00:00:00

  • Biocompatibility of hemodialysis membranes: a study in healthy subjects.

    abstract::The effect of blood-membrane interaction on several biocompatibility parameters has been investigated. Four groups of healthy subjects underwent sham hemodialysis, i.e. the establishment of blood-dialysis membrane contact, but without circulating dialysate, using cellulose-based membranes (regenerated cellulose and ce...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170153

    authors: Gutierrez A,Alvestrand A,Bergström J,Beving H,Lantz B,Henderson LW

    更新日期:1994-01-01 00:00:00

  • Non-alcoholic fatty liver disease proven by transient elastography in hemodialysis patients: is it a new risk factor for adverse cardiovascular events?

    abstract:BACKGROUND/AIMS:Cardiovascular diseases (CVD) are the leading cause of mortality in hemodialysis (HD) patients. Recently, non-alcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. Our aim was to analyze the incidence of NAFLD in HD patients by u...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000360270

    authors: Mikolasevic I,Orlic L,Milic S,Zaputovic L,Lukenda V,Racki S

    更新日期:2014-01-01 00:00:00

  • Angiotensin Converting Enzyme Inhibitor Dialyzability and Outcomes in Older Patients Receiving Hemodialysis.

    abstract:BACKGROUND/AIMS:Some angiotensin converting enzyme (ACE) inhibitors are efficiently removed from circulation by hemodialysis ('high dialyzability'), whereas others are not ('low dialyzability'). In patients receiving hemodialysis, this may influence the effectiveness of ACE inhibitors. METHODS:Using linked healthcare ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000438821

    authors: Weir MA,Fleet JL,Dixon SN,Jain AK,Oliver M,Wald R,McIntyre C,Garg AX

    更新日期:2015-01-01 00:00:00

  • Therapeutic Plasma Exchange in Neonates and Infants: Successful Use of a Miniaturized Machine.

    abstract::Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinem...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000470827

    authors: Vidal E,Garzotto F,Parolin M,Manenti C,Zanin A,Bellettato M,Remuzzi G,Goldstein SL,Murer L,Ronco C

    更新日期:2017-01-01 00:00:00

  • A zebrafish model for uremic toxicity: role of the complement pathway.

    abstract::Many organic solutes accumulate in end-stage renal disease (ESRD) and some are poorly removed with urea-based prescriptions for hemodialysis. However, their toxicities have been difficult to assess. We have employed an animal model, the zebrafish embryo, to test the toxicity of uremic serum compared to control. Serum ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000348456

    authors: Berman N,Lectura M,Thurman J,Reinecke J,Raff AC,Melamed ML,Reinecke J,Quan Z,Evans T,Meyer TW,Hostetter TH

    更新日期:2013-01-01 00:00:00

  • Practice guidelines do improve patient outcomes: association or causation?

    abstract::Guidelines have been developed in nephrology and medicine developed to assist practitioners and patients in making decisions about healthcare for specific clinical circumstances. There has been a proliferation of guidelines over the last decade in all areas of medicine, including nephrology. Many of the nephrology gui...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000110568

    authors: Levin A

    更新日期:2008-01-01 00:00:00

  • Pathogenesis and management of upper-extremity ischemia following angioaccess surgery.

    abstract::Thirty-four patients with end-stage renal disease requiring hemodialysis developed over the course of 7 years (1987-1994) severe ischemia in the extremity carrying the angioaccess secondary to arterial 'steal'. Seven of these patients were treated with access ligation, 4 with banding reducing the flow through the acce...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170286

    authors: Haimov M,Schanzer H,Skladani M

    更新日期:1996-01-01 00:00:00

  • Ischemic Heart Disease in Patients with End-Stage Kidney Disease.

    abstract:BACKGROUND:It was recently reported that the severity of coronary and carotid atherosclerosis in patients with end-stage kidney disease (ESKD) has improved over the last two decades. However, the frequency of coronary artery events observed at the initiation of dialysis remains high. SUMMARY:Recently, 5 different clin...

    journal_title:Blood purification

    pub_type: 评论,杂志文章

    doi:10.1159/000441582

    authors: Tanaka Y,Joki N,Hase H

    更新日期:2015-01-01 00:00:00

  • Effect of Early Cannulation with Plastic Cannula on Arteriovenous Fistula Patency in Hemodialysis Patients.

    abstract:INTRODUCTION:Plastic cannulas have been used to cannulate arteriovenous fistulas (AVFs) for hemodialysis (HD) in Japan for many years. However, the effect of early cannulation with plastic cannulas on AVF patency is not known. OBJECTIVE:We analyzed the relationship between first cannulation time (FCT) and patency rate...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000503678

    authors: Shi K,Jiang H,Wakabayashi M

    更新日期:2020-01-01 00:00:00