Haemolipodialysis.

Abstract:

:Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologies associated with chronic renal failure. Haemolipodialysis (HLD) is a new haemodialytic technique aimed at reducing oxidant stress and removing hydrophobic or protein bound toxins. The technique uses dialysate containing ascorbic acid (vitamin C) and polyunsaturated unilamellar liposomes containing alpha-tocopherol (vitamin E). The liposomes interact with blood components at the haemodialysis membrane without passage through the membrane. Vitamin C and vitamin E are added to the system to protect the cell and plasma components from reactive oxygen species produced from activated inflammatory cells. This technique may provide a new approach in preventing free radical-associated pathologies in chronic haemodialysis patients.

journal_name

Blood Purif

journal_title

Blood purification

authors

Wratten ML,Navino C,Tetta C,Verzetti G

doi

10.1159/000014384

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

127-33

issue

2-3

eissn

0253-5068

issn

1421-9735

pii

14384

journal_volume

17

pub_type

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