Natural killer cell dysfunction in uremia: the role of oxidative stress and the effects of dialysis.

abstract：:Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated mu...

journal_title：Blood purification

authors： Ronco C,Bagshaw SM,Bellomo R,Clark WR,Husain-Syed F,Kellum JA,Ricci Z,Rimmelé T,Reis T,Ostermann M

更新日期：2021-01-01 00:00:00

abstract：:This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory compromise in states of shock and renal compromise is discussed....

journal_title：Blood purification

authors： Guven G,Hilty MP,Ince C

更新日期：2020-01-01 00:00:00

abstract：:Pathophysiological aspects of plasma volume preservation and cardiovascular reactivity are reviewed, comparing combined ultrafiltration-hemodialysis with isolated ultrafiltration and hemofiltration. The role of different factors in the disparity in cardiovascular reactivity between these treatments is discussed. ...

journal_title：Blood purification

authors： Hendrikus W,van Kuijk M,Leunissen KM

更新日期：1996-01-01 00:00:00

abstract：:A new plate dialyzer, Gambro PRO-3, with a polycarbonate-polyether membrane (Gambrane) was tested. The membrane thickness is 16 micron and the dialyzer surface area 0.77 m2. 11 regular hemodialysis patients who were treated 3 times per week were studied and 32 dialyses were performed. Clearances of urea, creatinine, u...

journal_title：Blood purification

authors： Wehle B,Oja-Pettersson K,Schyllert B,Diehl U,Bergström J

更新日期：1986-01-01 00:00:00

abstract：:Evidence that protein restriction retards the progression of chronic renal failure in man is mostly derived from anecdotic data and retrospective studies with inappropriate controls and inferior methodology for evaluating renal function. Data from a prospective randomized study in Stockholm demonstrate that more frequ...

journal_title：Blood purification

authors： Bergström J,Alvestrand A,Bucht H,Gutierrez A

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIMS:Increasing evidence suggests that clinical signs of periodontal disease are independently associated with renal impairment. However, no studies have examined the possible linkage of kidney disease with serum antibody to oral pathogens. METHODS:The periodontal disease status was assessed in an older com...

journal_title：Blood purification

authors： Kshirsagar AV,Offenbacher S,Moss KL,Barros SP,Beck JD

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:We explored whether biocompatible dialyzer membranes modulate the inflammatory response during blood contact in patients with systemic inflammation. METHODS:15 patients with end-stage renal disease and systemic inflammation (mean serum C-reactive protein 86 +/- 4 mg/l) were randomly treated with Cuprophan (...

journal_title：Blood purification

authors： Gueler F,Gwinner W,Schiborr C,Martin M,Klos A,Kirsch T,Fiebeler A,Haller H,Fliser D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors...

journal_title：Blood purification

authors： Snaedal S,Qureshi AR,Carrero JJ,Heimbürger O,Stenvinkel P,Bárány P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Of 5 clinical trials testing dose response of continuous renal replacement therapy (CRRT) in acute kidney injury, 2 showed a benefit, 2 showed none, and 1 appeared equivocal. However, blood-membrane interactions may dominate macromolecule transport in continuous venovenous hemodiafiltration, reducing the imp...

journal_title：Blood purification

authors： Hofmann CL,Fissell WH

更新日期：2010-01-01 00:00:00

abstract：:Kidney transplantation (KT) is considered an optimal treatment strategy for end-stage renal disease. But human leukocyte antigen-sensitized, ABO-incompatible and antibody-mediated rejection might be the alarming hurdles in KT. Therapeutic plasma exchange is the mainstay of the antibody reduction therapy for reducing a...

journal_title：Blood purification

authors： Xie P,Tao M,Peng K,Zhao H,Zhang K,Sheng Y,Ankawi G,Ronco C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Removal of protein-bound uremic toxins by dialysis therapy is limited. The effect of oral adsorbent AST-120 in chronic dialysis patients has rarely been investigated. METHODS:AST-120 was administered 6.0 g/day for 3 months in 69 chronic dialysis patients. The blood concentrations of indoxyl sulfate, p-creso...

journal_title：Blood purification

authors： Lee CT,Hsu CY,Tain YL,Ng HY,Cheng BC,Yang CC,Wu CH,Chiou TT,Lee YT,Liao SC

更新日期：2014-01-01 00:00:00

abstract：:The EUPHRATES trial (Evaluating Use of Polymyxin B Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemia and Septic Shock) is the first biomarker-driven trial in sepsis. This unique trial is being run in a blinded manner, further contributing to the robustness of its design. This paper will ...

journal_title：Blood purification

authors： Foster D,Klein DJ,Guadagni G,Walker PM

更新日期：2014-01-01 00:00:00

abstract：:Renal anemia is the result of reduced erythropoietin (EPO) biosynthesis in the diseased kidney and also in part the result of a reduced life span of red blood cells (RBCs). An increase in density and a decrease in enzyme equipment (aspartate aminotransferase; GOT) of RBCs reflect cell age. In the following study, the ...

journal_title：Blood purification

authors： Hampl H,Riedel E,Wendel G,Scigalla P

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS:Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RES...

journal_title：Blood purification

authors： Kundakci Gelir G,Sengul S,Nergizoglu G,Ertürk S,Duman N,Kutlay S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Bioelectrical impedance analysis (BIA) is a promising technique to evaluate dry weight. We compared the dry weight calculated by the three BIA equations Carlo Basile (CB) , Yanna Dou (YD) and the body composition spectroscopy (BCS) with clinical evaluation in maintenance hemodialysis (MHD) patients. METHODS...

journal_title：Blood purification

authors： Jian Y,Li X,Cheng X,Chen Y,Liu L,Tao Z,Zuo L

更新日期：2014-01-01 00:00:00

abstract：:In 5 uremic patients the role of opioid peptides in dialysis-induced hypotension was investigated through the administration of naloxone. An intravenous bolus injection of 1 mg of naloxone was administered immediately before starting a routine hemodialysis session and was repeated when the patients' systolic arterial ...

journal_title：Blood purification

authors： Sturani A,Degli Esposti E,Chiarini C,Spongano M,Santoro A,Zucchelli P

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIM:The relationship between body mass index (BMI) and intradialytic hypotension (IDH) has been inconsistently reported, but no further research has investigated the correlation between body composition and IDH so far. This study aimed to determine whether the lean tissue index (LTI), fat tissue index (FTI),...

journal_title：Blood purification

authors： Tian M,Zha Y,Qie S,Lin X,Yuan J

更新日期：2020-01-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), peptides and proteins circulate at altered concentrations versus in healthy individuals. We have characterized proteome samples from 7 pooled CKD stage 5 patients not yet on dialysis and with no known co-morbidities. We also analyzed pooled plasma samples from 7 healthy a...

journal_title：Blood purification

authors： Naseeb U,Shafqat J,Jägerbrink T,Zarina S,Alvestrand A,Jörnvall H,Axelsson J

更新日期：2008-01-01 00:00:00

abstract：:The biological effect of oxygen-reactive species controlled by antioxidant mechanisms are exerted on the basis of antioxidant enzymes and substrates. In this study, the activities of antioxidant enzymes-superoxide dismutase (SOD) and glutathione peroxidase (GPx)-were determined in the erythrocytes of patients on regul...

journal_title：Blood purification

authors： Zima T,Stípek S,Crkovská J,Nĕmecek K,Pláteník J,Bártová V,Tesar V

更新日期：1996-01-01 00:00:00

abstract：:A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to und...

journal_title：Blood purification

authors： Bowry SK,Gatti E

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated. METHODS:Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose ef...

journal_title：Blood purification

authors： Zhou Y,Yin P,Li B,Li J,Huang N,Wu H,Ullah H,Yang X,Yu X

更新日期：2018-01-01 00:00:00

abstract：:Heart failure (HF) is a chronic disease process associated with significant morbidity and mortality. Hospitalizations for acute decompensation may be frequent and herald a downward trajectory for the underlying disease state and overall poor prognosis for the patient. While significant advances have been made in the r...

journal_title：Blood purification

authors： Virani SA

更新日期：2008-01-01 00:00:00

abstract：:Reprocessing of used dialyzers with chemical disinfectants is practiced commonly in the United States and in some areas of Western Europe. Concern over residual toxic or allergenic agents has encouraged the search for other practical methods to disinfect or sterilize used hemodialyzers. The use of moist heat has been ...

journal_title：Blood purification

authors： Holmes CJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Standard low-flux haemodialysis (HD) is not very efficacious, and patient morbidity and mortality rates are still very high. According to the initial study design, the MPO study reported that high-flux HD (hf-HD) showed a significant 37% relative risk reduction of mortality in patients with serum albumin ≤4 ...

journal_title：Blood purification

authors： Locatelli F,Violo L,Longhi S,Del Vecchio L

更新日期：2015-01-01 00:00:00

abstract：:A group of patients with severe anemia on standard hemodialysis were transferred to polyacrylnitrile hemodiafiltration (HDF), which was arranged in order to obtain an ultrafiltration rate (UF) higher than 100 ml/min. During HDF, despite a significant reduction of the dialysis time, all patients had a significant decre...

journal_title：Blood purification

authors： Gonella M,Pratesi G,Calabrese G,Vagelli G,Mazzotta A

更新日期：1989-01-01 00:00:00

abstract：:The evidence concerning online hemodiafiltration (HDF) includes the following: (1) the increase of removal of uremic toxin, (2) the prevention of dialysis rerated hypotension, (3) the recovery of survival, and (4) the recovery of dialysis related uncertain symptoms. Although clinical evidence has been noted, the hypot...

journal_title：Blood purification

authors： Kawanishi H

更新日期：2018-01-01 00:00:00

abstract：:Malnutrition, which is common in maintenance hemodialysis (HD) patients, is strongly associated with increased morbidity and mortality. Protein requirements in HD patients are increased twice or more compared to those of healthy subjects. Underdialysis leads to anorexia with low protein and energy intake in relation t...

journal_title：Blood purification

authors： Bergström J

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Omni® (B. Braun, Germany) is a new-generation, continuous renal replacement therapy (CRRT) machine designed to improve user interface, minimize downtime and optimize renal dose delivery. It was never tested in humans. METHODS:We used Omni® to provide CRRT in 10 critically ill patients. We collected therapy ...

journal_title：Blood purification

authors： Schläpfer P,Durovray JD,Plouhinec V,Chiappa C,Bellomo R,Schneider A

更新日期：2017-01-01 00:00:00

abstract：AIMS:The aim of the study was to clarify the relationship between serum ferritin and infectious risks. METHODS:We evaluated all hospital admissions due to infections, clinical biomarkers and nutrition status in 129 incident Japanese dialysis patients during a median follow-up of 38 months. RESULTS:Kaplan-Meier analys...

journal_title：Blood purification

authors： Kato S,Lindholm B,Yuzawa Y,Tsuruta Y,Nakauchi K,Yasuda K,Sugiura S,Morozumi K,Tsuboi N,Maruyama S

更新日期：2016-01-01 00:00:00

abstract：:In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoc...

journal_title：Blood purification

authors： Testa A,Dejoie T,Lecarrer D,Wratten M,Sereni L,Renaux JL

更新日期：2010-01-01 00:00:00