Effect of Sedative-Hypnotic Medicines on Mortality in Peritoneal Dialysis Patients with Sleep Disorders: A Retrospective Cohort Study.

Abstract:

BACKGROUND:Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated. METHODS:Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose effect on mortality was evaluated by Cox proportional hazards models. RESULTS:A total of 146 CAPD patients with sleep disorders were recruited, of which 46 patients (31.5%) used either benzodiazepines or zolpidem. Sedative-hypnotic medication was more frequently used by older patients and those with longer duration of CAPD therapy and there was no significant association between sedative-hypnotic medicines and all-cause mortality after adjusting for age, gender, diabetes, cardiovascular disease, and duration of CAPD. CONCLUSION:Sedative-hypnotic medication was more often used by older patients and patients with a longer duration of CAPD. There was no association between these agents and all-cause mortality in CAPD patients with sleep disorders.

journal_name

Blood Purif

journal_title

Blood purification

authors

Zhou Y,Yin P,Li B,Li J,Huang N,Wu H,Ullah H,Yang X,Yu X

doi

10.1159/000484922

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

95-101

issue

1-3

eissn

0253-5068

issn

1421-9735

pii

000484922

journal_volume

45

pub_type

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