Non-alcoholic fatty liver disease proven by transient elastography in hemodialysis patients: is it a new risk factor for adverse cardiovascular events?

Abstract:

BACKGROUND/AIMS:Cardiovascular diseases (CVD) are the leading cause of mortality in hemodialysis (HD) patients. Recently, non-alcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. Our aim was to analyze the incidence of NAFLD in HD patients by using transient elastography and to analyze whether the presence of NAFLD is associated with a higher CVD risk in HD patients. METHODS:The subjects were 72 HD patients and 50 sex- and age-matched controls. RESULTS:NAFLD was found in 52.8% of HD patients. HD patients with NAFLD showed more carotid atherosclerosis and more adverse CVD events than HD patients without NAFLD and control subjects. CONCLUSION:We showed for the first time that HD patients have a high prevalence of NAFLD. HD patients with NAFLD show an advanced carotid atherosclerosis. Detection of NAFLD by transient elastography should alert to the existence of an increased cardiovascular risk in HD patients.

journal_name

Blood Purif

journal_title

Blood purification

authors

Mikolasevic I,Orlic L,Milic S,Zaputovic L,Lukenda V,Racki S

doi

10.1159/000360270

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

259-65

issue

4

eissn

0253-5068

issn

1421-9735

pii

000360270

journal_volume

37

pub_type

杂志文章
  • End-stage renal failure patients requiring renal replacement therapy in the intensive care unit: incidence, clinical features, and outcome.

    abstract:AIMS:To study incidence, clinical features, and outcome of critically ill patients with end-stage renal failure (ESRF) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) and to test the validity of severity scoring systems for these patients. METHODS:Data for ESRF patients treated with RRT were...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000069156

    authors: Uchino S,Morimatsu H,Bellomo R,Silvester W,Cole L

    更新日期:2003-01-01 00:00:00

  • Dialyzer reprocessing using heat. Scientific and technical considerations.

    abstract::Reprocessing of used dialyzers with chemical disinfectants is practiced commonly in the United States and in some areas of Western Europe. Concern over residual toxic or allergenic agents has encouraged the search for other practical methods to disinfect or sterilize used hemodialyzers. The use of moist heat has been ...

    journal_title:Blood purification

    pub_type:

    doi:10.1159/000170132

    authors: Holmes CJ

    更新日期:1993-01-01 00:00:00

  • Arteriovenous hemodiafiltration associated with continuous arteriovenous hemofiltration: a combined therapy for acute renal failure in the hypercatabolic patient.

    abstract::To increase the efficiency of continuous arteriovenous hemofiltration (CAVH) in cases of severe catabolism, we used a modified CAVH treatment, called arteriovenous hemodiafiltration (AVHDF), in 4 patients. The transport of solutes was increased by providing the infusion of a counter current flow of urea-free solutions...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169454

    authors: Ronco C,Brendolan A,Bragantini L,Chiaramonte S,Fabris A,Feriani M,Dell'Aquila R,Milan M,La Greca G

    更新日期:1987-01-01 00:00:00

  • Risk Factors of Central Venous Catheter-Related Bloodstream Infection for Continuous Renal Replacement Therapy in Kidney Intensive Care Unit Patients.

    abstract:BACKGROUND:The incidence of central venous catheter-related bloodstream infection (CRBSI) for continuous renal replacement therapy (CRRT) in kidney intensive care unit (ICU) patients is worthy of particular attention and recently, we analyzed clinical characteristics and risk factors of CRBSI for CRRT in our kidney ICU...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000495024

    authors: Cheng S,Xu S,Guo J,He Q,Li A,Huang L,Liu Z,Li S

    更新日期:2019-01-01 00:00:00

  • Long-term on-line hemodiafiltration reduces predialysis beta-2-microglobulin levels in chronic hemodialysis patients.

    abstract:BACKGROUND:Hemodiafiltration (HDF) is effective in delaying the surgical need for carpal tunnel syndrome in chronic hemodialysis patients, however, predialysis beta(2)-microglobulin levels were not reduced in most short-term studies. The aim of this study was to assess the effect of long-term and differing frequencies ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000046958

    authors: Lin CL,Yang CW,Chiang CC,Chang CT,Huang CC

    更新日期:2001-01-01 00:00:00

  • Amino acids and keto acids in the treatment of chronic renal failure.

    abstract::Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,评审

    doi:10.1159/000169557

    authors: Jungers P,Chauveau P

    更新日期:1988-01-01 00:00:00

  • Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients.

    abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000230812

    authors: Murakami K,Nakanishi Y,Wakamatsu K,Yamamoto K,Kohriyama N,Hasegawa M,Tomita M,Nabeshima K,Hiki Y,Asano S,Kawashima S,Ito Y,Fujita Y,Asada H,Nakai S,Sugiyama S,Ito S

    更新日期:2009-01-01 00:00:00

  • Application of speckle-tracking echocardiography in detecting coronary artery disease in patients with maintenance hemodialysis.

    abstract:BACKGROUND:Satisfactory and noninvasive diagnostic tools for coronary artery disease (CAD) are not available in hemodialysis patients. We aimed to elucidate a reliable tool to diagnose CAD in these patients. METHODS:102 hemodialysis patients received 2D speckle-tracking echocardiography with left ventricular (LV) stra...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000323536

    authors: Liu YW,Su CT,Wang SP,Yang CS,Huang JW,Hung KY,Chen JH,Tsai WC

    更新日期:2011-01-01 00:00:00

  • Reduction of free immunoglobulin light chains using adsorption properties of hemodiafiltration with endogenous reinfusion.

    abstract::In this work we investigated the acute effects of hemodiafiltration with endogenous reinfusion (HFR therapy) on the removal of free immunoglobulin light chains (FIgLCs), which may be considered members of the family of uremic toxins. In two groups of patients - group 1 (polyclonal FIgLCs production) and group 2 (monoc...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000316684

    authors: Testa A,Dejoie T,Lecarrer D,Wratten M,Sereni L,Renaux JL

    更新日期:2010-01-01 00:00:00

  • Improvements in technology: a path to safer and more effective hemodialysis.

    abstract::Effective dialysis therapy is now understood to encompass both small and large solute removal, using approaches that minimize intradialytic symptoms and maximize patient safety. Achieving the goal of providing effective dialysis for an expanding population of patients with increasingly complex medical problems at a ti...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000167001

    authors: Ward RA,Ronco C

    更新日期:2009-01-01 00:00:00

  • Clinical investigation of the new dialyzer Gambro PRO-3.

    abstract::A new plate dialyzer, Gambro PRO-3, with a polycarbonate-polyether membrane (Gambrane) was tested. The membrane thickness is 16 micron and the dialyzer surface area 0.77 m2. 11 regular hemodialysis patients who were treated 3 times per week were studied and 32 dialyses were performed. Clearances of urea, creatinine, u...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169426

    authors: Wehle B,Oja-Pettersson K,Schyllert B,Diehl U,Bergström J

    更新日期:1986-01-01 00:00:00

  • Natural killer cell dysfunction in uremia: the role of oxidative stress and the effects of dialysis.

    abstract::Immune deficiency is one of the numerous consequences of chronic renal failure. We can hypothesize that an abnormal natural killer (NK) cell response is present in patients with end-stage renal disease (ESRD). To characterize the immune defect in ESRD patients, we performed a NK cell subset analysis in 66 patients wit...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000350839

    authors: Peraldi MN,Berrou J,Métivier F,Toubert A

    更新日期:2013-01-01 00:00:00

  • Current Evidence in Haemodiafiltration.

    abstract:BACKGROUND:Standard low-flux haemodialysis (HD) is not very efficacious, and patient morbidity and mortality rates are still very high. According to the initial study design, the MPO study reported that high-flux HD (hf-HD) showed a significant 37% relative risk reduction of mortality in patients with serum albumin ≤4 ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000437410

    authors: Locatelli F,Violo L,Longhi S,Del Vecchio L

    更新日期:2015-01-01 00:00:00

  • Clinical outcome of patients with Wegener's granulomatosis treated with plasma exchange.

    abstract::We report the clinical course of 29 patients with Wegener's granulomatosis (WG) treated with plasma exchange (PE) in Norway in the period from 1988 to 1999. Median follow-up was 41.5 months. The mean number of exchanges was 8.5 +/- 5.8 (range 2-32). Median serum creatinine concentration was 400 micromol/l (range 90-1,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000047004

    authors: Aasarød K,Iversen BM,Hammerstrøm J,Bostad L,Jørstad S

    更新日期:2002-01-01 00:00:00

  • Erythropoietin-induced changes in protein nutrition: quantitative assessment by urea kinetic modeling analysis.

    abstract::To evaluate objectively the effects of recombinant human erythropoietin (rHuEPO) administration on nutritional status in stable dialyzed patients, we used urea kinetic modeling (UKM) analysis and dietary protein intake evaluation by dietary assessment. Fifteen patients (9 females, 6 males; mean age 46.9 +/- 15.6 years...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169982

    authors: Canaud B,Bouloux C,Rivory JP,Taib J,Garred LJ,Florence P,Mion C

    更新日期:1990-01-01 00:00:00

  • Improvement of anemia in patients on chronic dialysis treated by hemodiafiltration.

    abstract::A group of patients with severe anemia on standard hemodialysis were transferred to polyacrylnitrile hemodiafiltration (HDF), which was arranged in order to obtain an ultrafiltration rate (UF) higher than 100 ml/min. During HDF, despite a significant reduction of the dialysis time, all patients had a significant decre...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169591

    authors: Gonella M,Pratesi G,Calabrese G,Vagelli G,Mazzotta A

    更新日期:1989-01-01 00:00:00

  • A 15-year-old girl with severe hemolytic Wilson's crisis recovered without transplantation after extracorporeal circulation with the Prometheus system.

    abstract:BACKGROUND:Wilson's disease (WD) can present in a fulminant form with hepatocellular dysfunction, hemolysis and multiorgan failure (Wilson's crisis). We present a previously healthy young woman with severe WD whose WD severity score was 13. A score >11 indicates a poor chance of survival and liver transplantation will ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000218090

    authors: Aagaard NK,Thomsen KL,Holland-Fischer P,Jørgensen SP,Ott P

    更新日期:2009-01-01 00:00:00

  • Peritoneal dialysis in Europe: an analysis of its rise and fall.

    abstract::There is a wide variability in the utilization of peritoneal dialysis throughout Europe that cannot be explained by differences in medical factors alone. Over the last years, the utilization of peritoneal dialysis has even changed in individual countries. The main factors of this variation are not medical, but rather ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000089446

    authors: Lameire N,Peeters P,Vanholder R,Van Biesen W

    更新日期:2006-01-01 00:00:00

  • Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration.

    abstract::During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free bio...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000320133

    authors: Borrelli S,Minutolo R,De Nicola L,Zamboli P,Iodice C,De Paola A,De Simone E,Zito B,Guastaferro P,Nigro F,Apperti V,Iulianiello G,Credendino O,Iacono G,Di Serafino A,D'Apice L,Saviano C,Sarti A,Capuano M,Genualdo R,

    更新日期:2010-01-01 00:00:00

  • A case of McLeod syndrome with chronic renal failure.

    abstract::A 50-year-old man with the rare McLeod syndrome, associated with glomerular lesion to the end stage of chronic renal failure and death, is reported. McLeod syndrome is an X-linked recessive disorder on the basis of abnormal expression of the Kell blood group antigens and absence of erythrocyte surface Kx antigen. Most...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014353

    authors: Jeren-Strujić B,Jeren T,Thaller N,Zivković Z,Raos V

    更新日期:1998-01-01 00:00:00

  • Blood Pressure of Maintenance Hemodialysis Patients in the Dalmatian Region of Croatia: Differences between Hospital and Out-of-Hospital Dialysis Centers.

    abstract:AIMS:This study was aimed at comparing the incidence of arterial hypertension and blood pressure (BP) variance in hospital and out-of-hospital hemodialysis (HD) patients during HD sessions. METHODS:A cross-sectional study was conducted for 1 week at all the HD centers in Dalmatia, Croatia. The pre-, intra-, and post-d...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000474931

    authors: Gulin M,Klarić D,Ilić M,Radić J,Kovačić V,Šain M

    更新日期:2017-01-01 00:00:00

  • Fluid resuscitation: colloids vs. crystalloids.

    abstract::The administration of intravenous fluids is perhaps the most common treatment given in the intensive care unit. According to biologic rationale, ongoing fluid losses should be replaced to maintain fluid homeostasis and relative or absolute deficiencies in circulating blood volume should be prevented or rapidly correct...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000047015

    authors: Bellomo R

    更新日期:2002-01-01 00:00:00

  • Is There Enough Evidence to Prove That Hemodiafiltration Is Superior?

    abstract::The evidence concerning online hemodiafiltration (HDF) includes the following: (1) the increase of removal of uremic toxin, (2) the prevention of dialysis rerated hypotension, (3) the recovery of survival, and (4) the recovery of dialysis related uncertain symptoms. Although clinical evidence has been noted, the hypot...

    journal_title:Blood purification

    pub_type: 社论

    doi:10.1159/000487917

    authors: Kawanishi H

    更新日期:2018-01-01 00:00:00

  • Associations between global population health indicators and dialysis variables in the Monitoring Dialysis Outcomes (MONDO) consortium.

    abstract:BACKGROUND:The number of patients receiving renal replacement therapy (RRT) increases annually and worldwide. Differences in the RRT incidence, prevalence, and modality vary between regions and countries for reasons yet to be clarified. AIMS:Gain a better understanding of the association between hemodialysis (HD)-rela...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000368980

    authors: Calice-Silva V,Hussein R,Yousif D,Zhang H,Usvyat L,Campos LG,von Gersdorff G,Schaller M,Marcelli D,Grassman A,Etter M,Xu X,Kotanko P,Pecoits-Filho R

    更新日期:2015-01-01 00:00:00

  • Peritoneal membrane evaluation in routine clinical practice.

    abstract:BACKGROUND/AIMS:Establishment of reference values for small solute transport, sodium sieving and effluent CA125 with 3.86% (4 h) peritoneal equilibration test (PET), and comparison with fast-fast PET with regard to small solute transport categories. METHODS:Cross-sectional study; 69 prevalent patients. Sodium sieving ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000113009

    authors: Rodrigues AS,Silva S,Bravo F,Oliveira JC,Fonseca I,Cabrita A,Krediet RT

    更新日期:2007-01-01 00:00:00

  • Impact of acute renal failure on the relationship between N-terminal pro-B-type natriuretic peptide and hemodynamic parameters.

    abstract:BACKGROUND:We studied the influence of acute renal failure (ARF) on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hemodynamic parameters. METHODS:The echocardiographic parameters and NT-proBNP levels were compared between 26 mechanically ventilated patients with ARF requiring conti...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322259

    authors: Balik M,Jabor A,Otahal M,Waldauf P,Pavlisova M

    更新日期:2011-01-01 00:00:00

  • A zebrafish model for uremic toxicity: role of the complement pathway.

    abstract::Many organic solutes accumulate in end-stage renal disease (ESRD) and some are poorly removed with urea-based prescriptions for hemodialysis. However, their toxicities have been difficult to assess. We have employed an animal model, the zebrafish embryo, to test the toxicity of uremic serum compared to control. Serum ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000348456

    authors: Berman N,Lectura M,Thurman J,Reinecke J,Raff AC,Melamed ML,Reinecke J,Quan Z,Evans T,Meyer TW,Hostetter TH

    更新日期:2013-01-01 00:00:00

  • Cell-based strategies for the treatment of kidney dysfunction: a review.

    abstract::Conventional treatment of acute and chronic renal diseases has focused on solute removal. Novel strategies aim to treat the multifactorial disease states of acute kidney injury and chronic kidney disease by mitigating inflammation. Cell-based technologies for the treatment of kidney dysfunction fall under two broad ca...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000341649

    authors: Pino CJ,Yevzlin AS,Tumlin J,Humes HD

    更新日期:2012-01-01 00:00:00

  • Determinants of N-terminal pro-brain natriuretic peptide variation in hemodialysis patients and prediction of survival.

    abstract:BACKGROUND/AIMS:N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000360267

    authors: Snaedal S,Qureshi AR,Carrero JJ,Heimbürger O,Stenvinkel P,Bárány P

    更新日期:2014-01-01 00:00:00

  • Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients.

    abstract:BACKGROUND:Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality i...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000366124

    authors: João Matias P,Azevedo A,Laranjinha I,Navarro D,Mendes M,Ferreira C,Amaral T,Jorge C,Aires I,Gil C,Ferreira A

    更新日期:2014-01-01 00:00:00