Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients.

Abstract:

BACKGROUND:Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients. METHODS:We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l. RESULTS:Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m(2)) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors. CONCLUSIONS:Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.

journal_name

Blood Purif

journal_title

Blood purification

authors

João Matias P,Azevedo A,Laranjinha I,Navarro D,Mendes M,Ferreira C,Amaral T,Jorge C,Aires I,Gil C,Ferreira A

doi

10.1159/000366124

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

244-52

issue

3-4

eissn

0253-5068

issn

1421-9735

pii

000366124

journal_volume

38

pub_type

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