Benefit of glucose-free dialysis solutions on glucose and lipid metabolism in peritoneal dialysis patients.

Abstract:

BACKGROUND:Glucose absorbed from conventional peritoneal dialysis (PD) solutions contributes to unfavorable metabolic effects. Its replacement with a glucose-free osmotic agent such as icodextrin (ID) or amino acids (AA) may have some benefit on glucose and lipid metabolism. METHODS:Serum lipids, insulin sensitivity and substrate oxidation (calorimetry) were measured before and after 8 weeks use of ID or AA in 22 patients. Calorimetry and blood tests (HbA1c, lipids) were also performed after 8 weeks of simultaneous use of ID and AA in 8 patients. RESULTS:Cholesterol declined during the use of AA (4.8 +/- 0.3-4.5 +/- 0.3 mmol/l, p = 0.045). Triglycerides decreased during the use of both ID (2.2 +/- 0.2-1.9 +/- 0.1 mmol/l, p = 0.019) and AA (1.9 +/- 0.2-1.6 +/- 0.1 mmol/l, p = 0.024). Free fatty acids declined during the use of AA. There were no significant changes in insulin sensitivity. Glucose oxidation decreased and lipid oxidation increased during the use of ID, the changes in substrate oxidation were accentuated during the simultaneous use of ID and AA. CONCLUSION:Replacement of glucose with ID or AA had a benefit on glucose and lipid metabolism.

journal_name

Blood Purif

journal_title

Blood purification

authors

Martikainen T,Teppo AM,Gronhagen-Riska C,Ekstrand A

doi

10.1159/000086553

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

303-10

issue

4

eissn

0253-5068

issn

1421-9735

pii

86553

journal_volume

23

pub_type

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