Effects of hemoadsorption with a novel adsorbent on sepsis: in vivo and in vitro study.

Abstract:

BACKGROUND/AIMS:Hemoadsorption may improve outcomes for sepsis by removing circulating cytokines. We tested a new sorbent used for hemoadsorption. METHODS:CTR sorbent beads were filled into columns of three sizes: CTR0.5 (0.5 ml), CTR1 (1.0 ml) and CTR2 (2.0 ml) and tested using IL-6 capture in vitro. Next, rats were subjected to cecal ligation and puncture and randomly assigned to hemoadsorption with CTR0.5, CTR1, CTR2 or sham treatment. Plasma biomarkers were measured. RESULTS:In vitro, IL-6 removal was accelerated with increasing bead mass. In vivo, TNF, IL-6, IL-10, high mobility group box1, and cystatin C were significantly lower 24 h after CTR2 treatment. Seven-day survival rate was 50, 64, 63, and 73% for the sham, CTR0.5, CTR1, CTR2, respectively. CONCLUSION:CTR appeared to have a favorable effect on kidney function despite no immediate effects on cytokine removal. However, CTR2 beads did result in a late decrease of cytokines.

journal_name

Blood Purif

journal_title

Blood purification

authors

Zhang J,Peng Z,Maberry D,Volpe J,Kimmel JD,Federspiel WJ,Kellum JA

doi

10.1159/000381006

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

239-45

issue

1-3

eissn

0253-5068

issn

1421-9735

pii

000381006

journal_volume

39

pub_type

杂志文章
  • Finances of the independent dialysis facility.

    abstract::Medicare pays 80% of the cost of dialysis treatment and associated medications. Congress directed the Centers for Medicare and Medicaid Services (CMS) to develop both a process of regular and more or less "automatic" updates of composite rate setting and "bundling" as much of the laboratory and ancillary medications a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000096390

    authors: DeOreo PB

    更新日期:2007-01-01 00:00:00

  • Adequacy of peritoneal dialysis--where are we going?

    abstract::The present working hypothesis regarding adequacy issues in peritoneal dialysis is that dialysis is a major determinant of protein intake and therefore nutritional status in these patients. Present data however is controversial. This is in part due to differences in methodology and the calculations used for the data p...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000170201

    authors: Burkart JM

    更新日期:1995-01-01 00:00:00

  • Heart rate variability in peritoneal dialysis patients: what is the role of residual renal function?.

    abstract:BACKGROUND:The relationship between heart rate variability (HRV) and residual renal function (RRF) has not been elucidated previously. METHODS:In this cross-sectional study, HRV was evaluated in 71 peritoneal dialysis patients. Patients were divided into RRF decline group, RRF stable group and anuric group. RESULTS:R...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338184

    authors: Tang W,Li LX,Pei J,Wang T

    更新日期:2012-01-01 00:00:00

  • Cytokines and biocompatibility.

    abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

  • Prevention and management of dialysis catheter complications in the intensive care unit.

    abstract::Dialysis dependence at hospital discharge after acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) is found in 10-15% of survivors. In case of severe AKI in the ICU, it is necessary to reconcile two objectives: the creation of an adequate temporary angioaccess for RRT ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000341721

    authors: Wilson P,Lertdumrongluk P,Leray-Moragués H,Chenine-Koualef L,Patrier L,Canaud B

    更新日期:2012-01-01 00:00:00

  • Dialyzer reprocessing using heat. Scientific and technical considerations.

    abstract::Reprocessing of used dialyzers with chemical disinfectants is practiced commonly in the United States and in some areas of Western Europe. Concern over residual toxic or allergenic agents has encouraged the search for other practical methods to disinfect or sterilize used hemodialyzers. The use of moist heat has been ...

    journal_title:Blood purification

    pub_type:

    doi:10.1159/000170132

    authors: Holmes CJ

    更新日期:1993-01-01 00:00:00

  • Effects of calcitriol on type 5b tartrate-resistant acid phosphatase and interleukin-6 in secondary hyperparathyroidism.

    abstract:BACKGROUND/AIMS:Secondary hyperparathyroidism (SHP) is characterized by high bone turnover and elevated serum bone remodeling markers. Elevation of serum interleukin-6 (IL-6) levels is also characteristic of end-stage renal disease. This study investigates the effects of intravenous calcitriol on serum bone resorptive ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000094899

    authors: Lu KC,Tseng CF,Wu CC,Yeung LK,Chen JS,Chao TY,Janckila AJ,Yam LT,Chu P

    更新日期:2006-01-01 00:00:00

  • Acute suppression of parathyroid activity during hemofiltration.

    abstract::Hemofiltration (HF) induces a significant reduction in parathormone (PTH). This effect is related not only to the convective removal of PTH molecules but also to the biological suppression of parathyroid glands by plasma-ionized calcium (iCa) increase. The acute inhibitory effect on parathyroid gland activity, ionized...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170236

    authors: Panichi V,Bianchi AM,Andreini B,Casarosa L,Migliori M,De Pietro S,Ferdeghini M,Palla R

    更新日期:1996-01-01 00:00:00

  • Impact of residual renal function on volume status in chronic renal failure.

    abstract::During the past few years, it has become increasingly evident that residual renal function (RRF) is an important and independent predictor of poor outcome in patients with chronic kidney disease (CKD). Although the causes of this observation are not fully understood, it appears that the loss of RRF impairs both fluid ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000078699

    authors: Pecoits-Filho R,Gonçalves S,Barberato SH,Bignelli A,Lindholm B,Riella MC,Stenvinkel P

    更新日期:2004-01-01 00:00:00

  • Associations between global population health indicators and dialysis variables in the Monitoring Dialysis Outcomes (MONDO) consortium.

    abstract:BACKGROUND:The number of patients receiving renal replacement therapy (RRT) increases annually and worldwide. Differences in the RRT incidence, prevalence, and modality vary between regions and countries for reasons yet to be clarified. AIMS:Gain a better understanding of the association between hemodialysis (HD)-rela...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000368980

    authors: Calice-Silva V,Hussein R,Yousif D,Zhang H,Usvyat L,Campos LG,von Gersdorff G,Schaller M,Marcelli D,Grassman A,Etter M,Xu X,Kotanko P,Pecoits-Filho R

    更新日期:2015-01-01 00:00:00

  • Effect of prolonged subcutaneous implantation of peritoneal catheter on peritonitis rate during CAPD: a prospective randomized study.

    abstract::We conducted a prospective randomized controlled study to confirm our earlier observation that prolonged subcutaneous implantation of peritoneal catheter reduced peritonitis rate when compared to retrospective data from patients with catheters placed by conventional access technique. A total of 60 patients were random...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000014331

    authors: Park MS,Yim AS,Chung SH,Lee EY,Cha MK,Kim JH,Song KI,Han DC,Hwang SD,Moon C,Lee HB

    更新日期:1998-01-01 00:00:00

  • Changes in circulating levels of calcitonin gene-related peptide and nitric oxide metabolites in septic patients during direct hemoperfusion with polymyxin B-immobilized fiber.

    abstract:BACKGROUND/AIMS:This study evaluated the mechanism of hemodynamic improvement in polymyxin B-immobilized fiber (PMX) treatment. METHODS:Fifteen septic patients with endotoxemia and/or gram negative infection were treated with PMX. Plasma concentrations of calcitonin gene-related peptide (CGRP) and nitric oxide metabol...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000070696

    authors: Shimizu T,Hanasawa K,Tani T,Endo Y,Kurumi Y,Ikeda T,Fujita N,Morita H,Imaizumi H,Sato T,Katayama H

    更新日期:2003-01-01 00:00:00

  • Vascular access vulnerability in intensive hemodialysis: a significant Achilles' heel?

    abstract:BACKGROUND:Frequent hemodialysis (HD) may be associated with an increased risk of vascular access complications. Studies addressing vascular access outcomes in frequent HD show conflicting results. METHODS:We searched Medline for trials looking at vascular access outcomes in frequent HD. RESULTS:Nineteen studies met ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000362106

    authors: Cornelis T,Usvyat LA,Tordoir JH,Wang Y,Wong M,Leunissen KM,van der Sande FM,Kotanko P,Kooman JP

    更新日期:2014-01-01 00:00:00

  • Risk Factors of Central Venous Catheter-Related Bloodstream Infection for Continuous Renal Replacement Therapy in Kidney Intensive Care Unit Patients.

    abstract:BACKGROUND:The incidence of central venous catheter-related bloodstream infection (CRBSI) for continuous renal replacement therapy (CRRT) in kidney intensive care unit (ICU) patients is worthy of particular attention and recently, we analyzed clinical characteristics and risk factors of CRBSI for CRRT in our kidney ICU...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000495024

    authors: Cheng S,Xu S,Guo J,He Q,Li A,Huang L,Liu Z,Li S

    更新日期:2019-01-01 00:00:00

  • Presepsin and Procalcitonin Levels as Markers of Adverse Postoperative Complications and Mortality in Cardiac Surgery Patients.

    abstract::Backgound: This study was aimed at evaluating the presepsin and procalcitonin levels to predict adverse postoperative complications and mortality in cardiac surgery patients. METHODS:A total of 122 cardiac surgery patients were enrolled for the study. Presepsin and procalcitonin levels were measured 48 h after the pr...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000494207

    authors: Clementi A,Virzì GM,Muciño-Bermejo MJ,Nalesso F,Giavarina D,Carta M,Brocca A,de Cal M,Hinna Danesi T,Zanella M,Marchionna N,Brendolan A,Battaglia GG,Salvador L,Ronco C

    更新日期:2019-01-01 00:00:00

  • Antioxidant enzymes--superoxide dismutase and glutathione peroxidase--in haemodialyzed patients.

    abstract::The biological effect of oxygen-reactive species controlled by antioxidant mechanisms are exerted on the basis of antioxidant enzymes and substrates. In this study, the activities of antioxidant enzymes-superoxide dismutase (SOD) and glutathione peroxidase (GPx)-were determined in the erythrocytes of patients on regul...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170269

    authors: Zima T,Stípek S,Crkovská J,Nĕmecek K,Pláteník J,Bártová V,Tesar V

    更新日期:1996-01-01 00:00:00

  • Advanced glycation end products and β(2)-microglobulin as predictors of carpal tunnel syndrome in hemodialysis patients.

    abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338923

    authors: Busch M,Schwenzky A,Franke S,Stein G,Wolf G

    更新日期:2012-01-01 00:00:00

  • Blood Pressure of Maintenance Hemodialysis Patients in the Dalmatian Region of Croatia: Differences between Hospital and Out-of-Hospital Dialysis Centers.

    abstract:AIMS:This study was aimed at comparing the incidence of arterial hypertension and blood pressure (BP) variance in hospital and out-of-hospital hemodialysis (HD) patients during HD sessions. METHODS:A cross-sectional study was conducted for 1 week at all the HD centers in Dalmatia, Croatia. The pre-, intra-, and post-d...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000474931

    authors: Gulin M,Klarić D,Ilić M,Radić J,Kovačić V,Šain M

    更新日期:2017-01-01 00:00:00

  • The Rise of Expanded Hemodialysis.

    abstract::The low water permeability feature of original cellulosic membranes was considered an advantage in the absence of dialysis equipment that are capable of controlling water removal. The advent of ultrafiltration control systems led to the development and use of high-flux (HF) membranes that allowed improved middle molec...

    journal_title:Blood purification

    pub_type: 社论

    doi:10.1159/000476012

    authors: Ronco C

    更新日期:2017-01-01 00:00:00

  • Improving Erythropoiesis Stimulating Agent Hyporesponsiveness in Hemodialysis Patients: The Role of Hepcidin and Hemodiafiltration Online.

    abstract::Hyporesponsiveness to erythropoietin stimulating agents (ESAs) is a condition associated with increased mortality. Even after identifying the condition, the causes are difficult to treat and only partially reversible in end-stage renal disease patients. Thus, the role of more recent hemodialysis (HD) techniques in imp...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000485314

    authors: Rosati A,Ravaglia F,Panichi V

    更新日期:2018-01-01 00:00:00

  • Peritoneal membrane failure in peritoneal dialysis patients.

    abstract::A review is given of the conditions associated with peritoneal membrane failure, and the possible causes. Ultrafiltration failure is the most important manifestation. It is mostly associated with high transport rates of low molecular weight solutes suggesting the presence of a large vascular surface area. Enlargement ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000065202

    authors: Krediet RT,Van Esch S,Smit W,Michels WM,Zweers MM,Ho-Dac-Pannekeet MM,Struijk DG

    更新日期:2002-01-01 00:00:00

  • Assessment of inflow of endotoxin and its fragments in patients on maintenance hemodialysis.

    abstract:BACKGROUND:We estimated the flow of endotoxins (ET) from dialysates into the blood of patients on hemodialysis (HD) using limulus amebocyte lysate (LAL) assays and endotoxin activity (EA) determined by neutrophil respiratory burst activity. METHODS:A cross-sectional study compared groups given ultrapure bicarbonate (n...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322622

    authors: Suzuki H,Honda H,Kato N,Michihata T,Takahashi K,Shishido K,Akizawa T

    更新日期:2011-01-01 00:00:00

  • Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

    abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000493178

    authors: Leypoldt JK,Vonesh EF

    更新日期:2019-01-01 00:00:00

  • Nocturnal Hemodialysis Compared with Conventional Dialysis for End-Stage Renal Disease Treatment in Polycystic Kidney Disease Patients.

    abstract:BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of end-stage renal disease (ESRD). Little is known about outcomes after in-center nocturnal hemodialysis (NHD) treatment in ADPKD patients with ESRD. OBJECTIVES:This study aimed to evaluate the effects of in-center NHD ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000503679

    authors: Xue C,Sun B,Ye X,Zhou C,Yang B,Zhang L,Yu S

    更新日期:2020-01-01 00:00:00

  • Development of intermittent infusion hemodiafiltration using ultrapure dialysis fluid with an automated dialysis machine.

    abstract::To reduce the potential occurrence of hypotension during a dialysis treatment, intermittent infusion hemodiafiltration (I-HDF) using back filtration with an ultrapure dialysis fluid was developed. Under typical I-HDF treatment conditions, some 200-300 ml of ultrapure dialysis fluid was infused into the blood component...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000346371

    authors: Mineshima M,Eguchi K

    更新日期:2013-01-01 00:00:00

  • Peritonitis - does peritoneal dialysis modality make a difference?

    abstract:BACKGROUND/AIMS:Peritonitis remains a significant problem for patients on peritoneal dialysis (PD). There is a certain amount of controversy as to whether peritoneal modality is itself a risk factor for peritonitis, with one modality higher than another. METHODS:A literature review was done (August 2009) searching und...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000245641

    authors: Piraino B,Sheth H

    更新日期:2010-01-01 00:00:00

  • Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality?

    abstract::Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical condition...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000360520

    authors: Kanbay M,Solak Y,Gaipov A,Takir M,Weiner DE

    更新日期:2014-01-01 00:00:00

  • Body Fluids in End-Stage Renal Disease: Statics and Dynamics.

    abstract:BACKGROUND:Abnormalities in fluid status in hemodialysis (HD) patients are highly prevalent and are related to adverse outcomes. SUMMARY:The inherent discontinuity of the HD procedure in combination with an often compromised cardiovascular response is a major contributor to this phenomenon. In addition, systemic infla...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000494583

    authors: Kooman JP,van der Sande FM

    更新日期:2019-01-01 00:00:00

  • Access blood flow and the risk of complications in mature forearm and upper arm arteriovenous fistulas.

    abstract:BACKGROUND/AIMS:Optimization of vascular access use in the 'fistula first' era requires comprehension of its clinical behavior. Little is known about mature arteriovenous fistula (AVF) performance and the role of fistula location. Widely used access flow (Qa) was used to analyze complication risks and functionality aft...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000197561

    authors: Huijbregts HJ,Bots ML,Wittens CH,Schrama YC,Blankestijn PJ

    更新日期:2009-01-01 00:00:00

  • Factors predicting erythropoietin resistance among maintenance hemodialysis patients.

    abstract:BACKGROUND:Erythropoiesis-stimulating agent (ESA) resistance remains incompletely understood among hemodialysis (HD) patients. METHOD:A retrospective, multicenter study was designed to analyze data from 1,934 patients followed for up to two years. The outcome measure was the erythropoietin resistance index (ERI), defi...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000335256

    authors: Mallick S,Rafiroiu A,Kanthety R,Iqbal S,Malik R,Rahman M

    更新日期:2012-01-01 00:00:00