Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

Abstract:

BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely, stdKt/V = N × (URR + UFV/V), where N is the number of treatments per week, URR is urea reduction ratio per treatment, UFV is ultrafiltration volume per treatment, and V is postdialysis urea distribution volume. URR required corrections for postdialysis rebound and intradialytic urea generation. We compared the accuracy of this approach with previous equations for stdKt/V by numerical simulations using a 2-compartment model of urea kinetics for thrice-weekly and more frequent HD prescriptions. RESULTS:The proposed equation based on urea mass removed predicted values of stdKt/V that are equivalent to those calculated by previous equations for stdKt/V. CONCLUSION:This work provides a novel approach for calculating stdKt/V during HD and strengthens the theoretical understanding of stdKt/V.

journal_name

Blood Purif

journal_title

Blood purification

authors

Leypoldt JK,Vonesh EF

doi

10.1159/000493178

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

62-68

issue

1-3

eissn

0253-5068

issn

1421-9735

pii

000493178

journal_volume

47

pub_type

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