Platelet activation during haemodialysis: comparison of cuprammonium rayon and polysulfone membranes.

Abstract:

BACKGROUND/AIM:Haemodialysis-treated patients are at a high risk of developing cardiovascular disease. Part of this risk may be attributable to the type of the dialysis membrane used. We evaluated whether different dialysis membranes differ with respect to platelet activation. METHODS:In a randomized crossover trial, the platelet activation was measured in 14 patients treated with two different dialyzers (cuprammonium rayon membrane and polysulfone membrane). We compared the platelet activation over the dialyzer and between dialyzers after several weeks of dialysis. RESULTS:There were no differences between the two dialyzers in platelet activation over the dialyzer. After 2 weeks, however, the expression of CD62P, CD63, and PAC-1 was statistically significantly lower after cuprammonium membrane treatment than after polysulfone membrane treatment (mean fluorescence intensity in arbitrary units 8.0 vs. 11.1, 2.64 vs. 4.01, and 5.61 vs. 9.74, respectively). CONCLUSION:Dialysis with a polysulfone membrane seems to lead to more platelet activation than dialysis with a cuprammonium membrane.

journal_name

Blood Purif

journal_title

Blood purification

authors

Thijs A,Grooteman MP,Zweegman S,Nubé MJ,Huijgens PC,Stehouwer CD

doi

10.1159/000108628

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

389-94

issue

5-6

eissn

0253-5068

issn

1421-9735

pii

000108628

journal_volume

25

pub_type

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