Abstract:
BACKGROUND:To study calcium homeostasis during citrate-based compared to nadroparin-based CVVH in critically-ill patients with acute renal failure. METHODS:11 patients were observed during citrate anticoagulation, 9 with nadroparin and 10 controls. Citrate was chosen for patients with active or at risk for bleeding. RESULTS:The controls had, at 24 h, a median serum iCa of 1.1 mmol/l, the citrate group 0.87 mmol/l and the nadroparin group 1.1 mmol/l (citrate vs. control p = 0.001, citrate vs. nadroparin p = 0.002). At 48 h, iCa was not significantly different anymore. Ca balance was negative for the citrate group in contrast to the nadroparin group (p = 0.012). Median serum PTH was higher (30.0 pmol/l vs. 6.5 pmol/l, p = 0.003) in the citrate group. CONCLUSION:With a relative low target-serum-iCa (0.8-0.9 mmol/l) citrate CVVH-treated patients had a negative daily calcium balance and a temporarily lower iCa level resulting in an enhanced PTH response in comparison to nadroparin.
journal_name
Blood Purifjournal_title
Blood purificationauthors
van der Voort PH,Postma SR,Kingma WP,Boerma EC,de Heide LJ,Bakker AJdoi
10.1159/000101853subject
Has Abstractpub_date
2007-01-01 00:00:00pages
267-73issue
3eissn
0253-5068issn
1421-9735pii
000101853journal_volume
25pub_type
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pub_type: 临床试验,杂志文章
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