Regulation of the response to bacterial lipopolysaccharide by endogenous and exogenous lipopolysaccharide binding proteins.

Abstract:

:Bactericidal/permeability-increasing protein (BPI) is a natural constituent of human neutrophils. Recombinant BPI has been shown to bind to bacterial lipopolysaccharide (LPS), and to neutralize the ability of LPS to stimulate inflammatory cells in vitro and in vivo. BPI shares sequence homology and immunocrossreactivity with another endogenous LPS binding protein, lipopolysaccharide binding protein (LBP). Despite the homology, these proteins have opposite effects on LPS. LBP mediates cell activation by low, otherwise nonstimulatory concentrations, while BPI neutralizes LPS bioactivity. Exogenous LPS binding proteins in the form of monoclonal antibodies have been developed with the goal of generating antiendotoxin therapeutics to treat gram-negative sepsis and related syndromes. Here we show that LPS-binding and neutralizing properties of BPI compare favorably with two monoclonal antibodies tested, HA-1A and XMMEN-OE5. BPI also competes effectively with LBP for LPS. Thus, BPI may represent an endogenous LPS-regulatory molecule suitable for use as a potent antiendotoxin therapeutic.

journal_name

Blood Purif

journal_title

Blood purification

authors

Marra MN,Thornton MB,Snable JL,Leong S,Lane J,Wilde CG,Scott RW

doi

10.1159/000170107

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

134-40

issue

2

eissn

0253-5068

issn

1421-9735

journal_volume

11

pub_type

杂志文章
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    authors: Naseeb U,Shafqat J,Jägerbrink T,Zarina S,Alvestrand A,Jörnvall H,Axelsson J

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    doi:10.1159/000086553

    authors: Martikainen T,Teppo AM,Gronhagen-Riska C,Ekstrand A

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  • Dietary and pharmacological control of calcium and phosphate metabolism in dialysis patients.

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    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000209250

    authors: Bover J,Andrés E,Lloret MJ,Aguilar A,Ballarín J

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  • Spontaneous Left Renal Subcapsular Hematoma and Right Hip Hematoma in a Hemodialysis Patient: A Case Report and Review of the Literature.

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    journal_title:Blood purification

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    authors: Ye M,Liu Y,Zhou L,Wang C,Fu X,Peng Y,Liu H

    更新日期:2016-01-01 00:00:00

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    abstract::During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free bio...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000320133

    authors: Borrelli S,Minutolo R,De Nicola L,Zamboli P,Iodice C,De Paola A,De Simone E,Zito B,Guastaferro P,Nigro F,Apperti V,Iulianiello G,Credendino O,Iacono G,Di Serafino A,D'Apice L,Saviano C,Sarti A,Capuano M,Genualdo R,

    更新日期:2010-01-01 00:00:00

  • Angiotensin Converting Enzyme Inhibitor Dialyzability and Outcomes in Older Patients Receiving Hemodialysis.

    abstract:BACKGROUND/AIMS:Some angiotensin converting enzyme (ACE) inhibitors are efficiently removed from circulation by hemodialysis ('high dialyzability'), whereas others are not ('low dialyzability'). In patients receiving hemodialysis, this may influence the effectiveness of ACE inhibitors. METHODS:Using linked healthcare ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000438821

    authors: Weir MA,Fleet JL,Dixon SN,Jain AK,Oliver M,Wald R,McIntyre C,Garg AX

    更新日期:2015-01-01 00:00:00

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    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000169562

    authors: Bergström J,Alvestrand A,Bucht H,Gutierrez A

    更新日期:1988-01-01 00:00:00

  • Clinical value of standardized equilibration tests in CAPD patients.

    abstract::Peritoneal transport rates, a critical determinant of peritoneal dialysis efficiency, vary widely among patients and may be easily categorized by standardized peritoneal equilibration test. Measurements of creatinine and glucose transfer are particularly useful in selecting optimal dialysis prescription. Patients with...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169582

    authors: Twardowski ZJ

    更新日期:1989-01-01 00:00:00

  • Heart rate variability in peritoneal dialysis patients: what is the role of residual renal function?.

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338184

    authors: Tang W,Li LX,Pei J,Wang T

    更新日期:2012-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000356366

    authors: Basso F,Berdin G,Virzì GM,Mason G,Piccinni P,Day S,Cruz DN,Wjewodzka M,Giuliani A,Brendolan A,Ronco C

    更新日期:2013-01-01 00:00:00

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    abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

  • Fluid overload in critically ill patients with acute kidney injury.

    abstract::Fluid overload may occur in critically ill patients as a result of aggressive resuscitation therapies. In such circumstances, persistent fluid overload must be avoided since it does not benefit the patient while it may be harmful. In the septic patient, early volume expansion seems to be beneficial. Beyond that thresh...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000287776

    authors: Cerda J,Sheinfeld G,Ronco C

    更新日期:2010-01-01 00:00:00

  • Use of Continuous Glucose Monitoring in Patients with Diabetes Mellitus on Peritoneal Dialysis: Correlation with Glycated Hemoglobin and Detection of High Incidence of Unaware Hypoglycemia.

    abstract:INTRODUCTION:Glycated hemoglobin is used to assess diabetic control although its accuracy in dialysis has been questioned. How does it compare to the Continuous Glucose Monitoring System (CGMS) in peritoneal dialysis (PD) patients? METHODS:We conducted a retrospective analysis of 60 insulin-treated diabetic patients o...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000439242

    authors: Qayyum A,Chowdhury TA,Oei EL,Fan SL

    更新日期:2016-01-01 00:00:00

  • Advanced glycation end products and β(2)-microglobulin as predictors of carpal tunnel syndrome in hemodialysis patients.

    abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000338923

    authors: Busch M,Schwenzky A,Franke S,Stein G,Wolf G

    更新日期:2012-01-01 00:00:00

  • Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.

    abstract::Tranquilizers, analgetics and antidepressants are applied in different ranges in the treatment of patients on hemodialysis. Due to many different pharmacokinetic properties, no perfect rules for dosage in acute or chronic hemodialysis exist. Adequate applicable drugs without adaptation disregarding different states of...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169404

    authors: Forycki Z,Martens F,Thalhofer S,Ibe K

    更新日期:1985-01-01 00:00:00

  • Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant.

    abstract:BACKGROUND/AIMS:Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. METHODS:We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000336094

    authors: Zhang Y,Ning J,Veeraragoo P,Li Y,Dai S

    更新日期:2012-01-01 00:00:00

  • Haemodialysis fluid: composition and clinical importance.

    abstract::Dialysis fluid is produced by the blending of treated water with electrolytes at the patients bed side. Its preparation and composition are important elements of treatment optimisation since many of the constituents play a role in patient well-being. Ideally the composition of the dialysis fluid should match that of p...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000096400

    authors: Hoenich NA,Ronco C

    更新日期:2007-01-01 00:00:00

  • Impact of hemodialysis therapy on anemia of chronic kidney disease: the potential mechanisms.

    abstract::A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to und...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000329573

    authors: Bowry SK,Gatti E

    更新日期:2011-01-01 00:00:00

  • Why assistive technology is needed for probing of dry weight.

    abstract::Despite advancements in dialysis therapy, the subjective clinical examination still remains the standard of care in managing volume removal in chronic dialysis. While there is no definitive trial establishing that dry weight management guided by an assistive technology is superior to the clinical method, there is ampl...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000321840

    authors: Sinha AD

    更新日期:2011-01-01 00:00:00

  • Chronic kidney disease and the transplant recipient.

    abstract::The recent Kidney Disease Outcomes Quality Initiative (K/DOQI) classification of chronic kidney disease (CKD) includes transplant recipients. Although there are important differences between kidney transplant recipients (KTRs) and patients with native kidney disease, the inclusion of KTRs along with other CKD patients...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000067871

    authors: Gill JS,Pereira BJ

    更新日期:2003-01-01 00:00:00

  • Effects of AST-120 on blood concentrations of protein-bound uremic toxins and biomarkers of cardiovascular risk in chronic dialysis patients.

    abstract:BACKGROUND:Removal of protein-bound uremic toxins by dialysis therapy is limited. The effect of oral adsorbent AST-120 in chronic dialysis patients has rarely been investigated. METHODS:AST-120 was administered 6.0 g/day for 3 months in 69 chronic dialysis patients. The blood concentrations of indoxyl sulfate, p-creso...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000357641

    authors: Lee CT,Hsu CY,Tain YL,Ng HY,Cheng BC,Yang CC,Wu CH,Chiou TT,Lee YT,Liao SC

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  • C-reactive protein in end-stage renal disease: are there reasons to measure it?

    abstract::Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this population, inflammation (a common phenomenon in ESRD), and other non-traditional ri...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000082014

    authors: Stenvinkel P,Lindholm B

    更新日期:2005-01-01 00:00:00

  • Blood Pressure of Maintenance Hemodialysis Patients in the Dalmatian Region of Croatia: Differences between Hospital and Out-of-Hospital Dialysis Centers.

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000474931

    authors: Gulin M,Klarić D,Ilić M,Radić J,Kovačić V,Šain M

    更新日期:2017-01-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1159/000362106

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  • Significance of Content of the Reticulocyte Hemoglobin in the Management of Renal Anemia.

    abstract::Optimal iron level in hemodialysis patients remains a subject of debate. The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow. CHr is not influenced by any factors that measure direct hemoglobin (Hb) of reticulocytes and...

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    pub_type: 杂志文章

    doi:10.1159/000496641

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  • Failure of naloxone in reversal hemodialysis-induced hypotension.

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169411

    authors: Sturani A,Degli Esposti E,Chiarini C,Spongano M,Santoro A,Zucchelli P

    更新日期:1985-01-01 00:00:00

  • Novel insights into the pathobiology of the vascular access - do they translate into improved care?

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    pub_type: 杂志文章,评审

    doi:10.1159/000245650

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    更新日期:2010-01-01 00:00:00

  • Prevention of Intradialytic Hypotension with Intermittent Back-Filtrate Infusion Haemodiafiltration: Insights into the Underlying Mechanism.

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    pub_type: 杂志文章,评审

    doi:10.1159/000503878

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    pub_type: 杂志文章,评审

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