Is Sclerostin Level Associated with Cardiovascular Diseases in Hemodialysis Patients?

Abstract:

BACKGROUND/AIMS:The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS:Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RESULTS:Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses. Sclerostin associated positively with male gender and statin use but negatively with PTH in multivariate regression analyses. During observation, 30 fatal or nonfatal CVEs were observed. While univariate correlation analysis showed a positive association between PWV and sclerostin, there was no relation between the two in multivariate regression analysis. CONCLUSION:Further studies are needed to understand the role of sclerostin in predicting PWV changes in HD patients.

journal_name

Blood Purif

journal_title

Blood purification

authors

Kundakci Gelir G,Sengul S,Nergizoglu G,Ertürk S,Duman N,Kutlay S

doi

10.1159/000487223

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

118-125

issue

2

eissn

0253-5068

issn

1421-9735

pii

000487223

journal_volume

46

pub_type

杂志文章
  • Impact of hemodialysis therapy on anemia of chronic kidney disease: the potential mechanisms.

    abstract::A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to und...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000329573

    authors: Bowry SK,Gatti E

    更新日期:2011-01-01 00:00:00

  • Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

    abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000493178

    authors: Leypoldt JK,Vonesh EF

    更新日期:2019-01-01 00:00:00

  • Influence of plasma exchange on serum levels of cytokines and adhesion molecules in ANCA-positive renal vasculitis.

    abstract:BACKGROUND:Increased serum levels of proinflammatory cytokines may contribute to the organ damage in active antineutrophil cytoplasmic antigen (ANCA)-positive renal vasculitis. Plasma exchange (PE) may influence the activity of vasculitis not only by removing pathogenic autoantibodies, but also by lowering the serum le...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014316

    authors: Tesar V,Jelínková E,Masek Z,Jirsa M Jr,Zabka J,Bartůnková J,Stejskalová A,Janatková I,Zima T

    更新日期:1998-01-01 00:00:00

  • Association between vitamin D receptor gene polymorphisms and susceptibility to chronic kidney disease and periodontitis.

    abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of severa...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000109235

    authors: de Souza CM,Braosi AP,Luczyszyn SM,Avila AR,de Brito RB Jr,Ignácio SA,Probst CM,Riella MC,Sotomaior VS,Mira MT,Pecoits-Filho R,Trevilatto PC

    更新日期:2007-01-01 00:00:00

  • Plasma C-reactive protein in hemodialysis patients: a cross-sectional, longitudinal clinical survey.

    abstract::In hemodialysis patients, C-reactive protein (CRP), an acute-phase reactant, is a sensitive and independent marker of malnutrition, anemia, and amyloidosis. The aim of the present studies was to evaluate CRP and interleukin 6 levels in plasma samples from long-term hemodialysis patients on different extracorporeal mod...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000014405

    authors: Panichi V,Migliori M,De Pietro S,Metelli MR,Taccola D,Perez R,Palla R,Rindi P,Cristofani R,Tetta C

    更新日期:2000-01-01 00:00:00

  • Correlation between pulse wave velocity and fluid distribution in hemodialysis patients.

    abstract:BACKGROUND:In this study, we focused on whether volume overload plays a role in the development of arterial stiffness. METHODS:Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was as...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000199432

    authors: Zheng D,Cheng LT,Zhuang Z,Gu Y,Tang LJ,Wang T

    更新日期:2009-01-01 00:00:00

  • Cytokines and biocompatibility.

    abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

  • Current Focuses in Serum Lipid Abnormalities in Dialysis Patients.

    abstract:BACKGROUND:Dyslipidemia is a common metabolic complication in patients with chronic kidney disease and is detected as changes in lipoprotein concentrations in serum. SUMMARY:Recently, other features of lipid abnormalities have been described, such as alterations in serum n-3 polyunsaturated fatty acids, cholesterol me...

    journal_title:Blood purification

    pub_type: 评论,杂志文章

    doi:10.1159/000441581

    authors: Shoji T

    更新日期:2015-01-01 00:00:00

  • Erythropoietin-induced changes in protein nutrition: quantitative assessment by urea kinetic modeling analysis.

    abstract::To evaluate objectively the effects of recombinant human erythropoietin (rHuEPO) administration on nutritional status in stable dialyzed patients, we used urea kinetic modeling (UKM) analysis and dietary protein intake evaluation by dietary assessment. Fifteen patients (9 females, 6 males; mean age 46.9 +/- 15.6 years...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169982

    authors: Canaud B,Bouloux C,Rivory JP,Taib J,Garred LJ,Florence P,Mion C

    更新日期:1990-01-01 00:00:00

  • Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered, Calcium Containing Replacement Solution.

    abstract:BACKGROUND/AIMS:Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a cit...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000452755

    authors: Kirwan CJ,Hutchison R,Ghabina S,Schwarze S,Beane A,Ramsay S,Thompson E,Prowle JR

    更新日期:2016-01-01 00:00:00

  • Development of intermittent infusion hemodiafiltration using ultrapure dialysis fluid with an automated dialysis machine.

    abstract::To reduce the potential occurrence of hypotension during a dialysis treatment, intermittent infusion hemodiafiltration (I-HDF) using back filtration with an ultrapure dialysis fluid was developed. Under typical I-HDF treatment conditions, some 200-300 ml of ultrapure dialysis fluid was infused into the blood component...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000346371

    authors: Mineshima M,Eguchi K

    更新日期:2013-01-01 00:00:00

  • Renal replacement therapy in geriatric end-stage renal disease patients: a clinical approach.

    abstract::The number of geriatric patients on dialysis is increasing. This is due to demographic factors, a wider acceptance of elderly patients on dialysis, and an earlier start of dialysis in this patient group. Recent studies have questioned the effect of dialysis on quality of life in elderly patients with severe comorbidit...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000334153

    authors: Kooman JP,Cornelis T,van der Sande FM,Leunissen KM

    更新日期:2012-01-01 00:00:00

  • Entropy of uremia and dialysis technology.

    abstract::The second law of thermodynamics applies with local exceptions to patient history and therapy interventions. Living things preserve their low level of entropy throughout time because they receive energy from their surroundings in the form of food. They gain their order at the expense of disordering the nutrients they ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000345755

    authors: Ronco C

    更新日期:2013-01-01 00:00:00

  • Defective interleukin-10 synthesis by peripheral blood mononuclear cells among hemodialysis patients.

    abstract:BACKGROUND:Interleukin-10 (IL-10), a potent regulatory monokine produced by activated mononuclear cells, provides an efficient autocrine mechanism for controlling proinflammatory cytokine synthesis. We hypothesized that defective synthesis of IL-10 could contribute to the inflammatory state in hemodialysis (HD) patient...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000066958

    authors: Perianayagam MC,Jaber BL,Guo D,King AJ,Pereira BJ,Balakrishnan VS

    更新日期:2002-01-01 00:00:00

  • Access blood flow and the risk of complications in mature forearm and upper arm arteriovenous fistulas.

    abstract:BACKGROUND/AIMS:Optimization of vascular access use in the 'fistula first' era requires comprehension of its clinical behavior. Little is known about mature arteriovenous fistula (AVF) performance and the role of fistula location. Widely used access flow (Qa) was used to analyze complication risks and functionality aft...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000197561

    authors: Huijbregts HJ,Bots ML,Wittens CH,Schrama YC,Blankestijn PJ

    更新日期:2009-01-01 00:00:00

  • Impact of residual renal function on volume status in chronic renal failure.

    abstract::During the past few years, it has become increasingly evident that residual renal function (RRF) is an important and independent predictor of poor outcome in patients with chronic kidney disease (CKD). Although the causes of this observation are not fully understood, it appears that the loss of RRF impairs both fluid ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000078699

    authors: Pecoits-Filho R,Gonçalves S,Barberato SH,Bignelli A,Lindholm B,Riella MC,Stenvinkel P

    更新日期:2004-01-01 00:00:00

  • Paired filtration dialysis: studies on efficiency, flow dynamics and hydraulic properties of the system.

    abstract::Several strategies have been proposed to increase dialysis efficiency in order to reduce dialysis treatment time. Paired filtration dialysis (two-chamber technique) is a new technique combining the advantages of highly permeable membranes and convective transport with the high depurative efficacy of diffusion. The sys...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169955

    authors: Ronco C,Feriani M,Brendolan A,Chiaramonte S,Milan M,Dell'Aquila R,Scabardi M,Bragantini L,Conz P,La Greca G

    更新日期:1990-01-01 00:00:00

  • Assessment of inflow of endotoxin and its fragments in patients on maintenance hemodialysis.

    abstract:BACKGROUND:We estimated the flow of endotoxins (ET) from dialysates into the blood of patients on hemodialysis (HD) using limulus amebocyte lysate (LAL) assays and endotoxin activity (EA) determined by neutrophil respiratory burst activity. METHODS:A cross-sectional study compared groups given ultrapure bicarbonate (n...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322622

    authors: Suzuki H,Honda H,Kato N,Michihata T,Takahashi K,Shishido K,Akizawa T

    更新日期:2011-01-01 00:00:00

  • Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant.

    abstract:BACKGROUND/AIMS:Anticoagulation in hemodialysis (HD) patients at high risk of bleeding remains an intractable problem. Simulating endothelial cells by releasing anticoagulant on the membrane may be a promising alternative. METHODS:We modified a polyacrylonitrile (PAN) dialyzer by loading argatroban into its membrane a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000336094

    authors: Zhang Y,Ning J,Veeraragoo P,Li Y,Dai S

    更新日期:2012-01-01 00:00:00

  • Peritoneal membrane evaluation in routine clinical practice.

    abstract:BACKGROUND/AIMS:Establishment of reference values for small solute transport, sodium sieving and effluent CA125 with 3.86% (4 h) peritoneal equilibration test (PET), and comparison with fast-fast PET with regard to small solute transport categories. METHODS:Cross-sectional study; 69 prevalent patients. Sodium sieving ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000113009

    authors: Rodrigues AS,Silva S,Bravo F,Oliveira JC,Fonseca I,Cabrita A,Krediet RT

    更新日期:2007-01-01 00:00:00

  • Soluble adhesion molecules and cytokines in patients with myasthenia gravis treated by plasma exchange.

    abstract::Plasma exchange (PE) is an effective therapeutic method used in patients with myasthenia gravis (MG) refractory to common therapy and/or with life-threatening respiratory complications. Except for acetylcholine receptor antibodies (AChRAbs), some other inflammatory mediators possibly activated in MG may also be remove...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014434

    authors: Tesar V,Jelínková E,Jirsa M Jr,Bakosová M,Pitha P,Chábová V

    更新日期:2000-01-01 00:00:00

  • Plasma cysteine/cystine reduction potential correlates with plasma creatinine levels in chronic kidney disease.

    abstract:BACKGROUND/AIMS:Oxidative stress has been considered a nontraditional risk factor for cardiovascular disease in the chronic kidney disease (CKD) population, possibly triggered by uremic toxicity. METHODS:A chromatographic method with coulometric detection was adapted to directly and simultaneously determine cysteine (...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000342627

    authors: Rodrigues SD,Batista GB,Ingberman M,Pecoits-Filho R,Nakao LS

    更新日期:2012-01-01 00:00:00

  • Alleviation of cisplatin nephrotoxicity: efficacy of local intra-arterial injection concomitant with hemodialysis.

    abstract::Although cis-diamminedichloroplatinum (cisplatin) is widely used in the treatment of malignant tumors, the dose administered is limited because of side effects such as nephrotoxicity. The plasma levels of non-protein-bound platinum, which can be removed by dialysis, play an important role in the antitumor effects and ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000170256

    authors: Yura T,Badr KF,Yuasa S,Kurose T,Ohkawa M,Hando T,Fukunaga M,Matsuo H

    更新日期:1996-01-01 00:00:00

  • Impact of acute renal failure on the relationship between N-terminal pro-B-type natriuretic peptide and hemodynamic parameters.

    abstract:BACKGROUND:We studied the influence of acute renal failure (ARF) on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hemodynamic parameters. METHODS:The echocardiographic parameters and NT-proBNP levels were compared between 26 mechanically ventilated patients with ARF requiring conti...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322259

    authors: Balik M,Jabor A,Otahal M,Waldauf P,Pavlisova M

    更新日期:2011-01-01 00:00:00

  • Strategies for the Super-Aged Dialysis Population: Survival Benefits or Alternative Goals?

    abstract:BACKGROUND/AIMS:Japan's aging population has prominent epidemiological and patient characteristics. The number of hemodialysis patients aged ≥70 years is increasing. Age-adjusted mortality is improving, but some cause-specific mortalities remain unchanged, including infectious disease and malignancy, requiring combativ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000496660

    authors: Sakurai S,Hanafusa N,Nomura T,Tsuchiya K,Nitta K,Nangaku M

    更新日期:2019-01-01 00:00:00

  • Plasma Biomarkers in Predicting Renal Recovery from Acute Kidney Injury in Critically Ill Patients.

    abstract:BACKGROUND:Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. OBJECTIVES:To validate p...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000500423

    authors: Fiorentino M,Tohme FA,Murugan R,Kellum JA

    更新日期:2019-01-01 00:00:00

  • Electrocardiographic changes during hemodiafiltration with different potassium removal rates.

    abstract:BACKGROUND/AIMS:Sudden K removal is thought to be implicated in ECG alterations observed during hemodialysis (HD). The effects of the K removal rate on ECG-derived parameters have been investigated. METHODS:Two different hemodiafiltration (HDF) schedules were used for 10 HD patients: the dialysate K concentration was ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000073440

    authors: Severi S,Vecchietti S,Cavalcanti S,Mancini E,Santoro A

    更新日期:2003-01-01 00:00:00

  • Anticoagulation of diethyl citrate and its comparison with sodium citrate in an animal model.

    abstract:AIMS:To improve the side effects caused by sodium citrate (Na(3)Cit), the anticoagulant effects of diethyl citrate (Et(2)Cit) were investigated. METHODS:The in vitro anticoagulant effects and dissociation capacity of the chelate of Et(2)Cit with calcium ions were compared with those of Na(3)Cit in rabbits. RESULTS:Th...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000330891

    authors: Chen Z,Chen B,Yao XQ,Gui BS,Ou Y,Ouyang JM

    更新日期:2012-01-01 00:00:00

  • Hepatitis C: who should you treat and how?

    abstract::At present the treatment of hepatitis C virus infection (HCV) has improved because of combined treatment with interferon (IFN) and ribavirin. The association of these two drugs has obtained a positive response in 40-50% of naive patients treated. Patients with relapse after monotherapy with IFN also show positive resp...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000046996

    authors: Sánchez Tapias JM,Rodés J

    更新日期:2002-01-01 00:00:00

  • Determinants of N-terminal pro-brain natriuretic peptide variation in hemodialysis patients and prediction of survival.

    abstract:BACKGROUND/AIMS:N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000360267

    authors: Snaedal S,Qureshi AR,Carrero JJ,Heimbürger O,Stenvinkel P,Bárány P

    更新日期:2014-01-01 00:00:00