Organ cross talk in the critically ill: the heart and kidney.

Abstract:

:Heart failure results in significant morbidity and mortality in the United States. Chronic heart failure is often complicated by renal insufficiency. Further, acute decompensated heart failure is often complicated by worsening renal function or the development of diuretic resistance. Heart failure complicated by renal dysfunction has a significantly worse prognosis. The pathophysiology underlying this so-called cardiorenal syndrome (CRS) is unclear. It likely involves a combination of maladaptive neurohormonal activation and renal homeostatic mechanisms. The treatment (including recombinant B-type natriuretic peptide, ultrafiltration, continuous furosemide infusions and vasopressin antagonists) has thus far been marginally successful at best. Further research into the mechanism and treatment of CRS is required.

journal_name

Blood Purif

journal_title

Blood purification

authors

Kociol R,Rogers J,Shaw A

doi

10.1159/000207198

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

311-20

issue

4

eissn

0253-5068

issn

1421-9735

pii

000207198

journal_volume

27

pub_type

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