Abstract:
BACKGROUND/AIMS:Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of several genes involved in CKD and PD disease mechanisms. The aim of this work was to investigate the association between polymorphisms in the VDR gene and end-stage renal disease (ESRD) and PD. METHODS:222 subjects with and without ESRD (in hemodialysis) were divided into groups with and without PD. Polymorphisms TaqI and BsmI in the VDR gene were analyzed by PCR restriction fragment length polymorphism. The significance of differences in allele, genotype and haplotype frequencies between groups was assessed by the chi2 test (p value <0.05) and odds ratio (OR). RESULTS:Allele G was associated with protection against ESRD: groups without versus with ESRD (GG) x (GA+AA): OR = 2.5, 95% CI = 1.4-4.6, p = 0.00; (G x A): OR = 1.5, 95% CI = 1.0-2.3, p = 0.02; (TG + CG) x (TA + CA): OR = 1.5, 95% CI = 1.0-2.3, p = 0.02. No association was observed between the study polymorphisms and susceptibility to or protection against PD. CONCLUSION:Allele G of the VDR BsmI polymorphism was associated with protection against ESRD.
journal_name
Blood Purifjournal_title
Blood purificationauthors
de Souza CM,Braosi AP,Luczyszyn SM,Avila AR,de Brito RB Jr,Ignácio SA,Probst CM,Riella MC,Sotomaior VS,Mira MT,Pecoits-Filho R,Trevilatto PCdoi
10.1159/000109235subject
Has Abstractpub_date
2007-01-01 00:00:00pages
411-9issue
5-6eissn
0253-5068issn
1421-9735pii
000109235journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Bioelectrical impedance analysis (BIA) is a promising technique to evaluate dry weight. We compared the dry weight calculated by the three BIA equations Carlo Basile (CB) , Yanna Dou (YD) and the body composition spectroscopy (BCS) with clinical evaluation in maintenance hemodialysis (MHD) patients. METHODS...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000362109
更新日期:2014-01-01 00:00:00
abstract::A new plate dialyzer, Gambro PRO-3, with a polycarbonate-polyether membrane (Gambrane) was tested. The membrane thickness is 16 micron and the dialyzer surface area 0.77 m2. 11 regular hemodialysis patients who were treated 3 times per week were studied and 32 dialyses were performed. Clearances of urea, creatinine, u...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169426
更新日期:1986-01-01 00:00:00
abstract::The factors involved in choosing a treatment modality for the infant, child and adolescent with endstage renal disease (ESRD) are different than those utilized when counseling an adult patient. Age at the time ESRD develops, mental status, psychosocial status and the primary renal disease must be taken into considerat...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169450
更新日期:1987-01-01 00:00:00
abstract::The effects of pulsatile perfusion on microcirculation and renal function in high-risk patients were evaluated in this study. Pulsatile roller pumps with a pulsatile control module and membrane oxygenator were used in a clinical setting. 40 patients undergoing elective cardiac surgery with a high risk of either having...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Recent advances in nanotechnology have made it possible to mass-produce ultrathin silicon membranes with pore sizes in the range of nanometers. In this study, we investigate the possibility of employing ultrathin nanoporous silicon membranes with pore diameters of 5 and 20 nm for dialysis of human whole...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000350613
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Glycated hemoglobin is used to assess diabetic control although its accuracy in dialysis has been questioned. How does it compare to the Continuous Glucose Monitoring System (CGMS) in peritoneal dialysis (PD) patients? METHODS:We conducted a retrospective analysis of 60 insulin-treated diabetic patients o...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000439242
更新日期:2016-01-01 00:00:00
abstract::Recently, a new type of modified cellulosic membrane (Hemophan) has been made available for the first clinical trials. In contrast to cellulose acetate membranes only about 5% of the hydroxyl groups of cellulose are substituted by tertiary amino groups. Objective of the present study was to assess the compatibility pe...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169475
更新日期:1987-01-01 00:00:00
abstract:AIMS:To improve the side effects caused by sodium citrate (Na(3)Cit), the anticoagulant effects of diethyl citrate (Et(2)Cit) were investigated. METHODS:The in vitro anticoagulant effects and dissociation capacity of the chelate of Et(2)Cit with calcium ions were compared with those of Na(3)Cit in rabbits. RESULTS:Th...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000330891
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Despite the progression of dialysis techniques, the mortality of hemodialysis (HD) patients is still high in China. Here, a retrospective study was performed to investigate the neglected risk factors of all-cause mortality during maintenance HD (MHD). METHODS:We investigated 117 MHD patients who died betwe...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000497269
更新日期:2019-01-01 00:00:00
abstract::Although cis-diamminedichloroplatinum (cisplatin) is widely used in the treatment of malignant tumors, the dose administered is limited because of side effects such as nephrotoxicity. The plasma levels of non-protein-bound platinum, which can be removed by dialysis, play an important role in the antitumor effects and ...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000170256
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS:Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RES...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000487223
更新日期:2018-01-01 00:00:00
abstract::Several strategies have been proposed to increase dialysis efficiency in order to reduce dialysis treatment time. Paired filtration dialysis (two-chamber technique) is a new technique combining the advantages of highly permeable membranes and convective transport with the high depurative efficacy of diffusion. The sys...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169955
更新日期:1990-01-01 00:00:00
abstract::The biological processes governing vascular endothelial cell health are complex and highly redundant. The mechanisms involved in cell injury and repair remain an area of intense study. This paper attempts to review current knowledge regarding hormones such as vitamin D, erythropoietin and aldosterone within the contex...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000089436
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Fluid balance disorders are a relevant risk factor for morbidity and mortality in critically ill patients. Volume assessment in the intensive care unit (ICU) is thus of great importance, but there are currently few methods to obtain an accurate and timely assessment of hydration status. Our aim was to evalua...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000356366
更新日期:2013-01-01 00:00:00
abstract::Severe hypertriglyceridemia (HTG) is associated with acute pancreatitis (AP). Treatment options include total plasma exchange (TPE). We report a case of AP due to severe HTG treated with TPE. ...
journal_title:Blood purification
pub_type:
doi:10.1159/000510647
更新日期:2020-11-24 00:00:00
abstract::The number of geriatric patients on dialysis is increasing. This is due to demographic factors, a wider acceptance of elderly patients on dialysis, and an earlier start of dialysis in this patient group. Recent studies have questioned the effect of dialysis on quality of life in elderly patients with severe comorbidit...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000334153
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Anemia is a major complication of end-stage renal disease. Hemodialysis itself is regarded as a stimulus activating inflammation. Pro-inflammatory cytokines are able to suppress erythropoiesis. In this pilot study, we analyzed the changes in methylation status of promoters of immune response genes in cell-fr...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000356094
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. OBJECTIVES:To validate p...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000500423
更新日期:2019-01-01 00:00:00
abstract::Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinem...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000470827
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The mortality rate of peritoneal dialysis (PD) patients is still high and controversies persist regarding the mortality predictor. This study was designed to identify the predictability of the extracellular water/intracellular water ratio (E/I) on mortality in PD patients. METHODS:227 incident PD patients w...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000101699
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The coronavirus disease 2019 (COVID-19) pandemic led to increased demand nationwide for dialysis equipment, including supplies and machines. To meet the demand in our institution, our surge plan included rapid mobilization of a novel continuous renal replacement treatment (CRRT) machine named SAMI. The SAM...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000511726
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Satisfactory and noninvasive diagnostic tools for coronary artery disease (CAD) are not available in hemodialysis patients. We aimed to elucidate a reliable tool to diagnose CAD in these patients. METHODS:102 hemodialysis patients received 2D speckle-tracking echocardiography with left ventricular (LV) stra...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000323536
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Increased serum levels of proinflammatory cytokines may contribute to the organ damage in active antineutrophil cytoplasmic antigen (ANCA)-positive renal vasculitis. Plasma exchange (PE) may influence the activity of vasculitis not only by removing pathogenic autoantibodies, but also by lowering the serum le...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014316
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Asymmetric dimethylarginine (ADMA) levels are increased in hemodialysis (HD) patients. Reports on the effect of various dialysis strategies on ADMA, symmetric dimethylarginine (SDMA) and L-arginine levels are inconclusive. PATIENTS/METHODS:In this randomized crossover study, 15 patients were dialyzed for 4 ...
journal_title:Blood purification
pub_type: 杂志文章,随机对照试验
doi:10.1159/000104868
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. METHODS:We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multice...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000485231
更新日期:2018-01-01 00:00:00
abstract::Malnutrition, which is common in maintenance hemodialysis (HD) patients, is strongly associated with increased morbidity and mortality. Protein requirements in HD patients are increased twice or more compared to those of healthy subjects. Underdialysis leads to anorexia with low protein and energy intake in relation t...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170072
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Hypertension affects almost all chronic kidney disease patients and is related to poor outcomes. Sodium intake is closely related to blood pressure (BP) levels in this population and decreasing its intake consistently improves the BP control particularly in short-term controlled trials. However, most patient...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000485154
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed to examine the association between daily protein intake (DPI) and outcomes in patients from the Randomized Evaluation of Normal versus Augmented Level (RENAL) trial. METHODS:We analyzed the association between DPI and clinical outcomes using multivariable logistic regression, Cox proportio...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000363175
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIM:Haemodialysis-treated patients are at a high risk of developing cardiovascular disease. Part of this risk may be attributable to the type of the dialysis membrane used. We evaluated whether different dialysis membranes differ with respect to platelet activation. METHODS:In a randomized crossover trial, ...
journal_title:Blood purification
pub_type: 杂志文章,随机对照试验
doi:10.1159/000108628
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:To identify factors of health-related quality of life (HRQOL) of Chinese end-stage renal disease patients undergoing hemodialysis (HD). METHODS:In all, 315 HD patients were recruited from a tertiary hospital in Suzhou, -China. Each patient completed the Kidney Disease Quality of Life Short Form. It generate...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000485962
更新日期:2018-01-01 00:00:00