Cytokine secretion and markers of inflammation in relation to acidosis among chronic hemodialysis patients.

Abstract:

BACKGROUND:Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measure pro- and anti-inflammatory cytokines in HD patients, with relation to bicarbonate levels. METHODS:Forty-seven stable HD patients were included (male/female 28/19, mean age 70.4 ± 14.5 years). Blood tests were taken before a midweek dialysis session. Cytokine secretion from peripheral blood mononuclear cells was measured. RESULTS:Acidosis versus no acidosis (serum HCO3 – 21.5 ± 0.2 vs. 24.9 ± 0.3 mEq/l, p < 0.001) was associated with decreased secretion of the anti-inflammatory interleukin-10 (IL-10, 1.16 ± 0.11 vs. 1.71 ± 0.20 ng/ml, p = 0.023). Patients with acidosis had higher parathyroid hormone (PTH), calcium-phosphate product, protein intake and transferrin. Higher IL-10 was associated with increased IL-6 secretion, higher bicarbonate, younger age and lower PTH. CONCLUSIONS:In stable chronic HD patients, a possible direct relation exists between metabolic acidosis and IL-10.

journal_name

Blood Purif

journal_title

Blood purification

authors

Ori Y,Bergman M,Bessler H,Zingerman B,Levy-Drummer RS,Gafter U,Salman H

doi

10.1159/000346689

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

181-6

issue

1-3

eissn

0253-5068

issn

1421-9735

journal_volume

35

pub_type

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