Abstract:
BACKGROUND:Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measure pro- and anti-inflammatory cytokines in HD patients, with relation to bicarbonate levels. METHODS:Forty-seven stable HD patients were included (male/female 28/19, mean age 70.4 ± 14.5 years). Blood tests were taken before a midweek dialysis session. Cytokine secretion from peripheral blood mononuclear cells was measured. RESULTS:Acidosis versus no acidosis (serum HCO3 – 21.5 ± 0.2 vs. 24.9 ± 0.3 mEq/l, p < 0.001) was associated with decreased secretion of the anti-inflammatory interleukin-10 (IL-10, 1.16 ± 0.11 vs. 1.71 ± 0.20 ng/ml, p = 0.023). Patients with acidosis had higher parathyroid hormone (PTH), calcium-phosphate product, protein intake and transferrin. Higher IL-10 was associated with increased IL-6 secretion, higher bicarbonate, younger age and lower PTH. CONCLUSIONS:In stable chronic HD patients, a possible direct relation exists between metabolic acidosis and IL-10.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Ori Y,Bergman M,Bessler H,Zingerman B,Levy-Drummer RS,Gafter U,Salman Hdoi
10.1159/000346689subject
Has Abstractpub_date
2013-01-01 00:00:00pages
181-6issue
1-3eissn
0253-5068issn
1421-9735journal_volume
35pub_type
杂志文章abstract::Guidelines have been developed in nephrology and medicine developed to assist practitioners and patients in making decisions about healthcare for specific clinical circumstances. There has been a proliferation of guidelines over the last decade in all areas of medicine, including nephrology. Many of the nephrology gui...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000110568
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journal_title:Blood purification
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pub_type: 临床试验,杂志文章,评审
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pub_type: 杂志文章
doi:10.1159/000337101
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000437410
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更新日期:1996-01-01 00:00:00
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journal_title:Blood purification
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pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000500423
更新日期:2019-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000452755
更新日期:2016-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000046958
更新日期:2001-01-01 00:00:00
abstract::On-line hemodiafiltration (ol-HDF) may improve clinical outcome in ESRD. The supposed mechanism is the improved clearance of uremic toxins by convective transport which is added to the diffusion transport. However, recent marked improvement in the performance of dialyzers has allowed higher removal rate of middle to l...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000346217
更新日期:2013-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000245650
更新日期:2010-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169976
更新日期:1990-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170201
更新日期:1995-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169411
更新日期:1985-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169475
更新日期:1987-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章,评审
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000227282
更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Blood purification
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