Implementation of a Simplified Regional Citrate Anticoagulation Protocol for Post-Dilution Continuous Hemofiltration Using a Bicarbonate Buffered, Calcium Containing Replacement Solution.

Abstract:

BACKGROUND/AIMS:Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a citrate source. Our objective was to demonstrate that the protocol was safe and effective. METHODS:Prospective audit of consecutive patients receiving RCA for CRRT within intensive care unit, who were either contraindicated to heparin or had poor filter lifespan (<12 h for 2 consecutive filters) on heparin. RESULTS:We present the first 29 patients who used 98 filters. After excluding 'non-clot' filter loss, 50% had a duration of >27 h. Calcium supplementation was required for 30 (30%) filter circuits, in 17 of 29 (58%) patients. One patient discontinued the treatment due to metabolic alkalosis, but there were no adverse bleeding events. CONCLUSION:Post-dilution RCA system is effective and simple to use on the Aquarius platform and results in comparable filter life for patients relatively contraindicated to heparin.

journal_name

Blood Purif

journal_title

Blood purification

authors

Kirwan CJ,Hutchison R,Ghabina S,Schwarze S,Beane A,Ramsay S,Thompson E,Prowle JR

doi

10.1159/000452755

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

349-355

issue

4

eissn

0253-5068

issn

1421-9735

pii

000452755

journal_volume

42

pub_type

杂志文章
  • C-reactive protein in end-stage renal disease: are there reasons to measure it?

    abstract::Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this population, inflammation (a common phenomenon in ESRD), and other non-traditional ri...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000082014

    authors: Stenvinkel P,Lindholm B

    更新日期:2005-01-01 00:00:00

  • Enhanced biocompatibility with a new cellulosic membrane: Cuprophan versus Hemophan.

    abstract::Recently, a new type of modified cellulosic membrane (Hemophan) has been made available for the first clinical trials. In contrast to cellulose acetate membranes only about 5% of the hydroxyl groups of cellulose are substituted by tertiary amino groups. Objective of the present study was to assess the compatibility pe...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169475

    authors: Schaefer RM,Hörl WH,Kokot K,Heidland A

    更新日期:1987-01-01 00:00:00

  • Haemodialysis fluid: composition and clinical importance.

    abstract::Dialysis fluid is produced by the blending of treated water with electrolytes at the patients bed side. Its preparation and composition are important elements of treatment optimisation since many of the constituents play a role in patient well-being. Ideally the composition of the dialysis fluid should match that of p...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000096400

    authors: Hoenich NA,Ronco C

    更新日期:2007-01-01 00:00:00

  • Enhanced functional performance characteristics of a new polysulfone membrane for high-flux hemodialysis.

    abstract::Elimination of uremic solutes with molecular weights up to 60 kD, without significant loss of albumin is an important therapeutic goal to optimize outcomes in chronic hemodialysis patients. To characterize a newly developed polysulfone dialyzer (APS-650) a comparative analysis was performed with a highly advanced poly...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000063099

    authors: Klingel R,Ahrenholz P,Schwarting A,Röckel A

    更新日期:2002-01-01 00:00:00

  • Red blood cell density distribution in uremic patients on acetate and bicarbonate hemodialysis.

    abstract::Renal anemia is the result of reduced erythropoietin (EPO) biosynthesis in the diseased kidney and also in part the result of a reduced life span of red blood cells (RBCs). An increase in density and a decrease in enzyme equipment (aspartate aminotransferase; GOT) of RBCs reflect cell age. In the following study, the ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169976

    authors: Hampl H,Riedel E,Wendel G,Scigalla P

    更新日期:1990-01-01 00:00:00

  • Novel insights into the pathobiology of the vascular access - do they translate into improved care?

    abstract::While recent developments have allowed greater insight into the vascular pathobiology and intimal hyperplasia, very few of these advances have led to improved clinical care of hemodialysis vascular accesses. Indeed the most common procedure for the treatment of access stenosis and thrombosis is the same model for the ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000245650

    authors: Diskin CJ

    更新日期:2010-01-01 00:00:00

  • A 15-year-old girl with severe hemolytic Wilson's crisis recovered without transplantation after extracorporeal circulation with the Prometheus system.

    abstract:BACKGROUND:Wilson's disease (WD) can present in a fulminant form with hepatocellular dysfunction, hemolysis and multiorgan failure (Wilson's crisis). We present a previously healthy young woman with severe WD whose WD severity score was 13. A score >11 indicates a poor chance of survival and liver transplantation will ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000218090

    authors: Aagaard NK,Thomsen KL,Holland-Fischer P,Jørgensen SP,Ott P

    更新日期:2009-01-01 00:00:00

  • Benefit of glucose-free dialysis solutions on glucose and lipid metabolism in peritoneal dialysis patients.

    abstract:BACKGROUND:Glucose absorbed from conventional peritoneal dialysis (PD) solutions contributes to unfavorable metabolic effects. Its replacement with a glucose-free osmotic agent such as icodextrin (ID) or amino acids (AA) may have some benefit on glucose and lipid metabolism. METHODS:Serum lipids, insulin sensitivity a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000086553

    authors: Martikainen T,Teppo AM,Gronhagen-Riska C,Ekstrand A

    更新日期:2005-01-01 00:00:00

  • Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population.

    abstract:BACKGROUND:Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. METHODS:We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multice...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000485231

    authors: Mitsides N,Cornelis T,Broers NJH,Diederen NMP,Brenchley P,van der Sande FM,Schalkwijk C,Kooman JP,Mitra S

    更新日期:2018-01-01 00:00:00

  • Impact of acute renal failure on the relationship between N-terminal pro-B-type natriuretic peptide and hemodynamic parameters.

    abstract:BACKGROUND:We studied the influence of acute renal failure (ARF) on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hemodynamic parameters. METHODS:The echocardiographic parameters and NT-proBNP levels were compared between 26 mechanically ventilated patients with ARF requiring conti...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000322259

    authors: Balik M,Jabor A,Otahal M,Waldauf P,Pavlisova M

    更新日期:2011-01-01 00:00:00

  • Leveraging Big Data and Electronic Health Records to Enhance Novel Approaches to Acute Kidney Injury Research and Care.

    abstract::While acute kidney injury (AKI) has been poorly defined historically, a decade of effort has culminated in a standardized, consensus definition. In parallel, electronic health records (EHRs) have been adopted with greater regularity, clinical informatics approaches have been refined, and the field of EHR-enabled care ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000458751

    authors: Sutherland SM,Goldstein SL,Bagshaw SM

    更新日期:2017-01-01 00:00:00

  • Improvement of anemia in patients on chronic dialysis treated by hemodiafiltration.

    abstract::A group of patients with severe anemia on standard hemodialysis were transferred to polyacrylnitrile hemodiafiltration (HDF), which was arranged in order to obtain an ultrafiltration rate (UF) higher than 100 ml/min. During HDF, despite a significant reduction of the dialysis time, all patients had a significant decre...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169591

    authors: Gonella M,Pratesi G,Calabrese G,Vagelli G,Mazzotta A

    更新日期:1989-01-01 00:00:00

  • Effects of Multidisciplinary Team Care Based on 5E's Renal Rehabilitation for Peritoneal Dialysis Patients in Guangxi Zhuang Autonomous Region of China: A Randomized Controlled Trial.

    abstract:BACKGROUND:The number of patients with peritoneal dialysis (PD) in China has been increasing year after year, but there are still some challenge in the management of PD patients, and the efficient and effective method has yet to be developed. Multidisciplinary team (MDT) is to create a standardized, individualized, and...

    journal_title:Blood purification

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000496823

    authors: Luo Y,Huang Y,Chen X,Meng G,Zhang Y

    更新日期:2019-01-01 00:00:00

  • Anorexia and malnutrition in hemodialysis patients.

    abstract::Malnutrition, which is common in maintenance hemodialysis (HD) patients, is strongly associated with increased morbidity and mortality. Protein requirements in HD patients are increased twice or more compared to those of healthy subjects. Underdialysis leads to anorexia with low protein and energy intake in relation t...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000170072

    authors: Bergström J

    更新日期:1992-01-01 00:00:00

  • Antioxidant enzymes--superoxide dismutase and glutathione peroxidase--in haemodialyzed patients.

    abstract::The biological effect of oxygen-reactive species controlled by antioxidant mechanisms are exerted on the basis of antioxidant enzymes and substrates. In this study, the activities of antioxidant enzymes-superoxide dismutase (SOD) and glutathione peroxidase (GPx)-were determined in the erythrocytes of patients on regul...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170269

    authors: Zima T,Stípek S,Crkovská J,Nĕmecek K,Pláteník J,Bártová V,Tesar V

    更新日期:1996-01-01 00:00:00

  • Alleviation of cisplatin nephrotoxicity: efficacy of local intra-arterial injection concomitant with hemodialysis.

    abstract::Although cis-diamminedichloroplatinum (cisplatin) is widely used in the treatment of malignant tumors, the dose administered is limited because of side effects such as nephrotoxicity. The plasma levels of non-protein-bound platinum, which can be removed by dialysis, play an important role in the antitumor effects and ...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000170256

    authors: Yura T,Badr KF,Yuasa S,Kurose T,Ohkawa M,Hando T,Fukunaga M,Matsuo H

    更新日期:1996-01-01 00:00:00

  • Anticoagulation of diethyl citrate and its comparison with sodium citrate in an animal model.

    abstract:AIMS:To improve the side effects caused by sodium citrate (Na(3)Cit), the anticoagulant effects of diethyl citrate (Et(2)Cit) were investigated. METHODS:The in vitro anticoagulant effects and dissociation capacity of the chelate of Et(2)Cit with calcium ions were compared with those of Na(3)Cit in rabbits. RESULTS:Th...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000330891

    authors: Chen Z,Chen B,Yao XQ,Gui BS,Ou Y,Ouyang JM

    更新日期:2012-01-01 00:00:00

  • Calculating Standard Kt/V during Hemodialysis Based on Urea Mass Removed.

    abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000493178

    authors: Leypoldt JK,Vonesh EF

    更新日期:2019-01-01 00:00:00

  • Dialysate Calcium Levels: Do They Matter?

    abstract:BACKGROUND:Calcium (Ca) is an essential element that plays a critical role in many biological processes. In dialysis patients, the regulation of Ca balance is highly complex, given the absence of kidney function, endocrine disturbances and the use of drugs such as phosphate binders, vitamin D analogues, and calcimimeti...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000494584

    authors: van der Sande FM,Ter Meulen KJA,Kotanko P,Kooman JP

    更新日期:2019-01-01 00:00:00

  • Predialysis systolic blood pressure evolution in incident hemodialysis patients: effects of the dry weight method and prognostic value.

    abstract:BACKGROUND:The relationship between predialysis blood pressure (BP) and hemodialysis (HD) patient outcomes is controversial. We report the evolution of predialysis BP in incident patients treated with the dry weight method and its relationship with patients' outcomes. METHODS:Between January 2000 and 2009, 308 patient...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000337101

    authors: Chazot C,Vo-Van C,Deleaval P,Lorriaux C,Hurot JM,Mayor B,Jean G

    更新日期:2012-01-01 00:00:00

  • Body Fluids in End-Stage Renal Disease: Statics and Dynamics.

    abstract:BACKGROUND:Abnormalities in fluid status in hemodialysis (HD) patients are highly prevalent and are related to adverse outcomes. SUMMARY:The inherent discontinuity of the HD procedure in combination with an often compromised cardiovascular response is a major contributor to this phenomenon. In addition, systemic infla...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000494583

    authors: Kooman JP,van der Sande FM

    更新日期:2019-01-01 00:00:00

  • Is There Enough Evidence to Prove That Hemodiafiltration Is Superior?

    abstract::The evidence concerning online hemodiafiltration (HDF) includes the following: (1) the increase of removal of uremic toxin, (2) the prevention of dialysis rerated hypotension, (3) the recovery of survival, and (4) the recovery of dialysis related uncertain symptoms. Although clinical evidence has been noted, the hypot...

    journal_title:Blood purification

    pub_type: 社论

    doi:10.1159/000487917

    authors: Kawanishi H

    更新日期:2018-01-01 00:00:00

  • Psychological aspects of low protein diet therapy.

    abstract::One of the main problems in low protein diet is patient's noncompliance and the risk of both depression and reduced quality of life. A pilot study investigated the life-style and the state of mood before and during low protein diet. The results show a deterioration in the life-style and the state of mood. Conclusions ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169572

    authors: Haeberle KN

    更新日期:1989-01-01 00:00:00

  • Amino acids and keto acids in the treatment of chronic renal failure.

    abstract::Clinical trials using very low protein supply supplemented with amino acid or keto acid preparations have shown the possibility of slowing the rate of decline of renal function in patients with advanced chronic renal failure together with preservation of nutritional status. The possible mechanisms by which this effect...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,评审

    doi:10.1159/000169557

    authors: Jungers P,Chauveau P

    更新日期:1988-01-01 00:00:00

  • Impact of a genetic polymorphism of the interleukin-1 receptor antagonist on technique survival in peritoneal dialysis patients.

    abstract:BACKGROUND/AIMS:There is a clear association between one allele of the interleukin-1 receptor-antagonist gene (IL-1RN) and inflammatory diseases in which IL-1 is implicated. We evaluated patient survival and technique survival of peritoneal dialysis (PD) patients, while analyzing independent risk factors, in a PD progr...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000088988

    authors: Uchiyama K,Naito K,Tsuchida M,Takai K,Okayama N,Fujimura K,Hinoda Y

    更新日期:2005-01-01 00:00:00

  • Cytokines and biocompatibility.

    abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

  • Failure of naloxone in reversal hemodialysis-induced hypotension.

    abstract::In 5 uremic patients the role of opioid peptides in dialysis-induced hypotension was investigated through the administration of naloxone. An intravenous bolus injection of 1 mg of naloxone was administered immediately before starting a routine hemodialysis session and was repeated when the patients' systolic arterial ...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169411

    authors: Sturani A,Degli Esposti E,Chiarini C,Spongano M,Santoro A,Zucchelli P

    更新日期:1985-01-01 00:00:00

  • Effect of Sedative-Hypnotic Medicines on Mortality in Peritoneal Dialysis Patients with Sleep Disorders: A Retrospective Cohort Study.

    abstract:BACKGROUND:Sedative-hypnotic medication is widely used among continuous ambulatory peritoneal dialysis (CAPD) patients with sleep disorders; however, its effect on mortality has rarely been investigated. METHODS:Logistic regression was employed to identify factors associated with sedative-hypnotic medication, whose ef...

    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

    doi:10.1159/000484922

    authors: Zhou Y,Yin P,Li B,Li J,Huang N,Wu H,Ullah H,Yang X,Yu X

    更新日期:2018-01-01 00:00:00

  • Intradialytic body weight changes and dialyzer pore size as main contributing factors to the evolution of beta-2-microglobulin in dialysis.

    abstract::Cuprophane hemodialysis is associated with an early fall of leukocyte counts and an intradialytic rise in serum beta 2-microglobulin (beta 2M), in contrast to dialysis with more compatible dialyzers. It has been suggested that these two phenomena may be related. This study sets out to verify this hypothesis by compari...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169922

    authors: Vanholder RC,Ringoir SM

    更新日期:1990-01-01 00:00:00

  • Initiation Condition of Hemodialysis Is Independently Associated with All-Cause Mortality in Maintenance Hemodialysis Patients: A Retrospective Study.

    abstract:BACKGROUND:Despite the progression of dialysis techniques,  the mortality of hemodialysis (HD) patients is still high in China. Here, a retrospective study was performed to investigate the neglected risk factors of all-cause mortality during maintenance HD (MHD). METHODS:We investigated 117 MHD patients who died betwe...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000497269

    authors: Wang C,Yang Y,Yuan F,Li HQ,He LY,Liu D,Liu YX,Zhou A,Chen X,Liu FY,Peng YM,Liu H

    更新日期:2019-01-01 00:00:00