Cardiovascular and Patient Phenotype of Extended Haemodialysis: A Critical Analysis of Studying a Unique Patient Population.

Abstract:

BACKGROUND:Extended haemodialysis (EHD) has been associated with better outcomes compared to conventional (CHD) regimes. The cardiovascular (CV) profile of these patients has not been assessed in detail. METHODS:We report baseline demographic and CV phenotype of 36 CHD and 36 EHD participants to a longitudinal multicentre study. We measured pulse wave velocity (PWV), 24-h ambulatory blood pressure, sublingual dark-field capillaroscopy and vascular biomarkers. RESULTS:EHD patients were younger (p < 0.01), with less CV comorbidity (p = 0.04) and higher dialysis vintage (p < 0.01). Higher PWV in CHD (p = 0.02) was not independent of demographic differences in the 2 groups. Biomarker profiles were similar in EHD and CHD but abnormal compared to healthy controls. CONCLUSION:Although CV profiles in these 2 cohorts were similar, EHD patients were distinct from the CHD population in terms of age and dialysis vintage and appear to comprise a unique group. Direct comparison of outcomes in these groups is challenging due to clinical bias.

journal_name

Blood Purif

journal_title

Blood purification

authors

Mitsides N,Cornelis T,Broers NJH,Diederen NMP,Brenchley P,van der Sande FM,Schalkwijk C,Kooman JP,Mitra S

doi

10.1159/000485231

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

356-363

issue

4

eissn

0253-5068

issn

1421-9735

pii

000485231

journal_volume

45

pub_type

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