Abstract:
PURPOSE:This study was aimed at evaluating the efficacy and safety of regional citrate anticoagulation (RCA) versus no-anticoagulation continuous venovenous hemofiltration (CVVH) in acute severe hypernatremia patients with increased bleeding risk. MATERIALS AND METHODS:Acute severe hypernatremia patients with high bleeding risk who underwent CVVH in our center between January 2011 and October 2017 were considered as candidates. Patients who were <18 years old, with hypovolemic hypernatremia, and had systemic anticoagulation were excluded. The included patients were divided into RCA and no-anticoagulation groups according to their anticoagulation strategy during CVVH and matched by age, sequential organ failure assessment scores, and vasopressor dependency. RESULTS:Of the 64 included patients, no-anticoagulation and RCA were employed for CVVH in 23 and 41 patients, respectively. The serum sodium reduction rate (RRSeNa) was not significantly different between the no-anticoagulation and RCA groups (p = 0.729). Compared to no-anticoagulation, RCA significantly prolonged the circuit survival time (15 h [4.1-23.9] vs. 51 h [21.3-80.7], p = 0.001). The incidence of filter failure was 65.2% (15/23) in the no-anticoagulation group and 2.4% (1/41) in the RCA group (p < 0.001), respectively. In the matched cohort, the RRSeNas were not different between the 2 groups (p = 0.569), and the filter lifespan was significantly longer in the RCA group as well (p < 0.001). CONCLUSION:RCA might be safe and effective for acute severe hypernatremia patients who underwent CVVH treatment. Further prospective, randomized, control trials are warranted to obtain robust evidences.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Zhao L,Ma F,Yu Y,Li Y,Wang Y,He L,Zhou M,Tian X,Jing R,Li L,Li L,Huang C,Bai M,Sun Sdoi
10.1159/000502937subject
Has Abstractpub_date
2020-01-01 00:00:00pages
44-54issue
1-2eissn
0253-5068issn
1421-9735pii
000502937journal_volume
49pub_type
临床试验,杂志文章abstract::In previous reports of the Frequent Hemodialysis Network trials, frequent hemodialysis (HD) reduced extracellular fluid (ECF) and left ventricular mass (LVM), with more pronounced effects observed among patients with low urine volume (UVol). We analyzed the effect of frequent HD on interdialytic weight gain (IDWG) and...
journal_title:Blood purification
pub_type: 杂志文章,随机对照试验
doi:10.1159/000441966
更新日期:2016-01-01 00:00:00
abstract::Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical condition...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000360520
更新日期:2014-01-01 00:00:00
abstract::Dialysis dependence at hospital discharge after acute kidney injury (AKI) requiring renal replacement therapy (RRT) in the intensive care unit (ICU) is found in 10-15% of survivors. In case of severe AKI in the ICU, it is necessary to reconcile two objectives: the creation of an adequate temporary angioaccess for RRT ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000341721
更新日期:2012-01-01 00:00:00
abstract::Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinem...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000470827
更新日期:2017-01-01 00:00:00
abstract::Contradictory data are reported in the literature concerning the diffusion kinetics of inorganic phosphates (iPh) between red blood cells and plasma during haemodialysis. Accordingly, we performed mass balance and equilibration studies to analyze the diffusion kinetics of iPh in vivo and in vitro. Mass balance analysi...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014470
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000493178
更新日期:2019-01-01 00:00:00
abstract::The EUPHRATES trial (Evaluating Use of Polymyxin B Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemia and Septic Shock) is the first biomarker-driven trial in sepsis. This unique trial is being run in a blinded manner, further contributing to the robustness of its design. This paper will ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000356832
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000338923
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We explored whether biocompatible dialyzer membranes modulate the inflammatory response during blood contact in patients with systemic inflammation. METHODS:15 patients with end-stage renal disease and systemic inflammation (mean serum C-reactive protein 86 +/- 4 mg/l) were randomly treated with Cuprophan (...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000083941
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Fluid balance disorders are a relevant risk factor for morbidity and mortality in critically ill patients. Volume assessment in the intensive care unit (ICU) is thus of great importance, but there are currently few methods to obtain an accurate and timely assessment of hydration status. Our aim was to evalua...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000356366
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Interleukin-10 (IL-10), a potent regulatory monokine produced by activated mononuclear cells, provides an efficient autocrine mechanism for controlling proinflammatory cytokine synthesis. We hypothesized that defective synthesis of IL-10 could contribute to the inflammatory state in hemodialysis (HD) patient...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000066958
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Calcium loading has been associated with cardiovascular risk in hemodialysis (HD) patients. However, it remains to be elucidated whether alterations of intradialytic calcium buffering add to the increased cardiovascular disease burden in this high-risk population. METHODS:Intradialytic calcium kin...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000508060
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:We studied the influence of acute renal failure (ARF) on the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and hemodynamic parameters. METHODS:The echocardiographic parameters and NT-proBNP levels were compared between 26 mechanically ventilated patients with ARF requiring conti...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000322259
更新日期:2011-01-01 00:00:00
abstract::The number of geriatric patients on dialysis is increasing. This is due to demographic factors, a wider acceptance of elderly patients on dialysis, and an earlier start of dialysis in this patient group. Recent studies have questioned the effect of dialysis on quality of life in elderly patients with severe comorbidit...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000334153
更新日期:2012-01-01 00:00:00
abstract::Kidney transplantation (KT) is considered an optimal treatment strategy for end-stage renal disease. But human leukocyte antigen-sensitized, ABO-incompatible and antibody-mediated rejection might be the alarming hurdles in KT. Therapeutic plasma exchange is the mainstay of the antibody reduction therapy for reducing a...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000493521
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND AIM:Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). Management of hypercholesterolemia consists of drug therapies, including statins and proprotein convertase subtilisin/kexin type 9 inhibitors. In patients with familial hy...
journal_title:Blood purification
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000497447
更新日期:2019-01-01 00:00:00
abstract::The low water permeability feature of original cellulosic membranes was considered an advantage in the absence of dialysis equipment that are capable of controlling water removal. The advent of ultrafiltration control systems led to the development and use of high-flux (HF) membranes that allowed improved middle molec...
journal_title:Blood purification
pub_type: 社论
doi:10.1159/000476012
更新日期:2017-01-01 00:00:00
abstract:AIMS:To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis. METHODS:A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful kid...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000157373
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Increasing evidence suggests that clinical signs of periodontal disease are independently associated with renal impairment. However, no studies have examined the possible linkage of kidney disease with serum antibody to oral pathogens. METHODS:The periodontal disease status was assessed in an older com...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000096411
更新日期:2007-01-01 00:00:00
abstract::Pathophysiological aspects of plasma volume preservation and cardiovascular reactivity are reviewed, comparing combined ultrafiltration-hemodialysis with isolated ultrafiltration and hemofiltration. The role of different factors in the disparity in cardiovascular reactivity between these treatments is discussed. ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170294
更新日期:1996-01-01 00:00:00
abstract::The greatest benefit of PD ist the continuous maintenance of a stable electrolyte and acid-base balance, as well as a continuous solute, sodium and water removal. Moreover, PD is effective in preserving residual renal function (RRF). However, when RRF declines, complications will occur if not compensated for by an inc...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000081871
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:Dialysis membrane has been implicated in selenium (Se) deficiency in hemodialysis (HD). Intradialytic Se removal into dialysate through different membranes was investigated. METHODS:We studied 19 patients on standard HD with low-flux polysulfone membrane (group A), 10 patients on standard HD with ethyl...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000441438
更新日期:2016-01-01 00:00:00
abstract::We report the clinical course of 29 patients with Wegener's granulomatosis (WG) treated with plasma exchange (PE) in Norway in the period from 1988 to 1999. Median follow-up was 41.5 months. The mean number of exchanges was 8.5 +/- 5.8 (range 2-32). Median serum creatinine concentration was 400 micromol/l (range 90-1,...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000047004
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:We have reported that vitamin D deficiency may be implicated in the pathogenesis of hypoalbuminemia observed in patients with end-stage renal disease, but the mechanism remains to be clarified. The aim of the present study was to determine whether supplementation with alfacalcidol might increase protein inta...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000076855
更新日期:2004-01-01 00:00:00
abstract::Guidelines have been developed in nephrology and medicine developed to assist practitioners and patients in making decisions about healthcare for specific clinical circumstances. There has been a proliferation of guidelines over the last decade in all areas of medicine, including nephrology. Many of the nephrology gui...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000110568
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Wilson's disease (WD) can present in a fulminant form with hepatocellular dysfunction, hemolysis and multiorgan failure (Wilson's crisis). We present a previously healthy young woman with severe WD whose WD severity score was 13. A score >11 indicates a poor chance of survival and liver transplantation will ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000218090
更新日期:2009-01-01 00:00:00
abstract::Dialysis fluid produced by state-of-the-art water preparation and distribution is contaminated with gram-negative bacteria and cytokine-inducing substances (CIS) derived from these microorganisms. The presence of a biofilm increases the risk of continuous contamination of dialysis fluid. Depending on the type of dialy...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000074932
更新日期:2004-01-01 00:00:00
abstract::Renal anemia is the result of reduced erythropoietin (EPO) biosynthesis in the diseased kidney and also in part the result of a reduced life span of red blood cells (RBCs). An increase in density and a decrease in enzyme equipment (aspartate aminotransferase; GOT) of RBCs reflect cell age. In the following study, the ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169976
更新日期:1990-01-01 00:00:00
abstract::The central dialysis fluid delivery system (CDDS) has been working exclusively in Japan since 1970, a fact which proves that CDDS is useful in the multi-patient treatment with in-center regular hemodialysis. It is a cost-effective, labor-saving and time-tested system with 40 years of experience. Microbial safety is im...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000213494
更新日期:2009-01-01 00:00:00
abstract::The factors involved in choosing a treatment modality for the infant, child and adolescent with endstage renal disease (ESRD) are different than those utilized when counseling an adult patient. Age at the time ESRD develops, mental status, psychosocial status and the primary renal disease must be taken into considerat...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169450
更新日期:1987-01-01 00:00:00