Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient during COVID-19 Pandemic: Expert Review and Recommendation.

Abstract:

:Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. Based on pathophysiological derangements observed in COVID-19 patients, a rationale emerges for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ systems. In the absence of vaccines or direct therapy for COVID-19, extracorporeal therapies could represent an option to prevent organ failure and improve survival. The enormous demand in care for COVID-19 patients requires an immediate response from the scientific community. Thus, a detailed review of the available technology is provided by experts followed by a series of recommendation based on current experience and opinions, while waiting for generation of robust evidence from trials.

journal_name

Blood Purif

journal_title

Blood purification

authors

Ronco C,Bagshaw SM,Bellomo R,Clark WR,Husain-Syed F,Kellum JA,Ricci Z,Rimmelé T,Reis T,Ostermann M

doi

10.1159/000508125

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

17-27

issue

1

eissn

0253-5068

issn

1421-9735

pii

000508125

journal_volume

50

pub_type

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