Abstract:
BACKGROUND/AIMS:Intravenous iron infusion is the accepted way of supplementation of that compound in uremic patients. The aim of the study was to evaluate whether this treatment affects intraperitoneal homeostasis in patients on peritoneal dialysis. METHODS:Blood and peritoneal dialysate samples were collected from 10 patients treated with continuous ambulatory peritoneal dialysis who were given 100 mg iron sucrose (IS) intravenously. Systemic and peritoneal permeability as well as transperitoneal transport were studied. The effect of spent dialysate was tested in vitro on human peritoneal mesothelial cells (MCs). RESULTS:Dialysate total iron was increased (+19%, p < 0.01) during intravenous infusion of IS. Immediately after infusion the concentration of 8-OHdG was increased in plasma (+10%, p < 0.01) and in dialysate (+5%, p < 0.05). IS infusion caused a transient decrease in peritoneal permeability to protein (-42%, p < 0.05) and glucose (-30%, p < 0.01) and a reduction in dialysate cell count (-58%, p < 0.05). During the exchange dialysate hyaluronan was increased by 27% (p < 0.01). Spent dialysate, tested ex vivo on cultured MC, induced oxidative stress (+39%, p < 0.01), slowed their proliferation (-20%, p < 0.01), and stimulated MCP-1 synthesis (+46%, p < 0.01). Iron content in MCs exposed to dialysate obtained after IS infusion was increased by 32% (p < 0.01). CONCLUSION:Intravenous infusion of IS causes oxidative stress and inflammation within peritoneal MCs which may impair viability of the peritoneum.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Breborowicz A,Połubinska A,Kupczyk M,Wanic-Kossowka M,Oreopoulos DGdoi
10.1159/000210038subject
Has Abstractpub_date
2009-01-01 00:00:00pages
53-8issue
1eissn
0253-5068issn
1421-9735pii
000210038journal_volume
28pub_type
杂志文章abstract:AIMS:To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis. METHODS:A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful kid...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000157373
更新日期:2008-01-01 00:00:00
abstract::Cuprophane hemodialysis is associated with an early fall of leukocyte counts and an intradialytic rise in serum beta 2-microglobulin (beta 2M), in contrast to dialysis with more compatible dialyzers. It has been suggested that these two phenomena may be related. This study sets out to verify this hypothesis by compari...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169922
更新日期:1990-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000170153
更新日期:1994-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000113009
更新日期:2007-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000470827
更新日期:2017-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000197561
更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000083941
更新日期:2005-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000508125
更新日期:2021-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000363175
更新日期:2014-01-01 00:00:00
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journal_title:Blood purification
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170041
更新日期:1992-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014353
更新日期:1998-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170294
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:The relationship between heart rate variability (HRV) and residual renal function (RRF) has not been elucidated previously. METHODS:In this cross-sectional study, HRV was evaluated in 71 peritoneal dialysis patients. Patients were divided into RRF decline group, RRF stable group and anuric group. RESULTS:R...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000338184
更新日期:2012-01-01 00:00:00
abstract::At present the treatment of hepatitis C virus infection (HCV) has improved because of combined treatment with interferon (IFN) and ribavirin. The association of these two drugs has obtained a positive response in 40-50% of naive patients treated. Patients with relapse after monotherapy with IFN also show positive resp...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000046996
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:N-Terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor of cardiac events and death in the general population and in chronic kidney disease. There is limited information on how natriuretic peptides vary in dialysis patients. The aim of this study was to analyze NT-proBNP variability, factors...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000360267
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Psychological depression and physical disability are closely correlated in hemodialysis patients. A retrospective cohort study was conducted to examine the independent association of physical and psychological functioning with mortality in a hemodialysis cohort in Taiwan. METHODS:A total of 888 stable hemod...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000319002
更新日期:2010-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000330891
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIM:The relationship between body mass index (BMI) and intradialytic hypotension (IDH) has been inconsistently reported, but no further research has investigated the correlation between body composition and IDH so far. This study aimed to determine whether the lean tissue index (LTI), fat tissue index (FTI),...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000504245
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Carpal tunnel syndrome (CTS) is a common clinical presentation of dialysis-related amyloidosis. It was determined whether β(2)-microglobulin (β2M) and advanced glycation end products in serum are predictors of CTS in dialysis patients. METHODS:A total of 385 hemodialysis patients were screened for CTS....
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000338923
更新日期:2012-01-01 00:00:00
abstract::Conventional treatment of acute and chronic renal diseases has focused on solute removal. Novel strategies aim to treat the multifactorial disease states of acute kidney injury and chronic kidney disease by mitigating inflammation. Cell-based technologies for the treatment of kidney dysfunction fall under two broad ca...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000341649
更新日期:2012-01-01 00:00:00
abstract::For maintenance hemodialysis (MHD) patients, the blood is in low hypercoagulable state due to the use of heparin or low molecular weight heparin during dialysis. It is not rare to see hematoma in the puncture site. In recent years, several cases have been reported of spontaneous kidney rupture, but no hip hematoma, le...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000446177
更新日期:2016-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000439242
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cardiovascular diseases (CVD) are the leading cause of mortality in hemodialysis (HD) patients. Recently, non-alcoholic fatty liver disease (NAFLD) has been recognized as a new risk factor for adverse CVD events in the general population. Our aim was to analyze the incidence of NAFLD in HD patients by u...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000360270
更新日期:2014-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000381006
更新日期:2015-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000209250
更新日期:2009-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000503678
更新日期:2020-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000368980
更新日期:2015-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000485590
更新日期:2018-01-01 00:00:00