Ex vivo Rezafungin Adsorption and Clearance During Continuous Renal Replacement Therapy.

Abstract:

BACKGROUND/AIMS:To determine adsorption and transmembrane clearances (CLTM) of rezafungin, a novel long-acting echinocandin, in continuous venovenous hemofiltration (CVVH). METHODS:A validated ex vivo bovine blood CVVH model using polysulfone and AN69 hemodiafilters was used to evaluate urea and rezafungin CLTM at 3 different ultrafiltrate flow rates. Rezafungin adsorption to the CRRT apparatus was determined for each hemodiafilter. RESULTS:The sieving coefficient (SC) from CVVH with 3 different ultrafiltrate flow rates was 0 for both HF1400 and Multiflow-150 hemodiafilters, while urea SC was approximately 1 at all flow rates. Hemodiafilter type and ultrafiltrate flow rate did not influence CLTM. Rezafungin adsorption to the CVVH apparatus was not observed for either hemodiafilter. CONCLUSION:Rezafungin is not removed by CVVH by membrane adsorption or via CLTM. Ultrafiltrate flow rates and hemodiafilter types are unlikely to influence rezafungin CLTM. No dosage adjustment of rezafungin is likely required for critically ill patients receiving CVVH.

journal_name

Blood Purif

journal_title

Blood purification

authors

Jang SM,Hough G,Mueller BA

doi

10.1159/000489212

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

214-219

issue

3

eissn

0253-5068

issn

1421-9735

pii

000489212

journal_volume

46

pub_type

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