Plasma dimethylarginine levels in chronic hemodialysis patients are independent of the type of dialyzer applied.

Abstract:

BACKGROUND:Asymmetric dimethylarginine (ADMA) levels are increased in hemodialysis (HD) patients. Reports on the effect of various dialysis strategies on ADMA, symmetric dimethylarginine (SDMA) and L-arginine levels are inconclusive. PATIENTS/METHODS:In this randomized crossover study, 15 patients were dialyzed for 4 weeks with 4 dialyzers, differing in biocompatibility and flux. Dimethylarginine and L-arginine levels were assessed at baseline, and after 4 weeks both before and after HD. RESULTS:During HD, ADMA and SDMA levels decreased significantly with all dialyzers. Dimethylarginine and L-arginine levels remained stable after 4 weeks of HD with each membrane. After pooling all data, values were mainly explained by variation between time points and patients, not by the type of dialyzer. CONCLUSION:Despite an intradialytic decrease in dimethylarginines, no changes occurred after 4 weeks of HD with either membrane. Furthermore, the variability of AMDA, SDMA and L-arginine levels was far more dependent on patient-related factors than on the type of dialyzer applied.

journal_name

Blood Purif

journal_title

Blood purification

authors

Grooteman MP,Wauters IM,Teerlink T,Twisk JW,Nubé MJ

doi

10.1159/000104868

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

281-9

issue

3

eissn

0253-5068

issn

1421-9735

pii

000104868

journal_volume

25

pub_type

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