Therapeutic Plasma Exchange in Neonates and Infants: Successful Use of a Miniaturized Machine.

Abstract:

:Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinemia being the most notable exception. The only alternative to TPE in small pediatric patients is manual blood exchange transfusion, which, however, bears an unacceptably high risk of severe complications. Still, technical issues due to extracorporeal circulation in neonates have burdened TPE so far, since machines developed for adults require a relatively large blood volume to operate. We in this study, describe our preliminary experience of TPE for treating 2 potentially life-threatening conditions in neonatal age. To overcome the aforementioned limitations, plasmapheresis was performed in both cases using a machine specifically designed for patients weighing less than 10 kg.

journal_name

Blood Purif

journal_title

Blood purification

authors

Vidal E,Garzotto F,Parolin M,Manenti C,Zanin A,Bellettato M,Remuzzi G,Goldstein SL,Murer L,Ronco C

doi

10.1159/000470827

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

100-105

issue

2

eissn

0253-5068

issn

1421-9735

pii

000470827

journal_volume

44

pub_type

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