Factors predicting erythropoietin resistance among maintenance hemodialysis patients.

Abstract:

BACKGROUND:Erythropoiesis-stimulating agent (ESA) resistance remains incompletely understood among hemodialysis (HD) patients. METHOD:A retrospective, multicenter study was designed to analyze data from 1,934 patients followed for up to two years. The outcome measure was the erythropoietin resistance index (ERI), defined as erythropoietin dosage over a week divided by the post-HD weight and hemoglobin value. RESULTS:Multivariate analysis revealed albumin, Kt/V, transferrin saturation, statin use and male gender to be inversely related to ERI, whereas parathyroid hormone and angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB) use were associated with higher ESA resistance. ERI was statistically lower in patients with higher levels of albumin (p < 0.001) and with higher transferrin saturation levels (p < 0.05). DISCUSSION:The results allow for a better understanding of predictors of erythropoietin resistance among HD patients including not extensively studied factors such as statin and ACEI/ARB use.

journal_name

Blood Purif

journal_title

Blood purification

authors

Mallick S,Rafiroiu A,Kanthety R,Iqbal S,Malik R,Rahman M

doi

10.1159/000335256

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

238-44

issue

4

eissn

0253-5068

issn

1421-9735

pii

000335256

journal_volume

33

pub_type

临床试验,杂志文章,多中心研究
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    authors: Gutierrez A,Alvestrand A,Bergström J,Beving H,Lantz B,Henderson LW

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    更新日期:2016-01-01 00:00:00

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    更新日期:1987-01-01 00:00:00

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    authors: Bowry SK,Gatti E

    更新日期:2011-01-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:2003-01-01 00:00:00

  • Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient during COVID-19 Pandemic: Expert Review and Recommendation.

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    journal_title:Blood purification

    pub_type: 杂志文章,评审

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    authors: Ronco C,Bagshaw SM,Bellomo R,Clark WR,Husain-Syed F,Kellum JA,Ricci Z,Rimmelé T,Reis T,Ostermann M

    更新日期:2021-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000014470

    authors: Descombes E,Jutzet A,Perriard F,Fellay G

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    pub_type: 杂志文章

    doi:10.1159/000169591

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    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000169987

    authors: Davenport A,Will EJ,Davison AM

    更新日期:1990-01-01 00:00:00

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    journal_title:Blood purification

    pub_type: 临床试验,杂志文章,随机对照试验

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    journal_title:Blood purification

    pub_type: 临床试验,杂志文章

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    更新日期:2003-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Peraldi MN,Berrou J,Métivier F,Toubert A

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    pub_type: 杂志文章,评审

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    authors: Cerda J,Sheinfeld G,Ronco C

    更新日期:2010-01-01 00:00:00

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000210038

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    更新日期:2009-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

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    更新日期:2018-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1159/000083941

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    更新日期:2005-01-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2006-01-01 00:00:00

  • Trace elements in end-stage renal disease. 1. Methodological aspects and the influence of water treatment and dialysis equipment.

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    pub_type: 杂志文章,评审

    doi:10.1159/000014394

    authors: Zima T,Tesar V,Mestek O,Nemecek K

    更新日期:1999-01-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:2001-01-01 00:00:00

  • Angiotensin Converting Enzyme Inhibitor Dialyzability and Outcomes in Older Patients Receiving Hemodialysis.

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    doi:10.1159/000345186

    authors: Bonilla-Félix M

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  • Therapeutic Plasma Exchange in Neonates and Infants: Successful Use of a Miniaturized Machine.

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    authors: Vidal E,Garzotto F,Parolin M,Manenti C,Zanin A,Bellettato M,Remuzzi G,Goldstein SL,Murer L,Ronco C

    更新日期:2017-01-01 00:00:00