Abstract:
:The effects of pulsatile perfusion on microcirculation and renal function in high-risk patients were evaluated in this study. Pulsatile roller pumps with a pulsatile control module and membrane oxygenator were used in a clinical setting. 40 patients undergoing elective cardiac surgery with a high risk of either having chronically obstructive pulmonary disease or chronic renal failure were randomly included in the study to be perfused using pulsatile or continuous flows. Blood samples were collected at induction of anesthesia, at the time of aortic clamping and declamping and 1 and 24 h following cessation of the bypass. Urea and creatinine concentrations in blood were measured and systemic vascular resistance was calculated. Urine output, crystalloid and colloid infusions were recorded. We observed that pulsatile roller pump perfusion and the extracorporeal circuit used in the clinical study improved microcirculation and renal function in high-risk patients undergoing cardiopulmonary bypass.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Kocakulak M,Aşkin G,Kuçukaksu S,Tarcan O,Pişkin Edoi
10.1159/000085174subject
Has Abstractpub_date
2005-01-01 00:00:00pages
263-7issue
4eissn
0253-5068issn
1421-9735pii
85174journal_volume
23pub_type
临床试验,杂志文章,随机对照试验abstract::In hemodialysis patients, C-reactive protein (CRP), an acute-phase reactant, is a sensitive and independent marker of malnutrition, anemia, and amyloidosis. The aim of the present studies was to evaluate CRP and interleukin 6 levels in plasma samples from long-term hemodialysis patients on different extracorporeal mod...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000014405
更新日期:2000-01-01 00:00:00
abstract::Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this population, inflammation (a common phenomenon in ESRD), and other non-traditional ri...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000082014
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. OBJECTIVES:To validate p...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000500423
更新日期:2019-01-01 00:00:00
abstract::Backgound: This study was aimed at evaluating the presepsin and procalcitonin levels to predict adverse postoperative complications and mortality in cardiac surgery patients. METHODS:A total of 122 cardiac surgery patients were enrolled for the study. Presepsin and procalcitonin levels were measured 48 h after the pr...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000494207
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality i...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000366124
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:We estimated the flow of endotoxins (ET) from dialysates into the blood of patients on hemodialysis (HD) using limulus amebocyte lysate (LAL) assays and endotoxin activity (EA) determined by neutrophil respiratory burst activity. METHODS:A cross-sectional study compared groups given ultrapure bicarbonate (n...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000322622
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:In this study, we focused on whether volume overload plays a role in the development of arterial stiffness. METHODS:Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was as...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000199432
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measur...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000346689
更新日期:2013-01-01 00:00:00
abstract::To reduce the potential occurrence of hypotension during a dialysis treatment, intermittent infusion hemodiafiltration (I-HDF) using back filtration with an ultrapure dialysis fluid was developed. Under typical I-HDF treatment conditions, some 200-300 ml of ultrapure dialysis fluid was infused into the blood component...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000346371
更新日期:2013-01-01 00:00:00
abstract::In 5 uremic patients the role of opioid peptides in dialysis-induced hypotension was investigated through the administration of naloxone. An intravenous bolus injection of 1 mg of naloxone was administered immediately before starting a routine hemodialysis session and was repeated when the patients' systolic arterial ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169411
更新日期:1985-01-01 00:00:00
abstract::Doubt has remained as to whether or not the K/DOQI recommended targets for adequacy of dialysis for peritoneal dialysis patients is appropriate (weekly Kt/V 2 + creatinine clearance 50-60 l/1.73 m(2)). The ADEMEX trial can be interpreted as indicating that lower targets might be acceptable. The HEMO trial, not yet pub...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000067869
更新日期:2003-01-01 00:00:00
abstract::Optimal iron level in hemodialysis patients remains a subject of debate. The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow. CHr is not influenced by any factors that measure direct hemoglobin (Hb) of reticulocytes and...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000496641
更新日期:2019-01-01 00:00:00
abstract::Activation of polymorphonuclear leukocytes with subsequent production of reactive oxygen metabolites has been reported to occur during hemodialysis related to a membrane bioincompatibility. We used an experimental dialysis model to evaluate, by chemiluminescence, the production of reactive oxygen metabolites and, by C...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169604
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The relationship between predialysis blood pressure (BP) and hemodialysis (HD) patient outcomes is controversial. We report the evolution of predialysis BP in incident patients treated with the dry weight method and its relationship with patients' outcomes. METHODS:Between January 2000 and 2009, 308 patient...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000337101
更新日期:2012-01-01 00:00:00
abstract::A group of patients with severe anemia on standard hemodialysis were transferred to polyacrylnitrile hemodiafiltration (HDF), which was arranged in order to obtain an ultrafiltration rate (UF) higher than 100 ml/min. During HDF, despite a significant reduction of the dialysis time, all patients had a significant decre...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169591
更新日期:1989-01-01 00:00:00
abstract::In patients with chronic kidney disease (CKD), peptides and proteins circulate at altered concentrations versus in healthy individuals. We have characterized proteome samples from 7 pooled CKD stage 5 patients not yet on dialysis and with no known co-morbidities. We also analyzed pooled plasma samples from 7 healthy a...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000178773
更新日期:2008-01-01 00:00:00
abstract::Heart failure (HF) is a chronic disease process associated with significant morbidity and mortality. Hospitalizations for acute decompensation may be frequent and herald a downward trajectory for the underlying disease state and overall poor prognosis for the patient. While significant advances have been made in the r...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000110558
更新日期:2008-01-01 00:00:00
abstract::There is a wide variability in the utilization of peritoneal dialysis throughout Europe that cannot be explained by differences in medical factors alone. Over the last years, the utilization of peritoneal dialysis has even changed in individual countries. The main factors of this variation are not medical, but rather ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000089446
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed to examine the association between daily protein intake (DPI) and outcomes in patients from the Randomized Evaluation of Normal versus Augmented Level (RENAL) trial. METHODS:We analyzed the association between DPI and clinical outcomes using multivariable logistic regression, Cox proportio...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000363175
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:We derived a novel equation for calculating weekly urea standard Kt/V (stdKt/V) during hemodialysis (HD) based on urea mass removed, comparable to the approach during peritoneal dialysis. METHODS:Theoretical consideration of urea mass balance during HD led to the following equation for stdKt/V, namely,...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000493178
更新日期:2019-01-01 00:00:00
abstract::During the past few years, it has become increasingly evident that residual renal function (RRF) is an important and independent predictor of poor outcome in patients with chronic kidney disease (CKD). Although the causes of this observation are not fully understood, it appears that the loss of RRF impairs both fluid ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000078699
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Intradialytic hypotension (IDH) is a major challenge to safely performing haemodialysis. Blood volume depletion due to fluid removal is a major cause of hypotension, so more emphasis should be placed on finding alternative modalities to traditional constant rate ultrafiltration. SUMMARY:Intermittent back-fi...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000503878
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000230812
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Hemoadsorption may improve outcomes for sepsis by removing circulating cytokines. We tested a new sorbent used for hemoadsorption. METHODS:CTR sorbent beads were filled into columns of three sizes: CTR0.5 (0.5 ml), CTR1 (1.0 ml) and CTR2 (2.0 ml) and tested using IL-6 capture in vitro. Next, rats were ...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000381006
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine adsorption and transmembrane clearances (CLTM) of rezafungin, a novel long-acting echinocandin, in continuous venovenous hemofiltration (CVVH). METHODS:A validated ex vivo bovine blood CVVH model using polysulfone and AN69 hemodiafilters was used to evaluate urea and rezafungin CLTM at 3 d...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000489212
更新日期:2018-01-01 00:00:00
abstract::Peritoneal transport rates, a critical determinant of peritoneal dialysis efficiency, vary widely among patients and may be easily categorized by standardized peritoneal equilibration test. Measurements of creatinine and glucose transfer are particularly useful in selecting optimal dialysis prescription. Patients with...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000169582
更新日期:1989-01-01 00:00:00
abstract::Fluid overload may occur in critically ill patients as a result of aggressive resuscitation therapies. In such circumstances, persistent fluid overload must be avoided since it does not benefit the patient while it may be harmful. In the septic patient, early volume expansion seems to be beneficial. Beyond that thresh...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000287776
更新日期:2010-01-01 00:00:00
abstract::Dialysis fluid is produced by the blending of treated water with electrolytes at the patients bed side. Its preparation and composition are important elements of treatment optimisation since many of the constituents play a role in patient well-being. Ideally the composition of the dialysis fluid should match that of p...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000096400
更新日期:2007-01-01 00:00:00
abstract::While the optimal vascular conduit for hemodialysis is undeniably an arterialized autogenous subcutaneous vein, only a minority of end-stage renal disease patients can count on such access: the remainder require implantation of a biomaterial conduit. This paper will briefly survey current biografts used for hemodialys...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170148
更新日期:1994-01-01 00:00:00
abstract::Haemodialysis is associated with increased oxidant stress. This appears to be due to (1) an increased production of free radicals during haemodialysis, (2) a net reduction of many antioxidants and (3) factors intrinsic to the uremic state. These alterations can lead to cardiovascular disease and many of the pathologie...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000014384
更新日期:1999-01-01 00:00:00