Changes in circulating levels of calcitonin gene-related peptide and nitric oxide metabolites in septic patients during direct hemoperfusion with polymyxin B-immobilized fiber.

Abstract:

BACKGROUND/AIMS:This study evaluated the mechanism of hemodynamic improvement in polymyxin B-immobilized fiber (PMX) treatment. METHODS:Fifteen septic patients with endotoxemia and/or gram negative infection were treated with PMX. Plasma concentrations of calcitonin gene-related peptide (CGRP) and nitric oxide metabolites were measured. RESULTS:CGRP and nitric oxide metabolites before treatment were significantly higher than in healthy controls. CGRP had a significantly inverse correlation with diastolic blood pressure and a positive correlation with the Septic Severity Score and the number of failed organs. Systolic and diastolic blood pressure and systemic vascular resistance index increased significantly both immediately after and 24 h after PMX treatment. CGRP decreased significantly 24 h after the treatment. In contrast, there were no significant changes in nitric oxide metabolites. CONCLUSION:PMX treatment improved hemodynamic parameters in septic patients, and CGRP increased with increasing severity of sepsis. We conclude that a decrease in CGRP levels may be related to hemodynamic improvement resulting from PMX treatments.

journal_name

Blood Purif

journal_title

Blood purification

authors

Shimizu T,Hanasawa K,Tani T,Endo Y,Kurumi Y,Ikeda T,Fujita N,Morita H,Imaizumi H,Sato T,Katayama H

doi

10.1159/000070696

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

237-43

issue

3

eissn

0253-5068

issn

1421-9735

pii

70696

journal_volume

21

pub_type

临床试验,杂志文章
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  • Clinical investigation of the new dialyzer Gambro PRO-3.

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    更新日期:1986-01-01 00:00:00

  • Net ultrafiltration in peritoneal dialysis: role of direct fluid absorption into peritoneal tissue.

    abstract::'Net ultrafiltration' in peritoneal dialysis refers to the difference between the osmotically induced ultrafiltration into the peritoneal cavity and the fluid loss from the cavity during dialysis. Recent research has demonstrated that, during a 3- to 4-hour experimental dialysis, 5-25% of the total fluid loss is via l...

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    doi:10.1159/000170041

    authors: Flessner MF

    更新日期:1992-01-01 00:00:00

  • Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock.

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000501512

    authors: Osawa EA,Cutuli SL,Bitker L,Canet E,Cioccari L,Iguchi N,Lankadeva YR,Eastwood GM,Evans RG,May CN,Bellomo R

    更新日期:2019-01-01 00:00:00

  • Psychological aspects of low protein diet therapy.

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169572

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    更新日期:1989-01-01 00:00:00

  • Management of acute decompensated heart failure: renal implications.

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    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000110558

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    更新日期:2008-01-01 00:00:00

  • Bioartificial kidney alters cytokine response and hemodynamics in endotoxin-challenged uremic animals.

    abstract::The mortality from sepsis complicated by renal failure remains extremely high despite the application of modern renal replacement therapy. This study investigated whether treatment with a bioartificial kidney consisting of a hemofilter in a continuous venovenous hemofiltration circuit (CVVH) with a cartridge containin...

    journal_title:Blood purification

    pub_type: 杂志文章

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    authors: Fissell WH,Dyke DB,Weitzel WF,Buffington DA,Westover AJ,MacKay SM,Gutierrez JM,Humes HD

    更新日期:2002-01-01 00:00:00

  • Serum levels of 5-s-cysteinyldopa are correlated with skin colors in hemodialysis patients but not in peritoneal dialysis patients.

    abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...

    journal_title:Blood purification

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000230812

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    更新日期:2009-01-01 00:00:00

  • Is Sclerostin Level Associated with Cardiovascular Diseases in Hemodialysis Patients?

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    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000487223

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    更新日期:2018-01-01 00:00:00

  • When should renal replacement therapy for acute kidney injury be initiated and discontinued?

    abstract:BACKGROUND:Critically ill patients with acute kidney injury (AKI) are at high risk for death and frequently require initiation of renal replacement therapy (RRT). There is wide variation in clinical practice on the indications for and timing of initiation and discontinuation of RRT. Numerous clinical and biochemical fa...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000157325

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    更新日期:2008-01-01 00:00:00

  • Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality?

    abstract::Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical condition...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

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    authors: Kanbay M,Solak Y,Gaipov A,Takir M,Weiner DE

    更新日期:2014-01-01 00:00:00

  • Adequacy of peritoneal dialysis--where are we going?

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    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000170201

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    更新日期:1995-01-01 00:00:00

  • Two-compartment model of cholesterol kinetics for establishment of treatment strategy of LDL apheresis in nephrotic hypercholesterolemia.

    abstract::Cholesterol kinetics in the time course after LDL apheresis using a dextran sulfate cellulose column was analyzed by adapting a two-compartment cholesterol kinetic model. Fifteen sets of serial serum cholesterol concentrations after LDL apheresis from 4 patients with drug-resistant nephrotic hypercholesterolemia due t...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000170180

    authors: Yashiro M,Muso E,Matsushima M,Nagura R,Sawanishi K,Sasayama S

    更新日期:1994-01-01 00:00:00

  • Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.

    abstract::Tranquilizers, analgetics and antidepressants are applied in different ranges in the treatment of patients on hemodialysis. Due to many different pharmacokinetic properties, no perfect rules for dosage in acute or chronic hemodialysis exist. Adequate applicable drugs without adaptation disregarding different states of...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000169404

    authors: Forycki Z,Martens F,Thalhofer S,Ibe K

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  • Intradialytic Calcium Kinetics and Cardiovascular Disease in Chronic Hemodialysis Patients.

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    journal_title:Blood purification

    pub_type: 杂志文章

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    authors: Pirklbauer M,Fuchs L,Heiss R,Ratschiller T,Mayer G

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  • Practice guidelines do improve patient outcomes: association or causation?

    abstract::Guidelines have been developed in nephrology and medicine developed to assist practitioners and patients in making decisions about healthcare for specific clinical circumstances. There has been a proliferation of guidelines over the last decade in all areas of medicine, including nephrology. Many of the nephrology gui...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000110568

    authors: Levin A

    更新日期:2008-01-01 00:00:00

  • Impact of hemodialysis therapy on anemia of chronic kidney disease: the potential mechanisms.

    abstract::A significant and increasing number of chronic kidney disease (CKD) patients are treated with online hemodiafiltration (OL-HDF), even in the absence of more conclusive survival data. OL-HDF affords several clinical benefits including control of anemia of CKD, a common affliction in dialysis patients. In efforts to und...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000329573

    authors: Bowry SK,Gatti E

    更新日期:2011-01-01 00:00:00

  • Dietary and pharmacological control of calcium and phosphate metabolism in dialysis patients.

    abstract::Chronic kidney disease-mineral and bone disorder is a new term defining a complex syndrome which underlines the need of a systemic approach to disturbances of calcium and phosphate metabolism in patients with renal failure. In recent years, the availability of new phosphorus binders and the appearance of new selective...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000209250

    authors: Bover J,Andrés E,Lloret MJ,Aguilar A,Ballarín J

    更新日期:2009-01-01 00:00:00

  • Severe Secondary Hyperparathyroidism in a Hemodialysis Patient: A Case Report from Mongolia.

    abstract::Secondary hyperparathyroidism (SHPT) occurs in patients with chronic renal failure complicated with renal bone disease and soft tissue/vascular calcification. In dialysis patients with severe SHPT, medical treatment may fail and parathyroidectomy (PTX) is indicated for definitive treatment. Severe hypocalcemia from hu...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000479616

    authors: Adiya S,Damdinsuren K,Dorj C

    更新日期:2017-01-01 00:00:00

  • Anorexia and malnutrition in hemodialysis patients.

    abstract::Malnutrition, which is common in maintenance hemodialysis (HD) patients, is strongly associated with increased morbidity and mortality. Protein requirements in HD patients are increased twice or more compared to those of healthy subjects. Underdialysis leads to anorexia with low protein and energy intake in relation t...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000170072

    authors: Bergström J

    更新日期:1992-01-01 00:00:00

  • Sodium Intake and Blood Pressure in Patients with Chronic Kidney Disease: A Salty Relationship.

    abstract:BACKGROUND:Hypertension affects almost all chronic kidney disease patients and is related to poor outcomes. Sodium intake is closely related to blood pressure (BP) levels in this population and decreasing its intake consistently improves the BP control particularly in short-term controlled trials. However, most patient...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000485154

    authors: Nerbass FB,Calice-Silva V,Pecoits-Filho R

    更新日期:2018-01-01 00:00:00

  • Intradialytic cytokine gene expression.

    abstract::Along with the numerous technological improvements in molecular biology, polymerase chain reaction, which permits analysis of sequences of a very small amount of biological material, enables evaluation of hemodialysis-induced gene transcription of inflammatory cytokines. Blood samples drawn from 22 hemodialysis patien...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000014310

    authors: Roccatello D,Menegatti E,Alfieri V,Rossi D,DeLuca A,Pignone E,Mengozzi G,Cesano G,Formica M,Martina G,Sena LM,Piccoli G

    更新日期:1998-01-01 00:00:00

  • Peritoneal Dialysis Treatment Modality Option in Acute Kidney Injury.

    abstract:BACKGROUND:Peritoneal dialysis (PD) may be a feasible and safe alternative to haemodialysis not only in the chronic but also in the acute setting. It was previously widely accepted as a modality for acute kidney injury (AKI) treatment, but its practice declined in favor of other types of extracorporeal therapies. SUMM...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000452703

    authors: Ponce D,Gobo-Oliveira M,Balbi AL

    更新日期:2017-01-01 00:00:00

  • Correlation between pulse wave velocity and fluid distribution in hemodialysis patients.

    abstract:BACKGROUND:In this study, we focused on whether volume overload plays a role in the development of arterial stiffness. METHODS:Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was as...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000199432

    authors: Zheng D,Cheng LT,Zhuang Z,Gu Y,Tang LJ,Wang T

    更新日期:2009-01-01 00:00:00

  • Finances of the independent dialysis facility.

    abstract::Medicare pays 80% of the cost of dialysis treatment and associated medications. Congress directed the Centers for Medicare and Medicaid Services (CMS) to develop both a process of regular and more or less "automatic" updates of composite rate setting and "bundling" as much of the laboratory and ancillary medications a...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000096390

    authors: DeOreo PB

    更新日期:2007-01-01 00:00:00

  • Effect of Early Cannulation with Plastic Cannula on Arteriovenous Fistula Patency in Hemodialysis Patients.

    abstract:INTRODUCTION:Plastic cannulas have been used to cannulate arteriovenous fistulas (AVFs) for hemodialysis (HD) in Japan for many years. However, the effect of early cannulation with plastic cannulas on AVF patency is not known. OBJECTIVE:We analyzed the relationship between first cannulation time (FCT) and patency rate...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000503678

    authors: Shi K,Jiang H,Wakabayashi M

    更新日期:2020-01-01 00:00:00

  • Cytokine secretion and markers of inflammation in relation to acidosis among chronic hemodialysis patients.

    abstract:BACKGROUND:Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measur...

    journal_title:Blood purification

    pub_type: 杂志文章

    doi:10.1159/000346689

    authors: Ori Y,Bergman M,Bessler H,Zingerman B,Levy-Drummer RS,Gafter U,Salman H

    更新日期:2013-01-01 00:00:00

  • Hemodynamic stability during different forms of dialysis therapy: a pathogenetic analysis.

    abstract::Pathophysiological aspects of plasma volume preservation and cardiovascular reactivity are reviewed, comparing combined ultrafiltration-hemodialysis with isolated ultrafiltration and hemofiltration. The role of different factors in the disparity in cardiovascular reactivity between these treatments is discussed. ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000170294

    authors: Hendrikus W,van Kuijk M,Leunissen KM

    更新日期:1996-01-01 00:00:00

  • Cytokines and biocompatibility.

    abstract::Issues in biocompatibility have traditionally focused on the interaction of membranes or materials with the activation of complement, red blood cell destruction, clotting dysfunctions, and platelet activation. Other studies are concerned with the replacement fluid formulations and host responses. Recent attention has ...

    journal_title:Blood purification

    pub_type: 杂志文章,评审

    doi:10.1159/000169968

    authors: Dinarello CA

    更新日期:1990-01-01 00:00:00

  • Antioxidant enzymes--superoxide dismutase and glutathione peroxidase--in haemodialyzed patients.

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    pub_type: 杂志文章

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    authors: Zima T,Stípek S,Crkovská J,Nĕmecek K,Pláteník J,Bártová V,Tesar V

    更新日期:1996-01-01 00:00:00