Abstract:
BACKGROUND:Omni® (B. Braun, Germany) is a new-generation, continuous renal replacement therapy (CRRT) machine designed to improve user interface, minimize downtime and optimize renal dose delivery. It was never tested in humans. METHODS:We used Omni® to provide CRRT in 10 critically ill patients. We collected therapy data, metabolic parameters and evaluated user's satisfaction with a survey. RESULTS:CRRT was delivered using Omni® in CVVH-heparin (6 patients) and CVVHD-citrate (4 patients) modes for a total duration of 617.7 h. No adverse event was observed. The mean filter life was 22.8 (CVVH-heparin) and 33.5 (CVVHD-citrate) h. Alarms-related downtime corresponded to 5.9% of total therapy time. Delivered renal dose was 96.6% of prescribed. Satisfactory metabolic control and fluid removal were achieved. Overall, users evaluated interface, design and usability as excellent. CONCLUSION:CRRT in CVVH-heparin and CVVHD-citrate modes was provided using Omni® in a safe and efficient way for 10 critically ill patients. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=451053.
journal_name
Blood Purifjournal_title
Blood purificationauthors
Schläpfer P,Durovray JD,Plouhinec V,Chiappa C,Bellomo R,Schneider Adoi
10.1159/000451053subject
Has Abstractpub_date
2017-01-01 00:00:00pages
11-17issue
1-3eissn
0253-5068issn
1421-9735pii
000451053journal_volume
43pub_type
杂志文章abstract::Hypertension is present in most patients with end-stage renal disease and likely contributes to the premature cardiovascular disease in dialysis patients. Previous practice guidelines have recommended that, in patients on chronic dialysis, blood pressure (BP) should be reduced below 130/80 mm Hg. This is based on opin...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000245631
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed to examine the association between daily protein intake (DPI) and outcomes in patients from the Randomized Evaluation of Normal versus Augmented Level (RENAL) trial. METHODS:We analyzed the association between DPI and clinical outcomes using multivariable logistic regression, Cox proportio...
journal_title:Blood purification
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000363175
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:We have reported that vitamin D deficiency may be implicated in the pathogenesis of hypoalbuminemia observed in patients with end-stage renal disease, but the mechanism remains to be clarified. The aim of the present study was to determine whether supplementation with alfacalcidol might increase protein inta...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000076855
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:Recent updates to the Nikkiso Aquarius continuous renal replacement therapy (CRRT) platform allowed us to develop a post-dilution protocol for regional citrate anticoagulation (RCA) using standard bicarbonate buffered, calcium containing replacement solution with acid citrate dextrose formula-A as a cit...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000452755
更新日期:2016-01-01 00:00:00
abstract::Tranquilizers, analgetics and antidepressants are applied in different ranges in the treatment of patients on hemodialysis. Due to many different pharmacokinetic properties, no perfect rules for dosage in acute or chronic hemodialysis exist. Adequate applicable drugs without adaptation disregarding different states of...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169404
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study evaluated the mechanism of hemodynamic improvement in polymyxin B-immobilized fiber (PMX) treatment. METHODS:Fifteen septic patients with endotoxemia and/or gram negative infection were treated with PMX. Plasma concentrations of calcitonin gene-related peptide (CGRP) and nitric oxide metabol...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000070696
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:This study was aimed at evaluating the efficacy and safety of regional citrate anticoagulation (RCA) versus no-anticoagulation continuous venovenous hemofiltration (CVVH) in acute severe hypernatremia patients with increased bleeding risk. MATERIALS AND METHODS:Acute severe hypernatremia patients with high ble...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000502937
更新日期:2020-01-01 00:00:00
abstract::Doubt has remained as to whether or not the K/DOQI recommended targets for adequacy of dialysis for peritoneal dialysis patients is appropriate (weekly Kt/V 2 + creatinine clearance 50-60 l/1.73 m(2)). The ADEMEX trial can be interpreted as indicating that lower targets might be acceptable. The HEMO trial, not yet pub...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000067869
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Increased serum levels of proinflammatory cytokines may contribute to the organ damage in active antineutrophil cytoplasmic antigen (ANCA)-positive renal vasculitis. Plasma exchange (PE) may influence the activity of vasculitis not only by removing pathogenic autoantibodies, but also by lowering the serum le...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014316
更新日期:1998-01-01 00:00:00
abstract::Effective dialysis therapy is now understood to encompass both small and large solute removal, using approaches that minimize intradialytic symptoms and maximize patient safety. Achieving the goal of providing effective dialysis for an expanding population of patients with increasingly complex medical problems at a ti...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000167001
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:In this study, we focused on whether volume overload plays a role in the development of arterial stiffness. METHODS:Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was as...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000199432
更新日期:2009-01-01 00:00:00
abstract::The low water permeability feature of original cellulosic membranes was considered an advantage in the absence of dialysis equipment that are capable of controlling water removal. The advent of ultrafiltration control systems led to the development and use of high-flux (HF) membranes that allowed improved middle molec...
journal_title:Blood purification
pub_type: 社论
doi:10.1159/000476012
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Oxidative stress has been considered a nontraditional risk factor for cardiovascular disease in the chronic kidney disease (CKD) population, possibly triggered by uremic toxicity. METHODS:A chromatographic method with coulometric detection was adapted to directly and simultaneously determine cysteine (...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000342627
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of severa...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000109235
更新日期:2007-01-01 00:00:00
abstract::To increase the efficiency of continuous arteriovenous hemofiltration (CAVH) in cases of severe catabolism, we used a modified CAVH treatment, called arteriovenous hemodiafiltration (AVHDF), in 4 patients. The transport of solutes was increased by providing the infusion of a counter current flow of urea-free solutions...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000169454
更新日期:1987-01-01 00:00:00
abstract::Numerous experimental and clinical studies suggest that uric acid might have pathobiologic implications in the development and progression of hypertension, kidney disease, and coronary heart disease, among others, resulting in renewed interest in uric acid as a potential pathogenic mediator in these clinical condition...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000360520
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Renal medullary hypoxia precedes the development of acute kidney injury in experimental sepsis and can now be assessed by continuous measurement of urinary oxygen tension (PuO2). OBJECTIVES:We aimed to test if PuO2 measurements in patients with septic shock would be similar to those shown in experimental se...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000501512
更新日期:2019-01-01 00:00:00
abstract::Pathophysiological aspects of plasma volume preservation and cardiovascular reactivity are reviewed, comparing combined ultrafiltration-hemodialysis with isolated ultrafiltration and hemofiltration. The role of different factors in the disparity in cardiovascular reactivity between these treatments is discussed. ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000170294
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Of 5 clinical trials testing dose response of continuous renal replacement therapy (CRRT) in acute kidney injury, 2 showed a benefit, 2 showed none, and 1 appeared equivocal. However, blood-membrane interactions may dominate macromolecule transport in continuous venovenous hemodiafiltration, reducing the imp...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000266483
更新日期:2010-01-01 00:00:00
abstract::A 50-year-old man with the rare McLeod syndrome, associated with glomerular lesion to the end stage of chronic renal failure and death, is reported. McLeod syndrome is an X-linked recessive disorder on the basis of abnormal expression of the Kell blood group antigens and absence of erythrocyte surface Kx antigen. Most...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000014353
更新日期:1998-01-01 00:00:00
abstract::Reprocessing of used dialyzers with chemical disinfectants is practiced commonly in the United States and in some areas of Western Europe. Concern over residual toxic or allergenic agents has encouraged the search for other practical methods to disinfect or sterilize used hemodialyzers. The use of moist heat has been ...
journal_title:Blood purification
pub_type:
doi:10.1159/000170132
更新日期:1993-01-01 00:00:00
abstract::Cholesterol kinetics in the time course after LDL apheresis using a dextran sulfate cellulose column was analyzed by adapting a two-compartment cholesterol kinetic model. Fifteen sets of serial serum cholesterol concentrations after LDL apheresis from 4 patients with drug-resistant nephrotic hypercholesterolemia due t...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000170180
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The incidence of central venous catheter-related bloodstream infection (CRBSI) for continuous renal replacement therapy (CRRT) in kidney intensive care unit (ICU) patients is worthy of particular attention and recently, we analyzed clinical characteristics and risk factors of CRBSI for CRRT in our kidney ICU...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000495024
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Diffuse hyperpigmentation is common in patients with chronic renal failure undergoing hemodialysis (HD) or peritoneal dialysis (PD). We previously reported that serum levels of 5-S-cysteinyldopa (5SCD, a pheomelanin precursor) and pheomelanin were significantly elevated in HD patients. METHODS:Skin color wa...
journal_title:Blood purification
pub_type: 杂志文章,多中心研究
doi:10.1159/000230812
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:It was recently reported that the severity of coronary and carotid atherosclerosis in patients with end-stage kidney disease (ESKD) has improved over the last two decades. However, the frequency of coronary artery events observed at the initiation of dialysis remains high. SUMMARY:Recently, 5 different clin...
journal_title:Blood purification
pub_type: 评论,杂志文章
doi:10.1159/000441582
更新日期:2015-01-01 00:00:00
abstract::Backgound: This study was aimed at evaluating the presepsin and procalcitonin levels to predict adverse postoperative complications and mortality in cardiac surgery patients. METHODS:A total of 122 cardiac surgery patients were enrolled for the study. Presepsin and procalcitonin levels were measured 48 h after the pr...
journal_title:Blood purification
pub_type: 临床试验,杂志文章
doi:10.1159/000494207
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Numerous studies have suggested a possible role for acute kidney injury (AKI) biomarkers in predicting renal recovery both before and after renal replacement therapy (RRT). However, definitions for recovery and whether to include patients dying but free of RRT may influence results. OBJECTIVES:To validate p...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000500423
更新日期:2019-01-01 00:00:00
abstract::The principles and use of plasmapheresis are often little understood by intensivists. We propose to review the principles, the main indications, and the methods of using this technique. ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000510983
更新日期:2020-10-22 00:00:00
abstract::Elimination of uremic solutes with molecular weights up to 60 kD, without significant loss of albumin is an important therapeutic goal to optimize outcomes in chronic hemodialysis patients. To characterize a newly developed polysulfone dialyzer (APS-650) a comparative analysis was performed with a highly advanced poly...
journal_title:Blood purification
pub_type: 杂志文章
doi:10.1159/000063099
更新日期:2002-01-01 00:00:00
abstract::Uremic patients suffer from a secondary form of complex dyslipidemia consisting of quantitative and qualitative abnormalities in serum lipoproteins resulting in altered lipoprotein composition and metabolism. The most prominent are an increase in serum triglyceride levels (due to elevated very-low-density lipoprotein ...
journal_title:Blood purification
pub_type: 杂志文章,评审
doi:10.1159/000063557
更新日期:2002-01-01 00:00:00