Calcimimetics versus vitamin D: what are their relative roles?

Abstract:

:A strict control of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) is indicated to avoid serious complications linked to osteitis fibrosa and other parathyroid-hormone (PTH)-related bodily disturbances. However, such a control is often achieved only at the price of unacceptably high plasma calcium and phosphorus levels and the risk of soft tissue calcification, even when using the novel, so-called 'non-hypercalcemic' vitamin D analogs. The advent of a new class of drugs, the calcimimetics, should allow a more adequate control of the disturbed calcium-phosphorus metabolism in CKD patients. In my opinion, the calcimimetics will not replace currently used medications but will be a valuable supplement to presently available treatment options for this major complication in patients with renal failure.

journal_name

Blood Purif

journal_title

Blood purification

authors

Drüeke TB

doi

10.1159/000074922

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

38-43

issue

1

eissn

0253-5068

issn

1421-9735

pii

74922

journal_volume

22

pub_type

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