Abstract:
:Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment of macrophages, activation of chemotactic cytokines, upregulation of matrix remodeling genes, production of free radicals leading to oxidative stress, and ultimately cellular apoptosis. Recent studies have indicated that TNF-α may be a potential target for the development of novel medical therapies, but additional experimental data is needed to clarify the intricacies of TNF-α activation and its critical downstream targets in cerebral aneurysms. This review provides an update on the mechanisms underlying TNF-α-induced molecular modulation in cerebral aneurysms.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Starke RM,Raper DM,Ding D,Chalouhi N,Owens GK,Hasan DM,Medel R,Dumont ASdoi
10.1007/s12975-013-0287-9subject
Has Abstractpub_date
2014-04-01 00:00:00pages
269-77issue
2eissn
1868-4483issn
1868-601Xjournal_volume
5pub_type
杂志文章,评审abstract::Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0401-2
更新日期:2015-08-01 00:00:00
abstract::Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0647-6
更新日期:2018-07-12 00:00:00
abstract::Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00796-y
更新日期:2020-10-01 00:00:00
abstract::Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-015-0410-1
更新日期:2015-08-01 00:00:00
abstract::Quantitative susceptibility mapping (QSM) has been recently introduced as a novel MRI post-processing technique of gradient recalled echo (GRE) data. QSM is useful in depicting both brain anatomy and for detecting abnormalities. Its utility in the context of ischemic stroke has, however, not been extensively character...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0591-x
更新日期:2018-08-01 00:00:00
abstract::Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expect...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0142-9
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0083-3
更新日期:2011-09-01 00:00:00
abstract::The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. There is hypercoagulability associated with COVID-19 that is likely a "sepsis-induced coagulopathy" and may predispose to stroke. The SARS-CoV-2 virus binds to angiotensin-converting enzyme 2 (ACE2) present on brain endo...
journal_title:Translational stroke research
pub_type: 信件
doi:10.1007/s12975-020-00818-9
更新日期:2020-06-01 00:00:00
abstract::Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0623-1
更新日期:2019-02-01 00:00:00
abstract::The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0214-5
更新日期:2013-04-01 00:00:00
abstract::Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00738-3
更新日期:2020-06-01 00:00:00
abstract::Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0545-3
更新日期:2017-12-01 00:00:00
abstract::Intraventricular hemorrhage (IVH), which afflicts thousands of people of all ages every year, frequently results in the development of communicating hydrocephalus. Classically, IVH-induced hydrocephalus has been attributed to reduced resorption of cerebrospinal fluid (CSF) due to dysfunction of arachnoid granulations,...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0070-8
更新日期:2011-06-01 00:00:00
abstract::Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title:Translational stroke research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12975-018-0620-4
更新日期:2018-12-01 00:00:00
abstract::Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0124-y
更新日期:2012-03-01 00:00:00
abstract::Positron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical characteristics of PET tracers may help uncover the pathophysiological consequences of cardiac arrest (CA) and ischemic stroke, which include cerebral ischemia and reperfusio...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-019-00765-0
更新日期:2020-08-01 00:00:00
abstract::Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-014-0323-4
更新日期:2014-04-01 00:00:00
abstract::Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12975-017-0553-3
更新日期:2017-12-01 00:00:00
abstract::Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death of neurons. Injury-mediated inc...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0297-7
更新日期:2014-02-01 00:00:00
abstract::This review focuses on assessment of behavioral outcomes following traumatic brain injury in juvenile animal models. In the 15 years since the first publication in this field, the majority of studies have used rats roughly equivalent to human toddlers in terms of brain development. Few studies have tested ages closer ...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0132-y
更新日期:2011-12-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0392-z
更新日期:2015-06-01 00:00:00
abstract::Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0605-8
更新日期:2018-10-01 00:00:00
abstract::The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0207-4
更新日期:2012-12-01 00:00:00
abstract::Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00875-0
更新日期:2020-11-27 00:00:00
abstract::Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0319-5
更新日期:2014-02-01 00:00:00
abstract::There was an error in Fig. 2d. The correct Fig. 2d is shown below. ...
journal_title:Translational stroke research
pub_type: 已发布勘误
doi:10.1007/s12975-020-00871-4
更新日期:2020-10-22 00:00:00
abstract::An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0554-2
更新日期:2017-07-17 00:00:00
abstract::This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12975-019-0686-7
更新日期:2019-12-01 00:00:00
abstract::Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00757-0
更新日期:2020-08-01 00:00:00
abstract::Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-013-0277-y
更新日期:2013-12-01 00:00:00