Abstract：
:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for the failed translational results. The present article proposes a standardized definition for DCI in experimental mouse models, which can be used as outcome measure in future animal studies. We used a consensus-building approach to propose a definition for "experimental secondary ischemia" (ESI) in experimental mouse subarachnoid hemorrhage that can be used as an outcome measure in preclinical studies. We propose that the outcome measure should be as follows: occurrence of focal neurological impairment or a general neurological impairment compared with a control group and that neurological impairment should occur secondarily following subarachnoid hemorrhage (SAH) induction compared with an initial assessment following SAH induction. ESI should not be used if the condition can be explained by general anesthesia or if other means of assessments sufficiently explain function impairment. If neurological impairment cannot reliably be evaluated, due to scientific setup. Verification of a significant secondary impairment of the cerebral perfusion compared with a control group is mandatory. This requires longitudinal examination in the same animal. The primary aim is that ESI should be distinguished from intervention-related ischemia or neurological deficits, in order establish a uniform definition for experimental SAH in mice that is in alignment with outcome measures in human studies.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
van Lieshout JH,Marbacher S,Muhammad S,Boogaarts HD,Bartels RHMA,Dibué M,Steiger HJ,Hänggi D,Kamp MAdoi
10.1007/s12975-020-00796-ysubject
Has Abstractpub_date
2020-10-01 00:00:00pages
1165-1170issue
5eissn
1868-4483issn
1868-601Xpii
10.1007/s12975-020-00796-yjournal_volume
11pub_type
杂志文章abstract：:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0622-2
更新日期：2019-02-01 00:00:00
abstract：:Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0605-8
更新日期：2018-10-01 00:00:00
abstract：:Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-018-0654-7
更新日期：2019-06-01 00:00:00
abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00749-0
更新日期：2020-08-01 00:00:00
abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0565-z
更新日期：2018-04-01 00:00:00
abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0545-3
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0083-3
更新日期：2011-09-01 00:00:00
abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-014-0323-4
更新日期：2014-04-01 00:00:00
abstract：:Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0577-8
更新日期：2018-06-01 00:00:00
abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00838-5
更新日期：2020-08-07 00:00:00
abstract：:Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-013-0265-2
更新日期：2013-10-01 00:00:00
abstract：:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-015-0401-2
更新日期：2015-08-01 00:00:00
abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00711-0
更新日期：2020-04-01 00:00:00
abstract：:Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0287-9
更新日期：2014-04-01 00:00:00
abstract：:Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-015-0410-1
更新日期：2015-08-01 00:00:00
abstract：:Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-018-0623-1
更新日期：2019-02-01 00:00:00
abstract：:Acute ischemic stroke (AIS) often results in degeneration of the blood-brain barrier (BBB), which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. Imatinib is an agent that may be able to protect the BBB and reduce the risk of the harmful consequences of BBB degeneration. We sought to mea...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-014-0358-6
更新日期：2015-02-01 00:00:00
abstract：:Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular disease...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0585-8
更新日期：2018-06-01 00:00:00
abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-013-0277-y
更新日期：2013-12-01 00:00:00
abstract：:Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00757-0
更新日期：2020-08-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) has dramatically changed our ability to diagnose and treat stroke as well as follow its evolution and response to treatment. Early stroke and ischemia can be visualized using diffusion-weighted imaging that utilizes water diffusion within tissues as a reporter for evolving neuropatholo...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0139-4
更新日期：2012-03-01 00:00:00
abstract：:The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title：Translational stroke research
pub_type： 杂志文章,评审
doi：10.1007/s12975-012-0237-y
更新日期：2013-08-01 00:00:00
abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title：Translational stroke research
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12975-018-0620-4
更新日期：2018-12-01 00:00:00
abstract：:Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-012-0188-3
更新日期：2012-07-01 00:00:00
abstract：:Cerebral blood flow (CBF) is the key factor for identifying progressive hypoperfusion that is indicative of numerous pathological conditions. CBF measurement is beneficial for the management of cerebrovascular disease, head injury, and intracranial neoplasms. Of the various imaging modalities developed to assess CBF, ...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0064-y
更新日期：2011-06-01 00:00:00
abstract：:Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain lesion formation, growth, and maturation. We used genetic methods to e...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-019-00725-8
更新日期：2020-06-01 00:00:00
abstract：:Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-011-0126-9
更新日期：2011-12-01 00:00:00
abstract：:Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) woul...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-017-0604-9
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-010-0022-8
更新日期：2010-06-01 00:00:00
abstract：:Monocytes recruitment from the blood to inflamed tissues following ischemic stroke is an important immune response to wound healing and tissue repair. Mouse monocytes can be endogenously divided into two distinct populations: pro-inflammatory or classical monocytes that express CCR2highCX3CR1low and circulate in blood...
journal_title：Translational stroke research
pub_type： 杂志文章
doi：10.1007/s12975-020-00878-x
更新日期：2021-01-06 00:00:00
