Tissue plasminogen activator induced delayed edema in experimental porcine intracranial hemorrhage: reduction with plasminogen activator inhibitor-1 administration.

abstract：:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evi...

journal_title：Translational stroke research

authors： Bell JD,Cho JE,Giffard RG

更新日期：2017-12-01 00:00:00

abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...

journal_title：Translational stroke research

authors： Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SC

更新日期：2018-07-12 00:00:00

abstract：:Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...

journal_title：Translational stroke research

authors： Learoyd AE,Woodhouse L,Shaw L,Sprigg N,Bereczki D,Berge E,Caso V,Christensen H,Collins R,Czlonkowska A,El Etribi A,Farr TD,Gommans J,Laska AC,Ntaios G,Ozturk S,Pocock SJ,Prasad K,Wardlaw JM,Fone KC,Bath PM,Truem

更新日期：2017-12-01 00:00:00

abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...

journal_title：Translational stroke research

authors： Brown CM,Bushnell CD,Samsa GP,Goldstein LB,Colton CA

更新日期：2015-12-01 00:00:00

abstract：:Rodent animal models of stroke are widely used with brain ischemia inducible by various occlusion methods. Permanent or transient occlusion of the distal portion of the middle cerebral artery (MCAO) offers a reproducible model with low mortality rates, and it is the most likely model of choice for mid- and long-term s...

journal_title：Translational stroke research

authors： Rosell A,Agin V,Rahman M,Morancho A,Ali C,Koistinaho J,Wang X,Vivien D,Schwaninger M,Montaner J

更新日期：2013-06-01 00:00:00

abstract：:Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....

journal_title：Translational stroke research

authors： Liu Y,Eaton ED,Wills TE,McCann SK,Antonic A,Howells DW

更新日期：2018-12-01 00:00:00

abstract：:Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...

journal_title：Translational stroke research

authors： Rincon F,Mayer SA

更新日期：2012-07-01 00:00:00

abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...

journal_title：Translational stroke research

authors： Zanaty M,Chalouhi N,Tjoumakaris SI,Rosenwasser RH,Jabbour PM

更新日期：2014-04-01 00:00:00

abstract：:Inflammation is a critical process behind cerebral aneurysm formation and rupture. Tumor necrosis factor alpha (TNF-α) is a key immune modulator that has been implicated in cerebral aneurysm pathophysiology. This may occur through TNF-α-mediated endothelial injury, smooth muscle cell phenotypic modulation, recruitment...

journal_title：Translational stroke research

authors： Starke RM,Raper DM,Ding D,Chalouhi N,Owens GK,Hasan DM,Medel R,Dumont AS

更新日期：2014-04-01 00:00:00

abstract：:Systemic docosahexaenoic acid (DHA) has been explored as a clinically feasible protectant in stroke models. However, the mechanism for DHA-afforded neuroprotection remains elusive. Transient middle cerebral artery occlusion (tMCAO) was induced for 1 h. DHA (i.p., 10 mg/kg) was administered immediately after reperfusio...

journal_title：Translational stroke research

authors： Cai W,Liu S,Hu M,Sun X,Qiu W,Zheng S,Hu X,Lu Z

更新日期：2018-12-01 00:00:00

abstract：:Neurogenesis is essential for a good post-stroke outcome. Exogenous stem cells are currently being tested to promote neurogenesis after stroke. Elsewhere, we demonstrated that treatment with the PPARγ agonist pioglitazone (PGZ) before cerebral ischemia induction reduced brain damage and activated survival-related gene...

journal_title：Translational stroke research

authors： Kinouchi T,Kitazato KT,Shimada K,Yagi K,Tada Y,Matsushita N,Kurashiki Y,Satomi J,Sata M,Nagahiro S

更新日期：2018-06-01 00:00:00

abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...

journal_title：Translational stroke research

authors： Schrag M,Mac Grory B,Nackenoff A,Eaton J,Mistry E,Kirshner H,Yaghi S,Ellis CR

更新日期：2020-08-07 00:00:00

abstract：:Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increa...

journal_title：Translational stroke research

authors： Tso MK,Macdonald RL

更新日期：2014-04-01 00:00:00

abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...

journal_title：Translational stroke research

authors： Herson PS,Palmateer J,Hurn PD

更新日期：2013-08-01 00:00:00

abstract：:This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...

journal_title：Translational stroke research

authors： Chu H,Huang C,Dong J,Yang X,Xiang J,Dong Q,Tang Y

更新日期：2019-12-01 00:00:00

abstract：:Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution...

journal_title：Translational stroke research

authors： O'Connell GC,Treadway MB,Tennant CS,Lucke-Wold N,Chantler PD,Barr TL

更新日期：2019-02-01 00:00:00

abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...

journal_title：Translational stroke research

authors： Selim M

更新日期：2010-03-01 00:00:00

abstract：:Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...

journal_title：Translational stroke research

authors： Adil SM,Liu B,Charalambous LT,Kiyani M,Gramer R,Swisher CB,Verbick LZ,McCabe A,Parente BA,Pagadala P,Lad SP

更新日期：2019-12-01 00:00:00

abstract：:Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...

journal_title：Translational stroke research

authors： Yigitkanli K,Zheng Y,Pekcec A,Lo EH,van Leyen K

更新日期：2017-04-01 00:00:00

abstract：:Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expect...

journal_title：Translational stroke research

authors： An H,Sen S,Chen Y,Powers WJ,Lin W

更新日期：2012-06-01 00:00:00

abstract：:Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...

journal_title：Translational stroke research

authors： Shukla V,Fuchs P,Liu A,Cohan CH,Dong C,Wright CB,Perez-Pinzon MA,Dave KR

更新日期：2019-02-01 00:00:00

abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...

journal_title：Translational stroke research

authors： McBride DW,Zhang JH

更新日期：2017-07-17 00:00:00

abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...

journal_title：Translational stroke research

authors： Loris ZB,Hynton JR,Pieper AA,Dietrich WD

更新日期：2018-04-01 00:00:00

abstract：:Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...

journal_title：Translational stroke research

authors： O'Bryant Z,Vann KT,Xiong ZG

更新日期：2014-02-01 00:00:00

abstract：:Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...

journal_title：Translational stroke research

authors： Xiao Y,Rivaz H,Kasuya H,Yokosako S,Mindru C,Teitelbaum J,Sirhan D,Sinclair D,Angle M,Lo BWY

更新日期：2018-10-01 00:00:00

abstract：:Despite being a conveniently portable technology for stroke assessment, Transcranial Doppler ultrasound (TCD) remains widely underutilized due to complex training requirements necessary to reliably obtain and interpret cerebral blood flow velocity (CBFV) waveforms. The validation of objective TCD metrics for large ves...

journal_title：Translational stroke research

authors： Thorpe SG,Thibeault CM,Wilk SJ,O'Brien M,Canac N,Ranjbaran M,Devlin C,Devlin T,Hamilton RB

更新日期：2019-10-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage comprises of an early phase after the bleeding and a late phase of delayed consequences of the bleeding. The development of delayed injury mechanisms, like the reduction of cerebral blood flow (CBF) due to cerebral vasospasm (CVS), seems mainly to depend on the amount and the duratio...

journal_title：Translational stroke research

authors： Güresir E,Schuss P,Borger V,Vatter H

更新日期：2015-06-01 00:00:00

abstract：:Pulmonary complications associated with persistent respiratory muscle weakness, paralysis, and spasticity are among the most important problems faced by patients with spinal cord injury when lack of muscle strength and disorganization of reciprocal respiratory muscle control lead to breathing insufficiency. This revie...

journal_title：Translational stroke research

authors： Terson de Paleville DG,McKay WB,Folz RJ,Ovechkin AV

更新日期：2011-12-01 00:00:00

abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...

journal_title：Translational stroke research

authors： Alawieh A,Tomlinson S,Adkins D,Kautz S,Feng W

更新日期：2017-12-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...

journal_title：Translational stroke research

authors： Doycheva D,Shih G,Chen H,Applegate R,Zhang JH,Tang J

更新日期：2013-04-01 00:00:00