Abstract:
:Preconditioning is a paradigm in which sublethal stress-prior to a more injurious insult-induces protection against injury. In the central nervous system (CNS), preconditioning against ischemic stroke is induced by short durations of ischemia, brief seizures, exposure to anesthetics, and other stresses. Increasing evidence supports the contribution of microRNAs (miRNAs) to the pathogenesis of cerebral ischemia and ischemic tolerance induced by preconditioning. Studies investigating miRNA changes induced by preconditioning have to date identified 562 miRNAs that change expression levels after preconditioning, and 15% of these changes were reproduced in at least one additional study. Of miRNAs assessed as changed by preconditioning in more than one study, about 40% changed in the same direction in more than one study. Most of the studies to assess the role of specific miRNAs in the neuroprotective mechanism of preconditioning were performed in vitro, with fewer studies manipulating individual miRNAs in vivo. Thus, while many miRNAs change in response to preconditioning stimuli, the mechanisms underlying their effects are not well understood. The data does suggest that miRNAs may play significant roles in preconditioning-induced neuroprotection. This review focuses on the current state of knowledge of the possible role of miRNAs in preconditioning-induced cerebral protection.
journal_name
Transl Stroke Resjournal_title
Translational stroke researchauthors
Bell JD,Cho JE,Giffard RGdoi
10.1007/s12975-017-0547-1subject
Has Abstractpub_date
2017-12-01 00:00:00pages
585-596issue
6eissn
1868-4483issn
1868-601Xpii
10.1007/s12975-017-0547-1journal_volume
8pub_type
杂志文章,评审abstract::This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12975-019-0686-7
更新日期:2019-12-01 00:00:00
abstract::Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0185-6
更新日期:2012-07-01 00:00:00
abstract::The long-term effects of multiple sport-related concussions are currently at the center of debate in the popular press and scientific community. The question, "How many concussions are too many," is frequently asked in the competitive sport environment by parents, athletes, and coaches. While research suggests that a ...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0237-y
更新日期:2013-08-01 00:00:00
abstract::Traumatic brain injury (TBI) affects all age groups in a population and is an injury generating scientific interest not only as an acute event, but also as a complex brain disease with several underlying neurobehavioral and neuropathological characteristics. We review early and long-term alterations after juvenile and...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0126-9
更新日期:2011-12-01 00:00:00
abstract::Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0403-0
更新日期:2015-08-01 00:00:00
abstract::Increasing endogenous ciliary neurotrophic factor (CNTF) expression with a pharmacological agent might be beneficial after stroke as CNTF both promotes neurogenesis and, separately, is neuroprotective. P2X7 purinergic receptor inhibition is neuroprotective in rats and increases CNTF release in rat CMT1A Schwann cells....
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-013-0265-2
更新日期:2013-10-01 00:00:00
abstract::Intracerebral hemorrhage is by far the most destructive form of stroke. Apart from the management in a specialized stroke or neurological intensive care unit (NICU), no specific therapies have been shown to consistently improve outcomes after ICH. Current guidelines endorse early aggressive optimization of physiologic...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0175-8
更新日期:2012-07-01 00:00:00
abstract::Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-017-0551-5
更新日期:2017-12-01 00:00:00
abstract::In a porcine ischemic stroke model, we sought to compare the acute predicted infarct core volume (PIV) defined by CT perfusion (CTP)-hemodynamic parameters and MR-diffusion-weighted imaging (MR-DWI)/apparent diffusion coefficient (ADC), with the true infarct core volume (TIV) as defined by histology. Ten Duroc-cross p...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0394-x
更新日期:2015-06-01 00:00:00
abstract::Early infection after stroke is associated with a poor outcome. We aimed to determine whether delayed infections (up to 76 days post-stroke) are associated with poor outcome at 90 days. Data came from the international Efficacy of Nitric Oxide Stroke (ENOS, ISRCTN99414122) trial. Post hoc data on infections were obtai...
journal_title:Translational stroke research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s12975-017-0553-3
更新日期:2017-12-01 00:00:00
abstract::Diabetes significantly increases the risk of stroke and post-stroke mortality. Recurrent hypoglycemia (RH) is common among diabetes patients owing to glucose-lowering therapies. Earlier, we showed that RH in a rat model of insulin-dependent diabetes exacerbates cerebral ischemic damage. Impaired mitochondrial function...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0622-2
更新日期:2019-02-01 00:00:00
abstract::Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of th...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0605-8
更新日期:2018-10-01 00:00:00
abstract::Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-018-0654-7
更新日期:2019-06-01 00:00:00
abstract::The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-012-0207-4
更新日期:2012-12-01 00:00:00
abstract::In the original publication of the article, there was a switched order of author names. ...
journal_title:Translational stroke research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12975-018-0618-y
更新日期:2018-12-01 00:00:00
abstract::Pulmonary complications associated with persistent respiratory muscle weakness, paralysis, and spasticity are among the most important problems faced by patients with spinal cord injury when lack of muscle strength and disorganization of reciprocal respiratory muscle control lead to breathing insufficiency. This revie...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0114-0
更新日期:2011-12-01 00:00:00
abstract::Noninvasive magnetic resonance (MR) methods have been explored to provide quantitative measurements of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and oxygen metabolic index (OMI = CBF × OEF). In this study, we sought to evaluate whether MR measured OEF, CBF, and OMI can consistently detect the expect...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-011-0142-9
更新日期:2012-06-01 00:00:00
abstract::Although used extensively in stroke research, there is limited knowledge of how 2, 3, 5-triphenyltetrazolium chloride (TTC)-treated rat brain sections are altered and if they can be used for immunohistochemical quantification after staining with TTC. In the present study, we hypothesized that TTC treatment (TTC+) woul...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-017-0604-9
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-010-0022-8
更新日期:2010-06-01 00:00:00
abstract::Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers....
journal_title:Translational stroke research
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12975-018-0620-4
更新日期:2018-12-01 00:00:00
abstract::Activation and repression of gene expression are key features of ischemic tolerance. Converging lines of inquiry from several groups suggests that epigenetic proteins may transduce sublethal stresses, including bioenergetic or oxidative stress into durable (2-3 days) changes in gene expression that mediate ischemic to...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-012-0235-0
更新日期:2013-02-01 00:00:00
abstract::Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion occurs in a large subset of patients and is a predictor of poor outcomes. Since hematoma growth provides a potential opportunity for therapeutic...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-015-0410-1
更新日期:2015-08-01 00:00:00
abstract::Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00711-0
更新日期:2020-04-01 00:00:00
abstract::Positron emission tomography (PET) is widely used in clinical and animal studies, along with the development of diverse tracers. The biochemical characteristics of PET tracers may help uncover the pathophysiological consequences of cardiac arrest (CA) and ischemic stroke, which include cerebral ischemia and reperfusio...
journal_title:Translational stroke research
pub_type: 杂志文章,评审
doi:10.1007/s12975-019-00765-0
更新日期:2020-08-01 00:00:00
abstract::Poor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patie...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-020-00856-3
更新日期:2020-09-28 00:00:00
abstract::Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it is an appropriate treatment target. We investigated complement ex...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00757-0
更新日期:2020-08-01 00:00:00
abstract::Global ischemia following cardiac arrest is characterized by high mortality and significant neurological deficits in long-term survivors. Its mechanisms of neuronal cell death have only partially been elucidated. 12/15-lipoxygenase (12/15-LOX) is a major contributor to delayed neuronal cell death and vascular injury i...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-016-0509-z
更新日期:2017-04-01 00:00:00
abstract::Systemic docosahexaenoic acid (DHA) has been explored as a clinically feasible protectant in stroke models. However, the mechanism for DHA-afforded neuroprotection remains elusive. Transient middle cerebral artery occlusion (tMCAO) was induced for 1 h. DHA (i.p., 10 mg/kg) was administered immediately after reperfusio...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-018-0662-7
更新日期:2018-12-01 00:00:00
abstract::Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-015-0401-2
更新日期:2015-08-01 00:00:00
abstract::Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (HCRU) and health economic burden incurred by the US health syste...
journal_title:Translational stroke research
pub_type: 杂志文章
doi:10.1007/s12975-019-00697-9
更新日期:2019-12-01 00:00:00