Noninvasive Measurements of Cerebral Blood Flow, Oxygen Extraction Fraction, and Oxygen Metabolic Index in Human with Inhalation of Air and Carbogen using Magnetic Resonance Imaging.

abstract：:Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for str...

journal_title：Translational stroke research

authors： Fisher M,Vasilevko V,Cribbs DH

更新日期：2012-07-01 00:00:00

abstract：:Inconsistency in outcome parameters for delayed cerebral ischemia (DCI) makes it difficult to compare results between mouse studies, in the same way inconsistency in outcome parameters in human studies has for long obstructed adequate comparison. The absence of an established definition may in part be responsible for ...

journal_title：Translational stroke research

authors： van Lieshout JH,Marbacher S,Muhammad S,Boogaarts HD,Bartels RHMA,Dibué M,Steiger HJ,Hänggi D,Kamp MA

更新日期：2020-10-01 00:00:00

abstract：:The iron chelator, deferoxamine mesylate (DFO), has shown neuroprotective effects, mediated via suppression of iron-induced hydroxyl radical formation, in various animal models of ischemic and hemorrhagic stroke. Therefore, the objective of this study was to investigate whether DFO can exert similar actions in stroke ...

journal_title：Translational stroke research

authors： Selim M

更新日期：2010-03-01 00:00:00

abstract：:The presence of active developmental angiogenesis and vascular outgrowth in the postnatal brain may differentially affect vascular responses to stroke in newborns and adults, but very little is known about the dynamics of vascular injury and re-growth after stroke during the neonatal period. In this study we used a cl...

journal_title：Translational stroke research

authors： Fernández-López D,Faustino J,Derugin N,Vexler ZS

更新日期：2013-04-01 00:00:00

abstract：:Management of intracranial aneurysms remains controversial. For unruptured aneurysms, many factors should be taken into account before deciding the type of treatment and whether to treat or not. Ruptured aneurysms on the other hand are almost always treated. Still, the question remains what are the indicators that one...

journal_title：Translational stroke research

authors： Zanaty M,Chalouhi N,Tjoumakaris SI,Rosenwasser RH,Jabbour PM

更新日期：2014-04-01 00:00:00

abstract：:Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infectious outcome is unclear. To examine the effect of infarct size on post-stroke infection, we utilised the intraluminal middle-cerebral artery occlusion (MCAO) mouse model of ischemic stroke a...

journal_title：Translational stroke research

authors： Shim R,Wen SW,Wanrooy BJ,Rank M,Thirugnanachandran T,Ho L,Sepehrizadeh T,de Veer M,Srikanth VK,Ma H,Phan TG,Sobey CG,Wong CHY

更新日期：2020-06-01 00:00:00

abstract：:An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% o...

journal_title：Translational stroke research

authors： McBride DW,Zhang JH

更新日期：2017-07-17 00:00:00

abstract：OBJECTIVE:To elucidate the role of magnesium sulfate in patients with subarachnoid hemorrhagic (SAH) brain injury METHOD:Studies for the meta-analysis were identified from PubMed (1966 to 2009), Embase (1980 to 2009), and two Chinese journals (1989 to 2009). Paper selection was based on randomized controlled trials co...

journal_title：Translational stroke research

authors： Huang B,Khatibi NH,Tong L,Yan P,Xie P,Zhang JH

更新日期：2010-06-01 00:00:00

abstract：:Circulating levels of the pro-inflammatory cytokine C-C motif chemokine 11 (CCL11, also known as eotaxin-1) are increased in several animal models of neuroinflammation, including traumatic brain injury and Alzheimer's disease. Increased levels of CCL11 have also been linked to decreased neurogenesis in mice. We hypoth...

journal_title：Translational stroke research

authors： Roy-O'Reilly M,Ritzel RM,Conway SE,Staff I,Fortunato G,McCullough LD

更新日期：2017-12-01 00:00:00

abstract：:Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion...

journal_title：Translational stroke research

authors： Loris ZB,Hynton JR,Pieper AA,Dietrich WD

更新日期：2018-04-01 00:00:00

abstract：:Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immedia...

journal_title：Translational stroke research

authors： Keric N,Maier GS,Samadani U,Kallenberg K,Dechent P,Brueck W,Heuer J,Rohde V

更新日期：2012-07-01 00:00:00

abstract：:Clinical studies on subarachnoid hemorrhage (SAH) have shown discrepancies between large vessel vasospasm, cerebral perfusion, and clinical outcome. We set out to analyze the contribution of large vessel vasospasm to impaired cerebral perfusion and neurological impairment in a murine model of SAH. SAH was induced in C...

journal_title：Translational stroke research

authors： Neulen A,Meyer S,Kramer A,Pantel T,Kosterhon M,Kunzelmann S,Goetz H,Thal SC

更新日期：2018-07-12 00:00:00

abstract：:Silent information regulator 1 (SIRT1) is a NAD+-dependent histone deacetylase that represses gene expression and plays a role in longevity. SIRT1 responds to diverse stress conditions and regulates metabolism in nutrient deficiency conditions; therefore, it is involved in adaptive pathways to better fulfill tissue ne...

journal_title：Translational stroke research

authors： Petegnief V,Planas AM

更新日期：2013-12-01 00:00:00

abstract：:Pathophysiological findings of early brain injury in humans have not permitted conclusive determinations. We explored the essence of this phenomenon by taking intraoperative cortical specimens of Hunt-Kosnik grades IV~V (poor-grade) subarachnoid hemorrhages (SAH). From 2013 to 2017, we treated 39 consecutive poor-grad...

journal_title：Translational stroke research

authors： Shimamura N,Fumoto T,Naraoka M,Katagai T,Fujiwara N,Katayama K,Kinoshita S,Yanagiya K,Sasaki T,Kurose A,Ohkuma H

更新日期：2020-11-27 00:00:00

abstract：:The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 ...

journal_title：Translational stroke research

authors： Brown CM,Bushnell CD,Samsa GP,Goldstein LB,Colton CA

更新日期：2015-12-01 00:00:00

abstract：:This study aimed to investigate whether serum lactate dehydrogenase (LDH) levels predicted hematoma expansion and poor outcomes in intracerebral hemorrhage (ICH) patients. The differentially expressed proteins between patients with and without hematoma expansion were screened using proteomic analysis. Then the critica...

journal_title：Translational stroke research

authors： Chu H,Huang C,Dong J,Yang X,Xiang J,Dong Q,Tang Y

更新日期：2019-12-01 00:00:00

abstract：:In clinical trials, assessing efficacy is based on validated scales, and the primary endpoint is usually based on a single scale. The aim of the review is to revisit the concepts and methods to design and analyze studies focused on restoration, recovery and or compensation. These studies are becoming more frequent wit...

journal_title：Translational stroke research

authors： Hommel M,Detante O,Favre I,Touzé E,Jaillard A

更新日期：2016-10-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is a devastating condition resulting in neuronal cell death and often culminates in neurological deficits. Granulocyte-colony stimulating factor (G-CSF) has been shown to have neuroprotective activity via inhibition of apoptosis and inflammation in various stroke models. Stem cell factor...

journal_title：Translational stroke research

authors： Doycheva D,Shih G,Chen H,Applegate R,Zhang JH,Tang J

更新日期：2013-04-01 00:00:00

abstract：:Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administ...

journal_title：Translational stroke research

authors： O'Bryant Z,Vann KT,Xiong ZG

更新日期：2014-02-01 00:00:00

abstract：:Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Pati...

journal_title：Translational stroke research

authors： Waje-Andreassen U,Naess H,Thomassen L,Maroy TH,Mazengia KY,Eide GE,Vedeler CA

更新日期：2015-08-01 00:00:00

abstract：:The most deadly form of stroke, intracerebral hemorrhage (ICH) continues to puzzle researchers and produce substantial decrements in the quality of patients' lives. Intensive basic research has devised many agents with putative benefit in mitigating the devastating effects of ICH, but these therapies have been largely...

journal_title：Translational stroke research

authors： Ayer A,Hwang BY,Appelboom G,Connolly ES Jr

更新日期：2012-12-01 00:00:00

abstract：:Stroke is a cerebrovascular disorder that affects many people worldwide. Pericytes play an important role in stroke progression and recovery. The sigma-1 receptor (σ-1R) signaling pathway has been suggested as having promising neuroprotective potential in treating stroke; however, whether σ-1R activation regulates per...

journal_title：Translational stroke research

authors： Zhang Y,Zhang X,Wei Q,Leng S,Li C,Han B,Bai Y,Zhang H,Yao H

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Admission hyperglycemia impacts ischemic stroke deleteriously but the relative role of acute hyperglycemia (HG) versus diabetes in the pathogenesis of this poor outcome is not clear. PURPOSE:To determine the effect of acute HG on neurovascular outcomes of stroke under control and diabetic conditions. METHO...

journal_title：Translational stroke research

authors： Elgebaly MM,Ogbi S,Li W,Mezzetti EM,Prakash R,Johnson MH,Bruno A,Fagan SC,Ergul A

更新日期：2011-09-01 00:00:00

abstract：:CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL s...

journal_title：Translational stroke research

authors： Fan L,Zhang CJ,Zhu L,Chen J,Zhang Z,Liu P,Cao X,Meng H,Xu Y

更新日期：2020-08-01 00:00:00

abstract：:Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Ba...

journal_title：Translational stroke research

authors： Sakamoto M,Miyazaki Y,Kitajo K,Yamaguchi A

更新日期：2015-08-01 00:00:00

abstract：:Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggest...

journal_title：Translational stroke research

authors： Alawieh A,Tomlinson S,Adkins D,Kautz S,Feng W

更新日期：2017-12-01 00:00:00

abstract：:Subarachnoid haemorrhage (SAH) is a devastating disease and a major burden on society. Despite this, pharmacological treatment options are limited. Appropriate animal modelling of SAH is essential for the development of neuroprotective drugs, but experimental SAH often fails to produce widespread neuronal loss, as fre...

journal_title：Translational stroke research

authors： Greenhalgh AD,Rothwell NJ,Allan SM

更新日期：2012-03-01 00:00:00

abstract：:Cerebrovascular disease is a leading cause of death-from-disease and of disability worldwide, affecting some 15 million people. The incidence of stroke or "brain attack" is unlikely to recede for a decade at minimum by most predictions, despite large public health initiatives in stroke prevention. It has been well est...

journal_title：Translational stroke research

authors： Herson PS,Palmateer J,Hurn PD

更新日期：2013-08-01 00:00:00

abstract：:Approximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for str...

journal_title：Translational stroke research

authors： Otero-Ortega L,Laso-García F,Gómez-de Frutos M,Fuentes B,Diekhorst L,Díez-Tejedor E,Gutiérrez-Fernández M

更新日期：2019-06-01 00:00:00

abstract：:Anticoagulation increases the risk of intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA), so the management of stroke-risk in patients with both atrial fibrillation (AF) and CAA is controversial. Advances in left atrial appendage closure (LAAC) techniques provide a stroke-risk-reduction ...

journal_title：Translational stroke research

authors： Schrag M,Mac Grory B,Nackenoff A,Eaton J,Mistry E,Kirshner H,Yaghi S,Ellis CR

更新日期：2020-08-07 00:00:00